Clemens Mingels
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View article: Lymphoma Therapy Response Assessment with Low-Dose [<sup>18</sup>F]FDG Total-Body PET/CT
Lymphoma Therapy Response Assessment with Low-Dose [<sup>18</sup>F]FDG Total-Body PET/CT Open
The improved sensitivity of total-body (TB) PET/CT offers the possibility of reducing injected activities. The aim of our study was to define a lower limit of reduced injected activities in [18F]FDG TB PET/CT for interim and end-of-treatme…
View article: Kinetics of the amino acid uptake tracer O-(2-[18F]fluoroethyl)-L-tyrosine (FET) in human brain
Kinetics of the amino acid uptake tracer O-(2-[18F]fluoroethyl)-L-tyrosine (FET) in human brain Open
Compartmental analysis results for [18F]FET uptake in extra-tumoral human brain regions are in accord with the few prior reports, mainly obtained in experimental animals, and support the use of single frame quantitation. Present findings i…
View article: In Vivo Intralesional Positronium Lifetime Imaging of Thyroid Cancer Using Clinically Routine I-124 PET/CT
In Vivo Intralesional Positronium Lifetime Imaging of Thyroid Cancer Using Clinically Routine I-124 PET/CT Open
Purpose Measuring the lifetime of orthopositronium (oPs), the spin triplet of an electron and positron, has emerged as a promising approach for assessing tumor microen-vironment characteristics, leveraging the susceptibility of oPs lifetim…
View article: Diagnostic accuracy in NSCLC lymph node staging with Total-Body and conventional PET/CT
Diagnostic accuracy in NSCLC lymph node staging with Total-Body and conventional PET/CT Open
Introduction Our aim was to characterize the diagnostic accuracy indices for nodal (N)-staging with [ 18 F]FDG Total-Body (TB) and short-axial field-of-view (SAFOV) PET/CT in non-small cell lung cancer (NSCLC) patients referred for staging…
View article: Total Body PET/CT: Future Aspects
Total Body PET/CT: Future Aspects Open
Total-body (TB) positron emission tomography (PET) scanners are classified by their axial field of view (FOV). Long axial field of view (LAFOV) PET scanners can capture images from eyes to thighs in a one-bed position, covering all major o…
View article: In Vivo Positronium Lifetime Measurements with Intravenous Tracer Administration and a Long Axial Field-of-View PET/CT
In Vivo Positronium Lifetime Measurements with Intravenous Tracer Administration and a Long Axial Field-of-View PET/CT Open
Purpose Measuring orthopositronium (oPs) lifetime could in principle provide diagnostic information about the tissue microenvironment that goes beyond standard positron emission tomography (PET) imaging. This study demonstrates that in viv…
View article: Glove Phenomenon Detected by Total-Body PET/CT With 68GA-DOTATATE
Glove Phenomenon Detected by Total-Body PET/CT With 68GA-DOTATATE Open
Accidental intra-arterial injections of radiotracers are rare events resulting in a specific imaging pattern, described as “hot-forearm,” “hot-hand,” “glove-phenomenon,” or “glove-like pattern.” We present a case 68 Ga-DOTATATE total-body …
View article: Total-Body PET/CT: Challenges and Opportunities
Total-Body PET/CT: Challenges and Opportunities Open
Long-axial field-of-view (LAFOV) systems have changed the field of molecular imaging. Since their introduction, many PET centers have installed these next-generation digital systems to provide more detailed imaging and acquire PET images i…
View article: Dose Reduction in Pediatric Oncology Patients with Delayed Total-Body [<sup>18</sup>F]FDG PET/CT
Dose Reduction in Pediatric Oncology Patients with Delayed Total-Body [<sup>18</sup>F]FDG PET/CT Open
Our aim was to define a lower limit of reduced injected activity in delayed [18F]FDG total-body (TB) PET/CT in pediatric oncology patients. Methods: In this single-center prospective study, children were scanned for 20 min with TB PET/CT, …
View article: FDG imaging with long-axial field-of-view PET/CT in patients with high blood glucose—a matched pair analysis
FDG imaging with long-axial field-of-view PET/CT in patients with high blood glucose—a matched pair analysis Open
Purpose High blood glucose (hBG) in patients undergoing [ 18 F]FDG PET/CT scans often results in rescheduling the examination, which may lead to clinical delay for the patient and decrease productivity for the department. The aim of this s…
View article: Long-axial field-of-view PET/CT for the assessment of inflammation in calcified coronary artery plaques with [68 Ga]Ga-DOTA-TOC
