Explanipedia

Modeling a mesenchymal cell state by bioprinting for the molecular analysis of dormancy in melanoma Open

Sonja Schmidt, Stefan Fischer, Zubeir El Ahmad, Rafael Schmid, Eric Metzger , et al. · 2025

The spleen-liver axis supports obesity-induced systemic and fatty liver inflammation via MDSC and NKT cell enrichment Open

Christina Brummer, Katrin Singer, Kathrin Renner, Christina Bruß, Claus Hellerbrand , et al. · 2025

Sex-Dependent T Cell Dysregulation in Mice with Diet-Induced Obesity Open

Christina Brummer, Katrin Singer, Almut Brand, Christina Bruß, Kathrin Renner , et al. · 2024

Obesity is an emerging public health problem. Chronic low-grade inflammation is considered a major promotor of obesity-induced secondary diseases such as cardiovascular and fatty liver disease, type 2 diabetes mellitus, and several cancer …

Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity Open

Judith Sommer, Hanna Ehnis, Tatjana Seitz, Júlia Schneider, Andreas B. Wild , et al. · 2023

Obesity is characterized by the expansion of the adipose tissue, usually accompanied by inflammation, with a prominent role of macrophages infiltrating the visceral adipose tissue (VAT). This chronic inflammation is a major driver of obesi…

Bone Morphogenetic Protein 13 Has Protumorigenic Effects on Hepatocellular Carcinoma Cells In Vitro Open

Vanessa Kersten, Tatjana Seitz, Judith Sommer, Wolfgang E. Thasler, Anja‐Katrin Bosserhoff , et al. · 2023

Activated hepatic stellate cells (HSCs) play a key role in hepatic fibrosis and, thus, build the “soil” for hepatocarcinogenesis. Furthermore, HSCs are known to promote the progression of hepatocellular carcinoma (HCC), but the molecular m…

Expression of Bone Morphogenetic Protein 14 in Liver Disease and Cancer Open

Judith Sommer, Wolfgang E. Thasler, Anja‐Katrin Bosserhoff, Claus Hellerbrand · 2023

The activation of hepatic stellate cells (HSCs) is the key event of hepatic fibrosis. Furthermore, activated HSCs also play an important role in the progression of hepatocellular cancer (HCC). Bone morphogenetic protein 14 (BMP14) is a mem…

Lipid Accumulation in Host Cells Promotes SARS-CoV-2 Replication Open

Tatjana Seitz, Christian Setz, Pia Rauch, Ulrich S. Schubert, Claus Hellerbrand · 2023

Coronavirus disease-19 (COVID-19) is still affecting the lives of people around the globe and remains a major public health threat. Lipid levels in the host cells have been shown to promote SARS-CoV-2 replication, and since the start of CO…

Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1 Open

Cristina Ortiz, Sabine Klein, Winfried Reul, Fernando Magdaleno, Stefanie Gröschl , et al. · 2023

A Xanthohumol-Rich Hop Extract Diminishes Endotoxin-Induced Activation of TLR4 Signaling in Human Peripheral Blood Mononuclear Cells: A Study in Healthy Women Open

Finn Jung, Raphaela Staltner, Anja Baumann, Katharina Burger, Emina Halilbasic , et al. · 2022

Infections with Gram-negative bacteria are still among the leading causes of infection-related deaths. Several studies suggest that the chalcone xanthohumol (XN) found in hop (Humulus lupulus) possesses anti-inflammatory effects. In a sing…

Role of Fibroblast Growth Factors in the Crosstalk of Hepatic Stellate Cells and Uveal Melanoma Cells in the Liver Metastatic Niche Open

Tatjana Seitz, Nora John, Judith Sommer, Peter Dietrich, Wolfgang E. Thasler , et al. · 2022

Hepatic metastasis is the critical factor determining tumor-associated mortality in different types of cancer. This is particularly true for uveal melanoma (UM), which almost exclusively metastasizes to the liver. Hepatic stellate cells (H…

