Clémence Martin
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View article: Nirsevimab Effectiveness Against Intensive Care Unit Admission for Respiratory Syncytial Virus in Infants — 24 States, December 2024–April 2025
Nirsevimab Effectiveness Against Intensive Care Unit Admission for Respiratory Syncytial Virus in Infants — 24 States, December 2024–April 2025 Open
View article: Beyond Trikafta: new models to assess tissue dependent rescue of N1303K-CFTR
Beyond Trikafta: new models to assess tissue dependent rescue of N1303K-CFTR Open
Rationale Respiratory status of people with Cystic Fibrosis (pwCF) carrying N1303K is improved by Elexacaftor/Tezacaftor/Ivacaftor (ETI) but, contrary to other mutations, the impact on sweat test results is limited. Methods To explore this…
View article: Cytosolic proliferating cell nuclear antigen (PCNA) orchestrates neutrophil hyperactivation in COVID-19
Cytosolic proliferating cell nuclear antigen (PCNA) orchestrates neutrophil hyperactivation in COVID-19 Open
Neutrophils are central mediators of the hyperinflammatory response in severe SARS-CoV-2 infection. We report elevated cytosolic levels of proliferating cell nuclear antigen (PCNA) in neutrophils from patients with severe and critical COVI…
View article: Outpatient Parenteral Antimicrobial Therapy in a Tertiary Hospital in France: A Description of Service Models and Costs
Outpatient Parenteral Antimicrobial Therapy in a Tertiary Hospital in France: A Description of Service Models and Costs Open
Background/Objectives: Outpatient parenteral antimicrobial therapy (OPAT) has been implemented throughout the world for the treatment of most infections. Published studies have focused on OPAT delivery, with limited data on coordination an…
View article: Identification of structural predictors of lung function improvement in adults with cystic fibrosis treated with elexacaftor-tezacaftor-ivacaftor using deep-learning
Identification of structural predictors of lung function improvement in adults with cystic fibrosis treated with elexacaftor-tezacaftor-ivacaftor using deep-learning Open
View article: Elexacaftor-tezacaftor-ivacaftor in people with cystic fibrosis harbouring two CFTR Class I variants: real-world data from the French compassionate programme
Elexacaftor-tezacaftor-ivacaftor in people with cystic fibrosis harbouring two CFTR Class I variants: real-world data from the French compassionate programme Open
View article: Bronchiectasis in France: data on disease characteristics in 630 patients from the European Bronchiectasis registry (EMBARC)
Bronchiectasis in France: data on disease characteristics in 630 patients from the European Bronchiectasis registry (EMBARC) Open
In France, adults with bronchiectasis experience significant disease burden. Respiratory exacerbations are responsible for healthcare utilization and their prevention may require specialized multidisciplinary care and the development of no…
View article: Decreased insulin dose-adjusted hemoglobin A1c in adults with cystic fibrosis-related diabetes treated with elexacaftor-tezacaftor-ivacaftor
Decreased insulin dose-adjusted hemoglobin A1c in adults with cystic fibrosis-related diabetes treated with elexacaftor-tezacaftor-ivacaftor Open
A numerically significant association between ETI and IDAA1c decrease was observed in adults with established CFRD after 24 months of treatment, suggesting ETI contributed to improved glycemic control.
View article: Cystic Fibrosis Microbiome-directed Antibiotic Therapy Trial in Exacerbations Results Stratified (CFMATTERS): results of a multicentre randomised controlled trial
Cystic Fibrosis Microbiome-directed Antibiotic Therapy Trial in Exacerbations Results Stratified (CFMATTERS): results of a multicentre randomised controlled trial Open
Background This study explores the effectiveness and safety of microbiome-directed antimicrobial therapy versus usual antimicrobial therapy in adult cystic fibrosis pulmonary exacerbations. Methods A multicentre two-arm parallel randomised…
View article: CFTR modulators and pregnancy outcomes: Early findings from a nationwide cohort study
CFTR modulators and pregnancy outcomes: Early findings from a nationwide cohort study Open
View article: Neutrophils Display Novel Partners of Cytosolic Proliferating Cell Nuclear Antigen Involved in Interferon Response in COVID-19 Patients
Neutrophils Display Novel Partners of Cytosolic Proliferating Cell Nuclear Antigen Involved in Interferon Response in COVID-19 Patients Open
Introduction: Neutrophils are key players in the hyperinflammatory response during SARS-CoV-2 infection. The cytosolic proliferating cell nuclear antigen (PCNA) is a scaffolding protein highly dependent on the microenvironment status and k…
View article: Beta-adrenergic sweat test in challenging cystic fibrosis diagnosis.