Long-axial field-of-view PET/CT for the assessment of inflammation in calcified coronary artery plaques with [68 Ga]Ga-DOTA-TOC Open
Purpose Inflamed, prone-to-rupture coronary plaques are an important cause of myocardial infarction and their early identification is crucial. Atherosclerotic plaques are characterized by overexpression of the type-2 somatostatin receptor …
View article: New thresholds in semi-quantitative [18F]FDG PET/CT are needed to assess large vessel vasculitis with long-axial field-of-view scanners
New thresholds in semi-quantitative [18F]FDG PET/CT are needed to assess large vessel vasculitis with long-axial field-of-view scanners Open
Aim [ 18 F]FDG PET/CT proved accurate in the diagnostic work-up of large vessel vasculitis (LVV). While a visual interpretation is currently considered adequate, several attempts have been made to integrate it with a semiquantitative evalu…
View article: [<sup>177</sup>Lu]Lu-PSMA-617 Therapy in a Patient with Chronic Kidney Disease
[<sup>177</sup>Lu]Lu-PSMA-617 Therapy in a Patient with Chronic Kidney Disease Open
We report the dosimetric evaluation of prostate-specific membrane antigen-based radioligand therapy (RLT) for metastatic prostate cancer in a patient with autosomal-dominant polycystic kidney disease. Methods: The patient received hemodial…
View article: Investigating the influence of long-axial versus short-axial field of view PET/CT on stage migration in lymphoma and non-small cell lung cancer
Investigating the influence of long-axial versus short-axial field of view PET/CT on stage migration in lymphoma and non-small cell lung cancer Open
Objectives The objective of this study was to evaluate the influence of a long-axial field-of-view (LAFOV) on stage migration using a large single-centre retrospective cohort in lymphoma and non-small cell lung cancer (NSCLC). Methods A re…
View article: Long Axial Field-of-View PET/CT Could Answer Unmet Needs in Gynecological Cancers
Long Axial Field-of-View PET/CT Could Answer Unmet Needs in Gynecological Cancers Open
Gynecological malignancies currently affect about 3.5 million women all over the world. Imaging of uterine, cervical, vaginal, ovarian, and vulvar cancer still presents several unmet needs when using conventional modalities such as ultraso…
View article: Long-axial field-of-view PET/CT: perspectives and review of a revolutionary development in nuclear medicine based on clinical experience in over 7000 patients
Long-axial field-of-view PET/CT: perspectives and review of a revolutionary development in nuclear medicine based on clinical experience in over 7000 patients Open
Recently introduced long-axial field-of-view (LAFOV) PET/CT systems represent one of the most significant advancements in nuclear medicine since the advent of multi-modality PET/CT imaging. The higher sensitivity exhibited by such systems …
View article: Impact of the new ultra-high sensitivity mode in a long axial field-of-view PET/CT
Impact of the new ultra-high sensitivity mode in a long axial field-of-view PET/CT Open
Objective Long axial field-of-view (LAFOV) PET/CT showed improved performance resulting from higher sensitivity. The aim was to quantify the impact of using the full acceptance angle (UHS) in image reconstructions with the Biograph Vision …
View article: Feasibility of using abbreviated scans protocols with population-based input functions for accurate kinetic modelling of 18F-FDG datasets from a long-axial FOV PET scanner
Feasibility of using abbreviated scans protocols with population-based input functions for accurate kinetic modelling of 18F-FDG datasets from a long-axial FOV PET scanner Open
Background: Accurate kinetic modelling of 18F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET) data requires accurate knowledge of the available tracer concentration in the plasma during the scan time, known as the arteria…
View article: Quantitative evaluation of a deep learning-based framework to generate whole-body attenuation maps using LSO background radiation in long axial FOV PET scanners
Quantitative evaluation of a deep learning-based framework to generate whole-body attenuation maps using LSO background radiation in long axial FOV PET scanners Open
Purpose Attenuation correction is a critically important step in data correction in positron emission tomography (PET) image formation. The current standard method involves conversion of Hounsfield units from a computed tomography (CT) ima…