Clayton A. Whitmore
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View article: Targeting soluble amyloid-beta oligomers with a novel nanobody
Targeting soluble amyloid-beta oligomers with a novel nanobody Open
View article: Synthesis and Evaluation of a Novel PET Radioligand for Imaging Glutaminyl Cyclase Activity as a Biomarker for Detecting Alzheimer’s Disease
Synthesis and Evaluation of a Novel PET Radioligand for Imaging Glutaminyl Cyclase Activity as a Biomarker for Detecting Alzheimer’s Disease Open
Several new lines of research have demonstrated that a significant number of amyloid-β peptides found in Alzheimer's disease (AD) are truncated and undergo post-translational modification by glutaminyl cyclase (QC) at the N-terminal. Notab…
View article: Targeting Soluble Amyloid-Beta Oligomers With a Novel Nanobody
Targeting Soluble Amyloid-Beta Oligomers With a Novel Nanobody Open
The classical amyloid cascade hypothesis postulates that the aggregation of amyloid plaques and the accumulation of intracellular hyperphosphorylated Tau tangles, together, lead to profound neuronal death. However, emerging research has de…
View article: Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer’s disease
Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer’s disease Open
Introduction Ergothioneine (Ergo) is a naturally occurring dietary antioxidant. Ergo uptake is dependent on the transporter, organic cation transporter novel-type 1 (OCTN1) distribution. OCTN1 is highly expressed in blood cells (myeloid li…
View article: Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer’s Disease
Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer’s Disease Open
Background: Ergothioneine (ERGO) is a unique antioxidant and a rare amino acid available in fungi and various bacteria but not in higher plants or animals. Substantial research data indicate that ERGO is a physiological antioxidant cytopro…
View article: Improved synthesis of an ergothioneine PET radioligand for imaging oxidative stress in Alzheimer’s disease
Improved synthesis of an ergothioneine PET radioligand for imaging oxidative stress in Alzheimer’s disease Open
L‐ergothioneine (ERGO) is a potent antioxidant with cytoprotective effects. To study ERGO biodistribution and detect oxidative stress in vivo , we report an efficient and reproducible preparation of [ 11 C]‐labeled ERGO PET radioligand bas…
View article: A novel antioxidant ergothioneine PET radioligand for in vivo imaging applications
A novel antioxidant ergothioneine PET radioligand for in vivo imaging applications Open
View article: Design, Synthesis, and Validation of a Novel [11C]Promethazine PET Probe for Imaging Abeta Using Autoradiography
Design, Synthesis, and Validation of a Novel [11C]Promethazine PET Probe for Imaging Abeta Using Autoradiography Open
Promethazine, an antihistamine drug used in the clinical treatment of nausea, has been demonstrated the ability to bind Abeta in a transgenic mouse model of Alzheimer’s disease. However, so far, all of the studies were performed in vitro u…
View article: Inhalable Thioflavin S for the Detection of Amyloid Beta Deposits in the Retina
Inhalable Thioflavin S for the Detection of Amyloid Beta Deposits in the Retina Open
We present an integrated delivery technology herein employing the aerosolized method to repurpose thioflavin S for imaging amyloid beta (Abeta) deposits in the retina as a surrogate of Abeta in the brain for early detection of Alzheimer’s …