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View article: P05.06.B CLINICAL USEFULNESS OF MGMT PROMOTER METHYLATION QUANTIFICATION IN GBM PATIENTS TREATED WITH CHEMO-RADIATION THERAPY
P05.06.B CLINICAL USEFULNESS OF MGMT PROMOTER METHYLATION QUANTIFICATION IN GBM PATIENTS TREATED WITH CHEMO-RADIATION THERAPY Open
BACKGROUND In glioblastoma (GBM) patients two factors are relevant for prediction of survival: MGMT promoter hypermethylation, which improves the patient’s response to temozolomide (TMZ), and the extent of resection (EOR), with a better ov…
View article: The Evolution of Telemedicine in Pre-Post COVID-19 Period
The Evolution of Telemedicine in Pre-Post COVID-19 Period Open
Introduction In recent years, telemedicine has become increasingly widespread, with a marked rise in adoption during the COVID-19 pandemic. During the period of restrictions, telemedicine resulted to be particularly useful for managing var…
View article: Testing for causal effect for binary data when propensity scores are estimated through Bayesian Networks
Testing for causal effect for binary data when propensity scores are estimated through Bayesian Networks Open
This paper proposes a new statistical approach for assessing treatment effect using Bayesian Networks (BNs). The goal is to draw causal inferences from observational data with a binary outcome and discrete covariates. The BNs are here used…
View article: Usability of machine learning algorithms based on electronic health records for the prediction of acute kidney injury and transition to acute kidney disease: A proof of concept study
Usability of machine learning algorithms based on electronic health records for the prediction of acute kidney injury and transition to acute kidney disease: A proof of concept study Open
Background Acute kidney injury (AKI) and acute kidney disease (AKD) are frequent complications of hospitalization, resulting in reduced outcomes and increased cost burden. However, these conditions are only sometimes recognized and promptl…
View article: A Retrospective Assessment of Computed Tomography-Based Body Composition and Toxicity in Ovarian Cancer Patients Treated with PARP Inhibitors
A Retrospective Assessment of Computed Tomography-Based Body Composition and Toxicity in Ovarian Cancer Patients Treated with PARP Inhibitors Open
Objectives: The objective of this single-site retrospective study was to assess the association between Computed Tomography (CT)-based whole-body composition values with dose reduction in patients with a diagnosis of epithelial ovarian can…
View article: Immune signature in vaccinated versus non-vaccinated aged people with COVID-19 pneumonia
Immune signature in vaccinated versus non-vaccinated aged people with COVID-19 pneumonia Open
Background A definition of the immunological features of COVID-19 pneumonia is needed to support clinical management of aged patients. In this study, we characterized the humoral and cellular immune responses in presence or absence of SARS…
View article: Long-term and real-world safety and efficacy of retroviral gene therapy for adenosine deaminase deficiency
Long-term and real-world safety and efficacy of retroviral gene therapy for adenosine deaminase deficiency Open
View article: Optimizing CO2 field flooding during sternotomy: In vitro confirmation of the Karolinska studies
Optimizing CO2 field flooding during sternotomy: In vitro confirmation of the Karolinska studies Open
Although CO 2 field-flooding was first used during cardiac surgery more than 60 years ago, its efficacy is still disputed. The invisible nature of the gas and the difficulty in determining the “safe” quantity to protect the patient are two…
View article: Current state-of-the-art and gaps in platform trials: 10 things you should know, insights from EU-PEARL
Current state-of-the-art and gaps in platform trials: 10 things you should know, insights from EU-PEARL Open
Innovative Medicines Initiative 2 Joint Undertaking with support from the European Union's Horizon 2020 research and innovation programme and EFPIA.
