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View article: IL-36 signaling as a drug target in Crohn’s disease patients with IL36RN mutations
IL-36 signaling as a drug target in Crohn’s disease patients with IL36RN mutations Open
View article: Limited association between <scp>HRR</scp> gene alterations and <scp>HRD</scp> in molecular tumor board cancer samples: Who should be tested for <scp>HRD</scp>?
Limited association between <span>HRR</span> gene alterations and <span>HRD</span> in molecular tumor board cancer samples: Who should be tested for <span>HRD</span>? Open
Alterations in Homologous Recombination Repair (HRR) Pathway genes have been found to be associated with HR‐Deficiency (HRD), which is an approved biomarker for PARP Inhibitor (PARPi) treatment. The aim of a Molecular Tumor Board (MTB) is …
View article: P048 Identification of IL36RN missense mutations in Crohn’s disease patients as a potentially new drug target for treating rare patients with over-activation of the IL36 signaling cascade
P048 Identification of IL36RN missense mutations in Crohn’s disease patients as a potentially new drug target for treating rare patients with over-activation of the IL36 signaling cascade Open
Background The interleukin 36 (IL-36) family includes the agonists IL-36α, IL-36β, IL-36γ, which activate the NF-κB pathway and the natural antagonist IL-36RA, which inhibits IL-36 signaling. While missense mutations in the gene encoding I…
View article: Determinants Affecting the Clinical Implementation of a Molecularly Informed Molecular Tumor Board Recommendation: Experience from a Tertiary Cancer Center
Determinants Affecting the Clinical Implementation of a Molecularly Informed Molecular Tumor Board Recommendation: Experience from a Tertiary Cancer Center Open
Molecular Tumor Boards (MTBs) converge state-of-the-art next-generation sequencing (NGS) methods with the expertise of an interdisciplinary team consisting of clinicians, pathologists, human geneticists, and molecular biologists to provide…
View article: Novel T cell/organoid culture system allows ex vivo modeling of intestinal graft-versus-host disease
Novel T cell/organoid culture system allows ex vivo modeling of intestinal graft-versus-host disease Open
Acute graft-versus-host disease (GvHD) remains the biggest clinical challenge and prognosis-determining complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Donor T cells are acceptedly key mediators of allore…
View article: Protective effect of the novel calcineurin inhibitor voclosporin in experimental colitis
Protective effect of the novel calcineurin inhibitor voclosporin in experimental colitis Open
Background and aims Acute severe steroid-refractory ulcerative colitis remains a medically challenging condition with frequent need of surgery. It can be treated with the calcineurin inhibitor cyclosporine A with the need for therapeutic d…
View article: Interleukin 36 receptor-inducible matrix metalloproteinase 13 mediates intestinal fibrosis
Interleukin 36 receptor-inducible matrix metalloproteinase 13 mediates intestinal fibrosis Open
Background Fibrostenotic disease is a common complication in Crohn’s disease (CD) patients hallmarked by transmural extracellular matrix (ECM) accumulation in the intestinal wall. The prevention and medical therapy of fibrostenotic CD is a…
View article: P013 Role of IL-36RA mutations in Crohn’s disease
P013 Role of IL-36RA mutations in Crohn’s disease Open
Background The interleukin 36 (IL-36) family consists of three agonists (IL-36α, IL-36β, IL-36γ), that activate the NF-κB pathway and lead to the production of pro-inflammatory cytokines and the natural antagonist (IL-36RA), which inhibits…
View article: Label-Free Characterization and Quantification of Mucosal Inflammation in Common Murine Colitis Models With Multiphoton Imaging
Label-Free Characterization and Quantification of Mucosal Inflammation in Common Murine Colitis Models With Multiphoton Imaging Open
Background Clinical challenges in inflammatory bowel diseases require microscopic in vivo evaluation of inflammation. Here, label-free imaging holds great potential, and recently, our group demonstrated the advantage of using in vivo multi…
View article: In vivo multi spectral colonoscopy in mice
In vivo multi spectral colonoscopy in mice Open
View article: Fallbericht: Persistierendes Fieber nach SARS-CoV-2-Infektion
Fallbericht: Persistierendes Fieber nach SARS-CoV-2-Infektion Open
View article: Targeting STAT3 Signaling in COL1+ Fibroblasts Controls Colitis-Associated Cancer in Mice
Targeting STAT3 Signaling in COL1+ Fibroblasts Controls Colitis-Associated Cancer in Mice Open
Colorectal cancer (CRC) is a common disease and has limited treatment options. The importance of cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) in CRC has been increasingly recognized. However, the role of CAF…
View article: DOP12 Non-invasive assessment of intestinal inflammatory activity in Ulcerative Colitis by Multispectral Optoacoustic Tomography (MSOT)
DOP12 Non-invasive assessment of intestinal inflammatory activity in Ulcerative Colitis by Multispectral Optoacoustic Tomography (MSOT) Open
Background In order to guide therapy in Ulcerative Colitis (UC), repeated determination of intestinal inflammatory activity is essential. Endoscopy is the standard procedure to assess inflammation in UC. However innovative methods for non-…
