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View article: International reporting guidelines for tear fluid research: A Delphi consensus
International reporting guidelines for tear fluid research: A Delphi consensus Open
The TEAR-reporting guidelines (TEAR-RG) represent a significant step toward standardizing research practices in tear fluid studies. By addressing key methodological and reporting issues, these guidelines aim to improve the reproducibility …
View article: Mineralocorticoid receptor antagonism improves corneal integrity in a rat model of limbal stem cell deficiency
Mineralocorticoid receptor antagonism improves corneal integrity in a rat model of limbal stem cell deficiency Open
Limbal stem cell deficiency (LSCD) is a sight-threatening condition caused by the loss and/or dysfunction of limbal stem cells (LSCs), which are essential for corneal epithelial regeneration and homeostasis and are critical for maintaining…
View article: Positive cooperativity in synergistic activation of Wnt proteins
Positive cooperativity in synergistic activation of Wnt proteins Open
Background Wnt proteins are crucial for embryonic development, stem cell growth, and tissue regeneration. Wnt signaling pathway is activated when Wnt proteins bind to cell membrane receptors. Methods and results We employed a luciferase re…
View article: Descemet Stripping Endothelial Keratoplasty in Patients With a Custom Foldable Silicone Artificial Iris: Safety and Efficacy Outcomes
Descemet Stripping Endothelial Keratoplasty in Patients With a Custom Foldable Silicone Artificial Iris: Safety and Efficacy Outcomes Open
Purpose: To assess outcomes of Descemet stripping endothelial keratoplasty (DSEK) in eyes with custom artificial iris (CAI) implantation. Methods: This is a retrospective, interventional, consecutive, surgical case series of patients who u…
View article: Latent diffusion augmentation enhances deep learning analysis of neuro-morphology in limbal stem cell deficiency
Latent diffusion augmentation enhances deep learning analysis of neuro-morphology in limbal stem cell deficiency Open
Introduction Limbal Stem Cell Deficiency (LSCD) is a blinding corneal disease characterized by the loss of function or deficiency in adult stem cells located at the junction between the cornea and the sclera (i.e., the limbus), namely the …
View article: Wnt activation as a potential therapeutic approach to treat partial limbal stem cell deficiency
Wnt activation as a potential therapeutic approach to treat partial limbal stem cell deficiency Open
Limbal epithelial stem/progenitor cells (LSCs) are adult stem cells located at the limbus, tightly regulated by their niche involving numerous signaling pathways, such as Wnt. Wnt proteins are secreted morphogens that play critical roles i…
View article: Ocular Surface Regeneration by Limbal Stem Cells Therapies: State of the Art, Challenges, and Perspectives
Ocular Surface Regeneration by Limbal Stem Cells Therapies: State of the Art, Challenges, and Perspectives Open
Limbal stem cells (LSCs) are adult stem cells located at the limbus ensuring the continuous renewal of the corneal epithelium, critical to maintain an optimal visual function. Damages to the LSCs or their niche microenvironment lead to lim…
View article: Big data and artificial intelligence in ophthalmology - clinical application and future exploration
Big data and artificial intelligence in ophthalmology - clinical application and future exploration Open
it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed.The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge.Front…
View article: Descemet membrane endothelial keratoplasty in eyes with glaucoma
Descemet membrane endothelial keratoplasty in eyes with glaucoma Open
Endothelial keratoplasty has become the standard for the treatment of endothelial dysfunction. In Descemet membrane endothelial keratoplasty (DMEK), only the endothelium and Descemet membrane are transplanted, providing superior outcomes c…
View article: Autologous Serum Eye Drops in the Management of Limbal Stem Cell Deficiency Associated With Glaucoma Surgery
Autologous Serum Eye Drops in the Management of Limbal Stem Cell Deficiency Associated With Glaucoma Surgery Open
Purpose: To evaluate safety and efficacy of autologous serum eye drops (AS) in the treatment of limbal stem cell deficiency (LSCD) associated with glaucoma surgery. Methods: Retrospective case series of eyes with glaucoma surgery-induced L…
View article: The StarvAnx Study-Comparison Between the Effects of Non-fasting Vs. Fasting Strategy on Surgical Outcomes, Anxiety and Pain in Patients Undergoing Cataract Surgery Under Topical Anesthesia: A Randomized, Crossover, Controlled Trial