Oral intake of xanthohumol attenuates lipoteichoic acid-induced inflammatory response in human PBMCs Open

Finn Jung, Raphaela Staltner, Ammar Tahir, Anja Baumann, Katharina Burger , et al. · 2022

Purpose The aim of the study was to determine if xanthohumol, a prenylated chalcone found in Hop ( Humulus lupulus ), has anti-inflammatory effects in healthy humans if applied in low doses achievable through dietary intake. Methods In a p…

Association of polymorphous light eruption with NOD‐2 and TLR‐5 gene polymorphisms Open

Bernadett Kurz, Stephanie Arndt, Petra Unger, Irina Ivanova, Mark Berneburg , et al. · 2022

Background Polymorphous light eruption (PLE) is a common, immunologically mediated, photosensitive skin disease. After ultraviolet‐B (UV‐B) irradiation, patients with PLE show reduced Langerhans cell (LC) depletion in the epidermis, which …

Bone morphogenetic protein 13 in hepatic stellate cells and hepatic fibrosis Open

Vanessa Peschl, Tatjana Seitz, Judith Sommer, Wolfgang E. Thasler, Anja‐Katrin Bosserhoff , et al. · 2022

Hepatic fibrosis can be considered as a deregulated wound healing process in response to chronic liver injury. Bone morphogenetic protein 13 (BMP13) has been described to promote bone and tendon repair. In this study, we aimed to analyze t…

Dual Inhibition of mTORC1/2 Reduces Migration of Cholangiocarcinoma Cells by Regulation of Matrixmetalloproteinases Open

Katharina Joechle, Huda Jumaa, Kerstin Thriene, Claus Hellerbrand, Birte Kulemann , et al. · 2022

Cholangiocarcinoma (CCA) is a rare but highly aggressive tumor entity for which systemic therapies only showed limited efficacy so far. As OSI-027—a dual kinase inhibitor targeting both mTOR complexes, mTORC1 and mTORC2 - showed improved a…

Role of mammalian target of rapamycin complex 2 in primary and secondary liver cancer Open

Katharina Joechle, Jessica Guenzle, Claus Hellerbrand, Pavel Strnad, Thorsten Cramer , et al. · 2021

The mammalian target of rapamycin (mTOR) acts in two structurally and functionally distinct protein complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). Upon deregulation, activated mTOR signaling is associated with multiple pro…

Intercellular crosstalk regulating ARRB2/RARRES1 is involved in transition from fibrosis to cancer Open

Robert Schierwagen, Peter Dietrich, Judith Heinzen, Sabine Klein, Frank Erhard Uschner , et al. · 2021

Progressive fibrogenesis in chronic liver injury is often associated with cancer development. Beta-arrestin-2 (ARRB2) is a regulator of the profibrotic Angiotensin II type 1 receptor (AGTR1). The role of ARRB2 in liver fibrosis and in the …

Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11 Open

Anne Gaza, Valerie Fritz, Lara Malek, Laura Wormser, Nora Treiber , et al. · 2021

Combined De-Repression of Chemoresistance Associated Mitogen-Activated Protein Kinase 14 and Activating Transcription Factor 2 by Loss of microRNA-622 in Hepatocellular Carcinoma Open

Valerie Fritz, Lara Malek, Anne Gaza, Laura Wormser, Majken Appel , et al. · 2021

Chemoresistance is a major hallmark driving the progression and poor prognosis of hepatocellular carcinoma (HCC). Limited chemoresponse of HCC was demonstrated to be mediated by mitogen-activated protein kinase 14 (MAPK14) and activating t…

Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye Open

Zheng Li, Zhenxun Wang, Mei Lee, Matthias Zenkel, Kai Lay Esther Peh , et al. · 2021

In this whole-exome sequencing case-control study, presence of exfoliation syndrome was significantly associated with carriage of functionally deficient CYP39A1 sequence variants. Further research is needed to understand the clinical impli…

Xanthohumol, a Prenylated Chalcone Derived from Hops, Inhibits Growth and Metastasis of Melanoma Cells Open

