Clayton R. Morrison
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View article: Chikungunya Virus: Current Perspectives on a Reemerging Virus.
Chikungunya Virus: Current Perspectives on a Reemerging Virus. Open
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus in the family Togaviridae that causes outbreaks of debilitating acute and chronic arthralgia in humans. Although historically associated with localized outbreaks in Africa and Asia, …
View article: Using SHAPE-MaP To Model RNA Secondary Structure and Identify 3'UTR Variation in Chikungunya Virus.
Using SHAPE-MaP To Model RNA Secondary Structure and Identify 3'UTR Variation in Chikungunya Virus. Open
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus associated with debilitating arthralgia in humans. RNA secondary structure in the viral genome plays an important role in the lifecycle of alphaviruses; however, the specific role of…
View article: Genetic regulation of homeostatic immune architecture in the lungs of Collaborative Cross mice
Genetic regulation of homeostatic immune architecture in the lungs of Collaborative Cross mice Open
Summary Variation in immune homeostasis, immune system stability, in organ systems such as the lungs is likely to shape the host response to infection at these exposed tissues. We evaluated immune homeostasis in immune cell populations in …
View article: Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors
Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors Open
A benzo[6]annulene, 4-(tert-butyl)-N-(3-methoxy-5,6,7,8-tetrahydronaphthalen-2-yl) benzamide (1a), was identified as an inhibitor against Chikungunya virus (CHIKV) with antiviral activity EC90 = 1.45 μM and …
View article: Immune Predictors of Mortality After Ribonucleic Acid Virus Infection
Immune Predictors of Mortality After Ribonucleic Acid Virus Infection Open
Background Virus infections result in a range of clinical outcomes for the host, from asymptomatic to severe or even lethal disease. Despite global efforts to prevent and treat virus infections to limit morbidity and mortality, the continu…
View article: Using SHAPE-MaP To Model RNA Secondary Structure and Identify 3′UTR Variation in Chikungunya Virus
Using SHAPE-MaP To Model RNA Secondary Structure and Identify 3′UTR Variation in Chikungunya Virus Open
Chikungunya virus (CHIKV) is a mosquito-borne RNA virus that causes febrile illness and debilitating arthralgia in humans. CHIKV causes explosive outbreaks but there are no approved therapies to treat or prevent CHIKV infection. The CHIKV …
View article: Structural divergence creates new functional features in alphavirus genomes
Structural divergence creates new functional features in alphavirus genomes Open
Alphaviruses are mosquito-borne pathogens that cause human diseases ranging from debilitating arthritis to lethal encephalitis. Studies with Sindbis virus (SINV), which causes fever, rash, and arthralgia in humans, and Venezuelan equine en…
View article: Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross
Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross Open
Noll et al. use the Collaborative Cross, a mouse genetic reference population, to map genetic loci associated with variation in the humoral response to influenza virus infection. Cross-dataset comparison shows that mapped loci are importan…
View article: Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology
Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology Open
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis and arthralgia over the past decade. These include a recent outbreak in the Caribbean island…
View article: Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross
Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross Open
Using the Collaborative Cross, a population of recombinant inbred mouse strains with high levels of genetic variation, we measured antibody response and weight change after infection with influenza-A virus.
View article: Bayesian Diallel analysis reveals MX1-dependent and MX1-independent effects on response to influenza a virus in mice
Bayesian Diallel analysis reveals MX1-dependent and MX1-independent effects on response to influenza a virus in mice Open
Influenza A virus (IAV) is a respiratory pathogen that causes substantial morbidity and mortality during both seasonal and pandemic outbreaks. Infection outcomes in unexposed populations are affected by host genetics, but the host genetic …
View article: Immune predictors of mortality following RNA virus infection
Immune predictors of mortality following RNA virus infection Open
Background Virus infections result in a range of clinical outcomes for the host, from asymptomatic to severe or even lethal disease. Despite global efforts to prevent and treat virus infections to limit morbidity and mortality, the continu…
View article: Universal Immune Predictors of Mortality Following Virus Infection
Universal Immune Predictors of Mortality Following Virus Infection Open
View article: Structural divergence creates new functional features in alphavirus genomes
Structural divergence creates new functional features in alphavirus genomes Open
Alphaviruses are mosquito-borne pathogens that cause human diseases ranging from debilitating arthritis to lethal encephalitis. Studies with Sindbis virus (SINV), which causes fever, rash, and arthralgia in humans, and Venezuelan equine en…
View article: Bayesian Diallel Analysis Reveals <i>Mx1</i> -Dependent and <i>Mx1</i> -Independent Effects on Response to Influenza A Virus in Mice
Bayesian Diallel Analysis Reveals <i>Mx1</i> -Dependent and <i>Mx1</i> -Independent Effects on Response to Influenza A Virus in Mice Open
Influenza A virus (IAV) is a respiratory pathogen that causes substantial morbidity and mortality during both seasonal and pandemic outbreaks. Infection outcomes in unexposed populations are affected by host genetics, but the host genetic …
View article: Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology
Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology Open
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis and arthralgia over the past decade. These include a recent outbreak in the Caribbean island…
View article: Diallel analysis reveals<i>Mx1</i>-dependent and<i>Mx1</i>-independent effects on response to influenza A virus in mice
Diallel analysis reveals<i>Mx1</i>-dependent and<i>Mx1</i>-independent effects on response to influenza A virus in mice Open
1. ABSTRACT Influenza A virus (IAV) is a respiratory pathogen that causes substantial morbidity and mortality during both seasonal and pandemic outbreaks. Infection outcomes in unexposed populations are affected by host genetics, but this …
View article: Diallel Analysis Reveals Mx1-Dependent And Mx1-Independent Effects On Response To Influenza A Virus In Mice
Diallel Analysis Reveals Mx1-Dependent And Mx1-Independent Effects On Response To Influenza A Virus In Mice Open
Data and analysis files for diallel analysis of weight loss in 8-12 week old male and female mice (n=1,043), mock treated or infected with influenza A virus (H1N1, PR8) across 4 days post-infection, as well as founder haplotype effect anal…
View article: Diallel Analysis Reveals Mx1-Dependent And Mx1-Independent Effects On Response To Influenza A Virus In Mice
Diallel Analysis Reveals Mx1-Dependent And Mx1-Independent Effects On Response To Influenza A Virus In Mice Open
Data and analysis files for diallel analysis of weight loss in 8-12 week old male and female mice (n=1,043), mock treated or infected with influenza A virus (H1N1, PR8) across 4 days post-infection, as well as founder haplotype effect anal…
View article: Chikungunya Virus: Current Perspectives on a Reemerging Virus
Chikungunya Virus: Current Perspectives on a Reemerging Virus Open
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus in the family Togaviridae that causes outbreaks of debilitating acute and chronic arthralgia in humans. Although historically associated with localized outbreaks in Africa and Asia, …
View article: CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection
CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection Open