The StarvAnx Study-Comparison Between the Effects of Non-fasting Vs. Fasting Strategy on Surgical Outcomes, Anxiety and Pain in Patients Undergoing Cataract Surgery Under Topical Anesthesia: A Randomized, Crossover, Controlled Trial Open
Background Fasting is usually recommended in patients undergoing cataract surgery under topical anesthesia. However, starving before surgery may increase preoperative anxiety and affect surgical outcomes. It is not known which fasting or n…
View article: Extracellular miR-6723-5p could serve as a biomarker of limbal epithelial stem/progenitor cell population
Extracellular miR-6723-5p could serve as a biomarker of limbal epithelial stem/progenitor cell population Open
Background Dysfunction or loss of limbal stem cells can result in limbal stem cell deficiency (LSCD), a disease that cause corneal opacity, pain, and loss of vision. Cultivated limbal epithelial transplantation (CLET) can be used to restor…
View article: Cell Morphology as an In Vivo Parameter for the Diagnosis of Limbal Stem Cell Deficiency
Cell Morphology as an In Vivo Parameter for the Diagnosis of Limbal Stem Cell Deficiency Open
Purpose: The aim of this study was to investigate basal epithelial cell morphology (CM) in the central cornea and limbal areas of eyes with limbal stem cell deficiency (LSCD). Methods: This was a prospective, cross-sectional comparative st…
View article: Wnt6 plays a complex role in maintaining human limbal stem/progenitor cells
Wnt6 plays a complex role in maintaining human limbal stem/progenitor cells Open
The corneal epithelium is consistently regenerated by limbal stem/progenitor cells (LSCs), a very small population of adult stem cells residing in the limbus. Several Wnt ligands, including Wnt6, are preferentially expressed in the limbus.…
View article: Wnt6 Plays a Complex Role in Maintaining Human Limbal Stem/Progenitor Cells
Wnt6 Plays a Complex Role in Maintaining Human Limbal Stem/Progenitor Cells Open
The cornea is consistently regenerated by limbal stem/progenitor cells (LSCs), a very small population of adult stem cells residing in the limbus. Several Wnt ligands, including Wnt6, are preferentially expressed in the limbus. To investig…
View article: Wnt signaling activation: targets and therapeutic opportunities for stem cell therapy and regenerative medicine
Wnt signaling activation: targets and therapeutic opportunities for stem cell therapy and regenerative medicine Open
Overview of the Wnt signaling pathway and targets of Wnt activators.
View article: Sutured Custom Foldable Silicone Artificial Iris Implantation Combined With Intraocular Lens Implantation and Penetrating Keratoplasty: Safety and Efficacy Outcomes
Sutured Custom Foldable Silicone Artificial Iris Implantation Combined With Intraocular Lens Implantation and Penetrating Keratoplasty: Safety and Efficacy Outcomes Open
Purpose: To assess safety and efficacy outcomes of sutured custom silicone artificial iris and intraocular lens implantation combined with penetrating keratoplasty (triple procedure). Methods: Prospective consecutive surgical case series o…
View article: Femto Laser-Assisted Cataract Surgery
Femto Laser-Assisted Cataract Surgery Open
Cataract is a leading cause of blindness in the world, and cataract extraction is one of the most commonly performed surgeries. Preferred surgical techniques have changed over the past decades with associated improvements in outcomes and s…
View article: Anterior segment optical coherence tomography imaging in peripheral ulcerative keratitis, a corneal structural description
Anterior segment optical coherence tomography imaging in peripheral ulcerative keratitis, a corneal structural description Open
Background Anterior segment optical coherence tomography (AS OCT) is a helpful tool used to diagnose and manage many corneal conditions, but its use has not been reported in case of peripheral ulcerative keratitis (PUK). The aim of this st…
View article: Anterior Segment Optical Coherence Tomography Imaging in Peripheral Ulcerative Keratitis, a Corneal Structural Description
Anterior Segment Optical Coherence Tomography Imaging in Peripheral Ulcerative Keratitis, a Corneal Structural Description Open
Background Anterior-segment optical coherence tomography (AS OCT) is an important tool, helpful to diagnose and manage many corneal conditions, but has not been reported in cases of peripheral ulcerative keratitis (PUK). The aim of this st…
View article: Spectral-Domain Optical Coherence Tomography Imaging in Peripheral Ulcerative Keratitis. A Corneal Structural Description
Spectral-Domain Optical Coherence Tomography Imaging in Peripheral Ulcerative Keratitis. A Corneal Structural Description Open
Background: Anterior-segment optical coherence tomography (AS-OCT) is an important tool, helpful to diagnose and manage many corneal conditions, but has not been reported in cases of peripheral ulcerative keratitis (PUK). The aim of this s…