Cleandra Gregório
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View article: A Breast Cancer Polygenic Risk Score Validation in 15,490 Brazilians Using Exome Sequencing
A Breast Cancer Polygenic Risk Score Validation in 15,490 Brazilians Using Exome Sequencing Open
Background/Objectives: Brazil has a highly admixed population. Polygenic risk scores (PRSs) have mostly been developed from European population studies, and their application to other populations is challenging. To assess the use of PRS fo…
View article: A Breast Cancer Polygenic Risk Score Validation in 15,490 Brazilians using Exome Sequencing
A Breast Cancer Polygenic Risk Score Validation in 15,490 Brazilians using Exome Sequencing Open
Background Brazil has a highly admixed population. Polygenic Risk Scores (PRS) have mostly been developed from European population studies, and their application to other populations is challenging. To assess the use of PRS for breast canc…
View article: Assessment of Telomere Length and Molecular Characterization of TERT Gene Promoter in Periampullary Carcinomas
Assessment of Telomere Length and Molecular Characterization of TERT Gene Promoter in Periampullary Carcinomas Open
Genetic and epigenetic alterations of the telomere maintenance machinery like telomere length and telomerase reverse transcriptase (encoded by TERT gene) are reported in several human malignancies. However, there is limited knowledge on th…
View article: Calcium Signaling Alterations Caused by Epigenetic Mechanisms in Pancreatic Cancer: From Early Markers to Prognostic Impact
Calcium Signaling Alterations Caused by Epigenetic Mechanisms in Pancreatic Cancer: From Early Markers to Prognostic Impact Open
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with high mortality rates. PDAC initiation and progression are promoted by genetic and epigenetic dysregulation. Here, we aimed to characterize the PDAC DNA methylome in sear…
View article: Synchronous Periampullary Tumors in a Patient With Pancreas Divisum and Neurofibromatosis Type 1
Synchronous Periampullary Tumors in a Patient With Pancreas Divisum and Neurofibromatosis Type 1 Open
This is the first report of a Neurofibromatosis type 1 patient with pancreas divisum and multiple periampullary tumors harboring pathogenic germline variants in NF1 and CFTR genes. The identification of two germline variants and a developm…
View article: Correction: BRCA1 and BRCA2 mutational profile and prevalence in hereditary breast and ovarian cancer (HBOC) probands from Southern Brazil: Are international testing criteria appropriate for this specific population?
Correction: BRCA1 and BRCA2 mutational profile and prevalence in hereditary breast and ovarian cancer (HBOC) probands from Southern Brazil: Are international testing criteria appropriate for this specific population? Open
[This corrects the article DOI: 10.1371/journal.pone.0187630.].
View article: BRCA1 and BRCA2 mutational profile and prevalence in hereditary breast and ovarian cancer (HBOC) probands from Southern Brazil: Are international testing criteria appropriate for this specific population?
BRCA1 and BRCA2 mutational profile and prevalence in hereditary breast and ovarian cancer (HBOC) probands from Southern Brazil: Are international testing criteria appropriate for this specific population? Open
This is the largest study of comprehensive BRCA testing among Brazilians to date, and the first to analyze clinical criteria for genetic testing. Several criteria that are not included in the NCCN achieved a higher predictive value. Identi…
Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver Open
Data suggest that inflammatory signaling and ultrastructural alterations play a significant role during hepatic steatosis in zebrafish chronically exposed to ethanol.