Beta-adrenergic sweat test in challenging cystic fibrosis diagnosis. Open
View article: The expanded French compassionate programme for elexacaftor–tezacaftor–ivacaftor use in people with cystic fibrosis without a F508del CFTR variant: a real-world study
The expanded French compassionate programme for elexacaftor–tezacaftor–ivacaftor use in people with cystic fibrosis without a F508del CFTR variant: a real-world study Open
View article: Imaging findings of thoracic manifestations of Crohn’s disease and ulcerative colitis
Imaging findings of thoracic manifestations of Crohn’s disease and ulcerative colitis Open
View article: New drugs, new challenges in cystic fibrosis care
New drugs, new challenges in cystic fibrosis care Open
Cystic fibrosis (CF) is a genetic disease caused by variants in the gene encoding for the CF transmembrane conductance regulator (CFTR) protein, a chloride and bicarbonate channel. CFTR dysfunction results in a multiorgan disease with the …
View article: Beyond Kaftrio : mechanistic insights to maximize N1303K-CFTR rescue
Beyond Kaftrio : mechanistic insights to maximize N1303K-CFTR rescue Open
Introduction N1303K is the fourth most frequent Cystic Fibrosis (CF) causing mutation. People with CF (pwCF) clinical status can be improved by Elexacaftor(ELX)/Tezacaftor(TEZ)/Ivacaftor (ETI) combotherapy. We investigated the mechanism un…
View article: Standards for the care of people with cystic fibrosis (CF); recognising and addressing CF health issues
Standards for the care of people with cystic fibrosis (CF); recognising and addressing CF health issues Open
This is the third in a series of four papers updating the European Cystic Fibrosis Society (ECFS) standards for the care of people with CF. This paper focuses on recognising and addressing CF health issues. The guidance was produced with w…
View article: 306 Mutations at the rare cystic fibrosis site arginine-933 form folded CFTR by cryogenic electron microscopy
306 Mutations at the rare cystic fibrosis site arginine-933 form folded CFTR by cryogenic electron microscopy Open
View article: CT imaging shows specific pancreatic abnormalities in persons with cystic fibrosis related diabetes
CT imaging shows specific pancreatic abnormalities in persons with cystic fibrosis related diabetes Open
Cystic fibrosis related diabetes (CFRD) is observed in 20–50% of adults with cystic fibrosis (CF). Pancreas abnormalities on imaging, e.g. pancreas lipomatosis, are frequent in subjects with CF. We hypothesized that specific abnormalities …
View article: WS10.01 The French Compassionate Programme of elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis with advanced lung disease and no F508del CFTR variant
WS10.01 The French Compassionate Programme of elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis with advanced lung disease and no F508del CFTR variant Open
View article: Chatbot-based serious games: A useful tool for training medical students? A randomized controlled trial
Chatbot-based serious games: A useful tool for training medical students? A randomized controlled trial Open
Objectives Chatbots, conversational agents that walk medical students (MS) though a clinical case, are serious games that seem to be appreciated by MS. Their impact on MS’s performance in exams however was not yet evaluated. Chatprogress i…
View article: CFTR Modulators: Current Status and Evolving Knowledge
CFTR Modulators: Current Status and Evolving Knowledge Open
In the past decade, the medical management of people with cystic fibrosis (pwCF) has changed with the development of small molecules that partially restore the function of the defective CF transmembrane conductance regulator (CFTR) protein…
View article: Neuraminidase is a host‐directed approach to regulate neutrophil responses in sepsis and COVID‐19
Neuraminidase is a host‐directed approach to regulate neutrophil responses in sepsis and COVID‐19 Open
Background and Purpose Neutrophil overstimulation plays a crucial role in tissue damage during severe infections. Because pathogen‐derived neuraminidase (NEU) stimulates neutrophils, we investigated whether host NEU can be targeted to regu…
View article: Acneiform Eruption Following Elexacaftor-Tezacaftor-Ivacaftor Treatment in Patients With Cystic Fibrosis
Acneiform Eruption Following Elexacaftor-Tezacaftor-Ivacaftor Treatment in Patients With Cystic Fibrosis Open
Importance A new treatment for cystic fibrosis combining 3 CFTR modulators—elexacaftor (ELX), tezacaftor (TEZ), and ivacaftor (IVA)—has recently been approved for cystic fibrosis treatment. The cutaneous adverse effects following treatment…
View article: Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis
Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis Open
View article: Cytosolic PCNA interacts with S100A8 and controls an inflammatory subset of neutrophils in COVID-19
Cytosolic PCNA interacts with S100A8 and controls an inflammatory subset of neutrophils in COVID-19 Open
Neutrophils are key players in the hyperinflammatory response upon SARS-CoV-2 infection. We have previously described that cytosolic proliferating cell nuclear antigen (PCNA) controls neutrophil survival and NADPH oxidase-dependent ROS pro…
View article: Études de la fiabilité des réseaux électriques HTA et HTB soumis à des contraintes météorologiques extrêmes vent fort cyclone, canicule, foudre, neige : revue de cas publiés
Études de la fiabilité des réseaux électriques HTA et HTB soumis à des contraintes météorologiques extrêmes vent fort cyclone, canicule, foudre, neige : revue de cas publiés Open
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View article: Specific circulating neutrophils subsets are present in clinically stable adults with cystic fibrosis and are further modulated by pulmonary exacerbations
Specific circulating neutrophils subsets are present in clinically stable adults with cystic fibrosis and are further modulated by pulmonary exacerbations Open
The progressive lung destruction in cystic fibrosis (CF) is tightly associated with chronic bacterial infection and neutrophil-dominated airway inflammation. CF pulmonary disease is complicated by episodes of acute exacerbations, contribut…
View article: Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study
Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study Open
View article: CFTR Modulators in People with Cystic Fibrosis: Real-World Evidence in France
CFTR Modulators in People with Cystic Fibrosis: Real-World Evidence in France Open
Cystic fibrosis (CF) is a rare genetic multisystemic disease, the manifestations of which are due to mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) protein and can lead to respiratory insufficiency and pre…