View article: Differential impact of transfusion guidelines on blood transfusion practices within a health network
Differential impact of transfusion guidelines on blood transfusion practices within a health network Open
View article: Profiling Covid-19 patients with respect to level of severity: an integrated statistical approach
Profiling Covid-19 patients with respect to level of severity: an integrated statistical approach Open
A full understanding of the characteristics of Covid-19 patients with a better chance of experiencing poor vital outcomes is critical for implementing accurate and precise treatments. In this paper, two different advanced data-driven stati…
View article: Differential impact of transfusion guidelines on blood transfusion practices within a health network
Differential impact of transfusion guidelines on blood transfusion practices within a health network Open
Whether clinical practice guidelines have a significant impact on practice is unclear. The effect of guideline recommendations on clinical practice often a lags behind the date of publication. We evaluated by means of a data-driven approac…
View article: Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia
Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia Open
Acute myeloid leukemia may be characterized by a fraction of leukemia stem cells (LSCs) that sustain disease propagation eventually leading to relapse. Yet, the contribution of LSCs to early therapy resistance and AML regeneration remains …
View article: Testing for causal effect for binary data when propensity scores are estimated through Bayesian Networks
Testing for causal effect for binary data when propensity scores are estimated through Bayesian Networks Open
This paper proposes a new statistical approach for assessing treatment effect using Bayesian Networks (BNs). The goal is to draw causal inferences from observational data with a binary outcome and discrete covariates. The BNs are here used…
View article: Modelling the impact of protein-kinase R allelic variant on HIV biomarkers trajectories by means of latent class mixed models
Modelling the impact of protein-kinase R allelic variant on HIV biomarkers trajectories by means of latent class mixed models Open
This paper is based on a retrospective longitudinal study on people living with HIV under antiretroviral treatment (ART) where allelic variants (either heterozygous CT genotype or homozygous CC genotype) have been evaluated at position −16…
View article: EUS-guided ablation with the HybridTherm Probe as second-line treatment in patients with locally advanced pancreatic ductal adenocarcinoma: A case–control study
EUS-guided ablation with the HybridTherm Probe as second-line treatment in patients with locally advanced pancreatic ductal adenocarcinoma: A case–control study Open
Background and Objectives: Data on the clinical efficacy of EUS-guided ablation using the HybridTherm-Probe (EUS-HTP) in locally advanced pancreatic ductal adenocarcinoma (LA-PDAC) are lacking. The aim of the study was to assess the impact…
View article: AI-SCoRE (artificial intelligence-SARS CoV2 risk evaluation): a fast, objective and fully automated platform to predict the outcome in COVID-19 patients
AI-SCoRE (artificial intelligence-SARS CoV2 risk evaluation): a fast, objective and fully automated platform to predict the outcome in COVID-19 patients Open
View article: The reproducibility of COVID-19 data analysis: paradoxes, pitfalls, and future challenges
The reproducibility of COVID-19 data analysis: paradoxes, pitfalls, and future challenges Open
In the midst of the COVID-19 experience, we learned an important scientific lesson: knowledge acquisition and information quality in medicine depends more on “data quality” rather than “data quantity.” The large number of COVID-19 reports,…
View article: TRACKING HEMATOPOIETIC STEM CELL EVOLUTION IN A WISKOTT-ALDRICH CLINICAL TRIAL
TRACKING HEMATOPOIETIC STEM CELL EVOLUTION IN A WISKOTT-ALDRICH CLINICAL TRIAL Open
Hematopoietic Stem Cells (HSC) are the cells that give rise to all other blood cells and, as such, they are crucial in the healthy development of individuals. Wiskott-Aldrich Syndrome (WAS) is a severe disorder affecting the regulation of …
View article: Multivariate determinants of self-management in Health Care: assessing Health Empowerment Model by comparison between structural equation and graphical models approaches
Multivariate determinants of self-management in Health Care: assessing Health Empowerment Model by comparison between structural equation and graphical models approaches Open
