Claus Tempelmann
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View article: Study protocol: value of 7-T MRI with prospective motion correction and postprocessing for patients with nonlesional epilepsy
Study protocol: value of 7-T MRI with prospective motion correction and postprocessing for patients with nonlesional epilepsy Open
The diagnostic yield of magnetic resonance imaging (MRI) postprocessing using 7‑T data for patients with nonlesional epilepsy has been rarely evaluated, but has shown acceptable diagnostic outcomes. However, to date there have been no pros…
Mapping Visual Field Defects With fMRI – Impact of Approach and Experimental Conditions Open
Current initiatives to restore vision emphasize the need for objective assessments of visual field (VF) defects as pursued with functional magnetic resonance imaging (fMRI) approaches. Here, we compared population receptive field (pRF) map…
Functional Dynamics of Deafferented Early Visual Cortex in Glaucoma Open
In advanced retinitis pigmentosa with retinal lesions, the lesion projection zone (LPZ) in the early visual cortex can be driven during visual tasks, while it remains unresponsive during passive viewing. We tested whether this finding tran…
Increased Hippocampal Excitability and Altered Learning Dynamics Mediate Cognitive Mapping Deficits in Human Aging Open
Learning the spatial layout of a novel environment is associated with dynamic activity changes in the hippocampus and in medial parietal areas. With advancing age, the ability to learn spatial environments deteriorates substantially but th…
Functional dynamics of de-afferented early visual cortex in glaucoma Open
fMRI studies in macular degeneration (MD) and retinitis pigmentosa (RP) demonstrated that responses in the lesion projection zones (LPZ) of V1 are task related, indicating significant limits of bottom-up visual system plasticity in MD and …
Peripheral Nerve Imaging Aids in the Diagnosis of Immune-Mediated Neuropathies—A Case Series Open
Background: Diagnosis of immune-mediated neuropathies and their differentiation from amyotrophic lateral sclerosis (ALS) can be challenging, especially at early disease stages. Accurate diagnosis is, however, important due to the different…
Reinstatement of cortical outcome representations during higher-order learning Open
Naturalistic learning scenarios are characterized by infrequent experience of external feedback to guide behavior. Higher-order learning mechanisms like second-order conditioning (SOC) may allow stimuli that were never experienced together…
Macroscopic information-based taste representations in insular cortex are shaped by stimulus concentration Open
Taste processing is an essential ability in all animals signaling potential harm or benefit of ingestive behavior. However, current evidence for cortical taste representations remains contradictory. To address this issue, high-resolution f…
7T MR neurography‐ultrasound fusion for peripheral nerve imaging Open
Background We present one patient with an initial diagnosis of Guillain‐Barré syndrome (GBS) and one with Charcot–Marie–Tooth disease (CMT) type 1A. Methods Both patients underwent ankle tibial nerve fusion‐imaging of high‐resolution ultra…
Decisions bias future choices by modifying hippocampal associative memories Open
Decision making is guided by memories of option values. However, retrieving items from memory renders them malleable. Here, we show that merely retrieving values from memory and making a choice between options is sufficient both to induce …
Information-based taste maps in insular cortex are shaped by stimulus concentration Open
Taste processing is an essential ability in all animals signaling potential harm or benefit of ingestive behavior. Although the peripheral taste coding is well understood, current evidence for central taste processing remains contradictory…
Increased hippocampal excitability and altered learning dynamics mediate cognitive mapping deficits in human aging Open
Learning the spatial layout of a novel environment is associated with dynamic activity changes in the hippocampus and in medial parietal areas. With advancing age, the ability to learn spatial environments deteriorates substantially but th…
The anterior insula channels prefrontal expectancy signals during affective processing Open
Expectancy shapes our perception of impending events. Although such an interplay between cognitive and affective processes is often impaired in mental disorders, it is not well understood how top-down expectancy signals modulate future aff…
View article: Evidence for allocentric boundary and goal direction information in the human entorhinal cortex and subiculum
Evidence for allocentric boundary and goal direction information in the human entorhinal cortex and subiculum Open
In rodents, cells in the medial entorhinal cortex (EC) and subiculum code for the allocentric direction to environment boundaries, which is an important prerequisite for accurate positional coding. Although in humans boundary-related signa…
Motion and physiological noise effects on amygdala real-time fMRI neurofeedback learning Open
Real-time fMRI neurofeedback allows to learn control over activity in a localized brain region. However, with fMRI, physiological factors such as the cardiac cycle and respiration interfere with the measurement of brain activation. In conv…
The effect of acquisition resolution on orientation decoding from V1: comparison of 3T and 7T Open
Previously published results indicate that the accuracy of decoding visual orientation from 7 Tesla fMRI data of V1 peaks at spatial acquisition resolutions that are routinely accessible with more conventional 3 Tesla scanners. This study …
How task demands shape brain responses to visual food cues Open
Several previous imaging studies have aimed at identifying the neural basis of visual food cue processing in humans. However, there is little consistency of the functional magnetic resonance imaging (fMRI) results across studies. Here, we …
Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop Open
Humans constantly learn in the absence of explicit rewards. However, the neurobiological mechanisms supporting this type of internally-guided learning (without explicit feedback) are still unclear. Here, participants who completed a task i…
Author response: Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1 Appendix 2 Appendix 3 References Decision letter Author response Article and author information Metrics Abstract Humans constan…