Tatjana Seitz, Christina Hackl, K Freese, Peter Dietrich, A Mahli , et al. · 2021

Melanoma is one of the most aggressive and lethal cancers worldwide. Despite recent progress in melanoma therapy, the prognosis for metastasized melanoma continues to be poor. Xanthohumol (XN), a prenylated chalcone derived from hop cones,…

Neprilysin-Dependent Neuropeptide Y Cleavage in the Liver Promotes Fibrosis by Blocking Npy-Receptor 1 Open

Cristina Ortiz, Sabine Klein, Winfried Reul, Fernando Magdaleno, Stefanie Gröschl , et al. · 2021

Pharmacological Inhibition of mTORC2 Reduces Migration and Metastasis in Melanoma Open

Jessica Guenzle, Harue Akasaka, Katharina Joechle, Wilfried Reichardt, Aïna Venkatasamy , et al. · 2020

Despite recent advances in therapy, liver metastasis from melanoma is still associated with poor prognosis. Although targeting the mTOR signaling pathway exerts potent anti-tumor activity, little is known about specific mTORC2 inhibition r…

β-Arrestin2 is increased in liver fibrosis in humans and rodents Open

Robert Schierwagen, Peter Dietrich, Sabine Klein, Frank Erhard Uschner, Cristina Ortiz , et al. · 2020

Liu et al. (1) elegantly present that β-arrestin2 (β-Arr2) is critical for endothelial nitric oxide synthase (eNOS) activation of liver sinusoidal endothelial cells (LSEC). The authors demonstrate a relationship between decreased β-Arr2 ex…

Neprilysin-neuropeptide Y axis as a target for treatment of liver fibrosis and portal hypertension Open

Cristina Ortíz, Sabine Klein, Winfried Reul, Fernando Magdaleno, Stefanie Gröschl , et al. · 2020

Crucial role of beta-arrestin-2 in linking fibrogenesis and cancer Open

Robert Schierwagen, Peter Dietrich, Judith Heinzen, Sabine Klein, Frank Erhard Uschner , et al. · 2020

Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview Open

Sandra Torres, Zeinab Abdullah, Maximilian Joseph Brol, Claus Hellerbrand, Mercedes Fernández , et al. · 2020

Molecular and cellular research modalities for the study of liver pathologies have been tremendously improved over the recent decades. Advanced technologies offer novel opportunities to establish cell isolation techniques with excellent pu…

Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma Open

Tatjana Seitz, K Freese, Peter Dietrich, Wolfgang E. Thasler, Anja‐Katrin Bosserhoff , et al. · 2020

Hepatocellular carcinoma (HCC) is closely associated with liver fibrosis. Hepatic stellate cells (HSC) and cancer-associated myofibroblasts are key players in liver fibrogenesis and hepatocarcinogenesis. Overexpression of fibroblast growth…

BMP-9 Modulates the Hepatic Responses to LPS Open

H Gaitantzi, J Karch, Lena Germann, Chen Cai, Vanessa Rausch , et al. · 2020

It was previously shown that Bone Morphogenetic Protein (BMP)-9 is constitutively produced and secreted by hepatic stellate cells (HSC). Upon acute liver damage, BMP-9 expression is transiently down-regulated and blocking BMP-9 under condi…

Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer Open

Peter Dietrich, Laura Wormser, Valerie Fritz, Tatjana Seitz, Monica De Maria , et al. · 2020

Hepatocellular carcinoma (HCC) is clearly age-related and represents one of the deadliest cancer types worldwide. As a result of globally increasing risk factors including metabolic disorders, the incidence rates of HCC are still rising. H…

Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury Open

Judith Sommer, Christoph Dorn, Erwin Gäbele, Frauke Bataille, K Freese , et al. · 2020

Cholestasis occurs in different clinical circumstances and leads to severe hepatic disorders. The four-and-a-half LIM-domain protein 2 (FHL2) is a scaffolding protein that modulates multiple signal transduction pathways in a tissue- and ce…

Claus Hellerbrand YOU? Author Swipe