Backgroung. In public health one debated issue is related to consequences of improper self-management in health care. Some theoretical models have been proposed in Health Communication theory which highlight how components such general l…
View article: The role of statisticians in the response to COVID-19 in Israel: a holistic point of view
The role of statisticians in the response to COVID-19 in Israel: a holistic point of view Open
The COVID-19 pandemic cast a dramatic spotlight on the use of data as a fundamental component of good decision-making. Evaluating and comparing alternative policies required information on concurrent infection rates and insightful analysis…
View article: Reply to Gremese et al.: Statistical reasoning to evaluate treatment effects when data are collected with lack of design: Covid-19 experience
Reply to Gremese et al.: Statistical reasoning to evaluate treatment effects when data are collected with lack of design: Covid-19 experience Open
Gremese et al. (1) argue that “more data” are needed to assess the effects of treatments in patients with COVID-19. A major lesson gained from the torrent of publications on COVID-19 (>200,000 in 2 y) concerns the importance of the quality…
View article: Hematopoietic Tumors in a Mouse Model of X-linked Chronic Granulomatous Disease after Lentiviral Vector-Mediated Gene Therapy
Hematopoietic Tumors in a Mouse Model of X-linked Chronic Granulomatous Disease after Lentiviral Vector-Mediated Gene Therapy Open
Chronic granulomatous disease (CGD) is a rare inherited disorder due to loss-of-function mutations in genes encoding the NADPH oxidase subunits. Hematopoietic stem and progenitor cell (HSPC) gene therapy (GT) using regulated lentiviral vec…
View article: Hematopoietic Tumors in a Mouse Model of X-linked Chronic Granulomatous Disease after Lentiviral Vector-Mediated Gene Therapy
Hematopoietic Tumors in a Mouse Model of X-linked Chronic Granulomatous Disease after Lentiviral Vector-Mediated Gene Therapy Open
Chronic granulomatous disease (CGD) is a rare inherited disorder due to loss-of-function mutations in genes encoding the NADPH oxidase subunits. Hematopoietic stem and progenitor cell (HSPC) gene therapy (GT) using regulated lentiviral vec…
View article: Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access Open
Orchard Therapeutics, Fondazione Telethon, and GlaxoSmithKline.
View article: Profiling Antibody Response Patterns in COVID-19: Spike S1-Reactive IgA Signature in the Evolution of SARS-CoV-2 Infection
Profiling Antibody Response Patterns in COVID-19: Spike S1-Reactive IgA Signature in the Evolution of SARS-CoV-2 Infection Open
This contribution explores in a new statistical perspective the antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 141 coronavirus disease 2019 (COVID-19) patients exhibiting a broad range of clinical man…
View article: CXCL10 levels at hospital admission predict COVID-19 outcome: hierarchical assessment of 53 putative inflammatory biomarkers in an observational study
CXCL10 levels at hospital admission predict COVID-19 outcome: hierarchical assessment of 53 putative inflammatory biomarkers in an observational study Open
Background Host inflammation contributes to determine whether SARS-CoV-2 infection causes mild or life-threatening disease. Tools are needed for early risk assessment. Methods We studied in 111 COVID-19 patients prospectively followed at a…
View article: Saliva molecular testing for SARS-CoV-2: simplifying the diagnosis without losing accuracy
Saliva molecular testing for SARS-CoV-2: simplifying the diagnosis without losing accuracy Open
This study demonstrated that the use of point of care technologies on saliva represents a valid and highly specific solution to simplify, speed up and broadly distribute the diagnostic process for the control of the COVID-19 epidemic https…
View article: Altered Frequency and Phenotype of HLA-G-Expressing DC-10 in Type 1 Diabetes Patients at Onset and in Subjects at Risk to Develop the Disease
Altered Frequency and Phenotype of HLA-G-Expressing DC-10 in Type 1 Diabetes Patients at Onset and in Subjects at Risk to Develop the Disease Open
Type 1 diabetes (T1D) is a chronic autoimmune disease resulting in progressive destruction of β-cells. Several factors affecting lymphocyte and antigen-presenting cells, including dendritic cells (DCs), contribute to defective maintenance …
View article: SARS-CoV-2 Antibody Rapid Tests: Valuable Epidemiological Tools in Challenging Settings
SARS-CoV-2 Antibody Rapid Tests: Valuable Epidemiological Tools in Challenging Settings Open
Our study provides a fresh perspective on the possible employment of SARS-CoV-2 LFA antibody tests. We developed an in-depth, large-scale analysis comparing LFA performance to enzyme-linked immunosorbent assay (ELISA) and electrochemilumin…