Charles D. Howell
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View article: Panorama des pathologies infectieuses et non infectieuses de Polynésie française en 2025
Panorama des pathologies infectieuses et non infectieuses de Polynésie française en 2025 Open
Overview of infectious and non-infectious diseases in French Polynesia in 2025 Tahiti or the “myth of Paradise”, Bora Bora, “the Pearl of the Pacific”. Who has never wanted to take a plane and come and land on the heavenly beaches of Polyn…
View article: Transcriptomic Profiling MicroRNA and Non-Coding RNA from Whole Blood in African Americans with MASLD
Transcriptomic Profiling MicroRNA and Non-Coding RNA from Whole Blood in African Americans with MASLD Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing health concern, yet the role of non-coding RNAs (ncRNAs), including microRNAs (miRNAs), in its pathogenesis remains poorly understood. In this pilot study, we ai…
View article: Health system community partnership to design an online resource to address perinatal information needs for Black families: Action research study (Preprint)
Health system community partnership to design an online resource to address perinatal information needs for Black families: Action research study (Preprint) Open
BACKGROUND We aimed to design an online resource hub to provide information to support timely access to care and resources to improve perinatal health outcomes for Black families in Mecklenburg County, the largest metropolitan area in Nor…
View article: A rare case of leukocytoclastic vasculitis in autologous breast augmentation post breast cancer treatment
A rare case of leukocytoclastic vasculitis in autologous breast augmentation post breast cancer treatment Open
Leukocytoclastic vasculitis is a hypersensitivity reaction involving immune complex deposition in dermal capillaries and venules. We report a case of a 34-year-old female patient with left-sided breast carcinoma who developed vasculitis fo…
View article: Nutritional Calorie Labeling and Menu Ordering Practices Among US Adults With Chronic Illnesses
Nutritional Calorie Labeling and Menu Ordering Practices Among US Adults With Chronic Illnesses Open
US adults with chronic illnesses do not pay sufficient attention to the calorie information of their diet. Furthermore, awareness of the calorie information did not influence their dietary choices. Healthcare professionals should incorpora…
View article: Transcriptomic Analysis of Alzheimer’s Disease Pathways in a Pakistani Population
Transcriptomic Analysis of Alzheimer’s Disease Pathways in a Pakistani Population Open
Background: Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder that is most prevalent in elderly individuals, especially in developed countries, and its prevalence is now increasing in developing countries like Pakista…
View article: Transcriptomics of MASLD Pathobiology in African American Patients in the Washington DC Area †
Transcriptomics of MASLD Pathobiology in African American Patients in the Washington DC Area † Open
Metabolic-dysfunction-associated steatotic liver disease (MASLD) is becoming the most common chronic liver disease worldwide and is of concern among African Americans (AA) in the United States. This pilot study evaluated the differential g…
View article: Similarities in Pathobiology of Alzheimer’s Disease and Type 2 Diabetes Mellitus: A Proof of Concept by a Case Study
Similarities in Pathobiology of Alzheimer’s Disease and Type 2 Diabetes Mellitus: A Proof of Concept by a Case Study Open
Background Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Developing countries will have >3 times the prevalence of the developed countries by the year 2050. Our previous studies with a Pakistani population have sugge…
View article: Correlates and Covariates of Type 2 Diabetes in an African American Population in the Washington DC Area
Correlates and Covariates of Type 2 Diabetes in an African American Population in the Washington DC Area Open
In the United States, type 2 diabetes mellitus (T2DM) disproportionately affects the African American (AA) community, which has not been systematically included in molecular studies of underlying mechanisms. As part of a gene expression st…
View article: Signature Genes for Type 2 Diabetes in an African American Population
Signature Genes for Type 2 Diabetes in an African American Population Open
BACKGROUND AND AIM: Diabetes disproportionately affects racial/ethnic minority populations. Type 2 Diabetes Mellitus (T2DM) is viewed as an outcome of the interaction of environmental and biological risk factors. Our previous studies estab…
View article: Peginterferon and Ribavirin Treatment in African American and Caucasian American Patients With Hepatitis C Genotype 1
Peginterferon and Ribavirin Treatment in African American and Caucasian American Patients With Hepatitis C Genotype 1 Open
BACKGROUND & AIMS: Compared with Caucasian Americans (CA), African Americans (AA) with chronic hepatitis C are less likely to respond to interferon-based antiviral therapy. METHODS: In a multicenter treatment trial, 196 AA and 205 CA treat…
View article: Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genotype 1
Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genotype 1 Open
We studied the relationship between IL28B gene-related SNP rs12979860 and early viral kinetics (day 0–28) during peginterferon and ribavirin treatment, in 173 African Americans (AA) and 188 Caucasian Americans (CA) with HCV genotype 1.
View article: Quantitation of Pretreatment Serum IP-10 Improves the Predictive Value of an IL28B Gene Polymorphism for Hepatitis C Treatment Response
Quantitation of Pretreatment Serum IP-10 Improves the Predictive Value of an IL28B Gene Polymorphism for Hepatitis C Treatment Response Open
Polymorphisms of IL28B gene are highly associated with sustained virological response (SVR) in patients with chronic hepatitis C treated with peginterferon and ribavirin. Quantitation of Interferon-γ Inducible Protein-10 (IP-10) may also d…
View article: Association of Patients’ Perception of Quality of Healthcare Received and Colorectal Cancer Screening Uptake: An Analysis of 2 National Surveys in the USA
Association of Patients’ Perception of Quality of Healthcare Received and Colorectal Cancer Screening Uptake: An Analysis of 2 National Surveys in the USA Open
Objective: It is not known whether patients’ ratings of the quality of healthcare services they receive truly correlate with the quality of care from their providers. Understanding this association can potentiate improvement in healthcare …
View article: Patterns of Hepatitis C-Related Inpatient Mortality in the United States in the Era of Direct-Acting Antivirals.
Patterns of Hepatitis C-Related Inpatient Mortality in the United States in the Era of Direct-Acting Antivirals. Open
The burden of HCV infection is substantial given the disease is now curable. Our findings indicate that major disparities in the HCV disease burden exist in the era of DAA.
View article: Using Patients' Social Network to Improve Compliance to Outpatient Screening Colonoscopy Appointments Among Blacks: A Randomized Clinical Trial
Using Patients' Social Network to Improve Compliance to Outpatient Screening Colonoscopy Appointments Among Blacks: A Randomized Clinical Trial Open
OBJECTIVES: Patient navigation improves colorectal cancer screening among underserved populations, but limited resources preclude widespread adoption in minority-serving institutions. We evaluated whether a patient's self-selected social c…
View article: Vitamin D Status and Virologic Response to HCV Therapy in the HALT-C and VIRAHEP-C Trials
Vitamin D Status and Virologic Response to HCV Therapy in the HALT-C and VIRAHEP-C Trials Open
Higher vitamin D status was not beneficially associated with responses to therapy; if anything, patients with higher vitamin D concentrations were less likely to attain SVR. Our data do not support a role for vitamin D supplementation as a…