View article: P075 Neutrophils prevent rectal bleeding in Ulcerative Colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis
P075 Neutrophils prevent rectal bleeding in Ulcerative Colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis Open
Background Bleeding ulcers and erosions are hallmarks of active ulcerative colitis (UC). However, the mechanisms controlling bleeding and mucosal haemostasis remain elusive. Methods We used high resolution endoscopy and colon tissue sample…
View article: Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis
Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis Open
Objective Bleeding ulcers and erosions are hallmarks of active ulcerative colitis (UC). However, the mechanisms controlling bleeding and mucosal haemostasis remain elusive. Design We used high-resolution endoscopy and colon tissue samples …
View article: Dynamic Imaging of IEL-IEC Co-Cultures Allows for Quantification of CD103-Dependent T Cell Migration
Dynamic Imaging of IEL-IEC Co-Cultures Allows for Quantification of CD103-Dependent T Cell Migration Open
Intraepithelial lymphocytes (IEL) are widely distributed within the small intestinal epithelial cell (IEC) layer and represent one of the largest T cell pools of the body. While implicated in the pathogenesis of intestinal inflammation, de…
View article: Th17 Cell-Mediated Colitis Is Positively Regulated by Interferon Regulatory Factor 4 in a T Cell-Extrinsic Manner
Th17 Cell-Mediated Colitis Is Positively Regulated by Interferon Regulatory Factor 4 in a T Cell-Extrinsic Manner Open
Inflammatory bowel diseases (IBDs) are characterized by chronic, inflammatory gastrointestinal lesions and often require life-long treatment with immunosuppressants and repetitive surgical interventions. Despite progress in respect to the …
View article: Primary aortoduodenal fistula – overlooked because of guidelines?
Primary aortoduodenal fistula – overlooked because of guidelines? Open
Primary aortoduodenal fistula is an uncommon yet mostly lethal finding. We present a case of a 63 year-old male who exhibited significant upper gastrointestinal bleeding and hemorrhagic shock. Repeated endoscopies did not detect any source…
View article: ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 and Impact on Respiratory Failure
ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 and Impact on Respiratory Failure Open
Cystic fibrosis patients suffer from a progressive, often fatal lung disease, which is based on a complex interplay between chronic infections, locally accumulating immune cells and pulmonary tissue remodeling. Although group-2 innate lymp…
View article: Retrograde inspection <i>vs</i> standard forward view for the detection of colorectal adenomas during colonoscopy: A back-to-back randomized clinical trial
Retrograde inspection <i>vs</i> standard forward view for the detection of colorectal adenomas during colonoscopy: A back-to-back randomized clinical trial Open
Second inspection of the whole colon leads to increased adenoma detection with no differences between SFV and RFV. Hence, increased detection is most likely a feature of the second inspection itself but not of the inspection mode.
View article: Rationale for IL-36 receptor antibodies in ulcerative colitis
Rationale for IL-36 receptor antibodies in ulcerative colitis Open
Ulcerative colitis (UC) is a chronically relapsing inflammatory disease of the colonic mucosa. It affects genetically susceptible hosts that are influenced by environmental factors and contribution...
View article: Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice
Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice Open
View article: Author Correction: Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation
Author Correction: Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation Open
View article: Cellular Mechanisms of Etrolizumab Treatment in Inflammatory Bowel Disease
Cellular Mechanisms of Etrolizumab Treatment in Inflammatory Bowel Disease Open
Background: Anti-integrin therapy is a new frontline strategy in the treatment of inflammatory bowel diseases (IBD). The anti-β7 integrin antibody etrolizumab is currently being investigated for safety and efficacy in Crohn's diseas…
View article: Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease Open
Gut homing of immune cells is important for the pathogenesis of inflammatory bowel diseases (IBD). Integrin-dependent cell adhesion to addressins is a crucial step in this process and therapeutic strategies interfering with adhesion have b…
View article: OP008 α4β7 Integrin-dependent gut homing of non-classical monocytes is essential for intestinal wound healing mediated by M2 macrophages
OP008 α4β7 Integrin-dependent gut homing of non-classical monocytes is essential for intestinal wound healing mediated by M2 macrophages Open
The anti-α4β7 integrin antibody Vedolizumab is successfully used for the treatment of IBD. Mechanistically, it is well established that it inhibits α4β7 integrin-dependent gut homing of pathogenic T lymphocytes to the inflamed gut. However…
View article: OP038 Hobit- and Blimp1-driven tissue resident memory T cells critically control chronic intestinal inflammation
OP038 Hobit- and Blimp1-driven tissue resident memory T cells critically control chronic intestinal inflammation Open
Tissue resident memory T (TRM) cells expressing CD69 and often co-expressing CD103 reside in peripheral tissues without recirculating. In contrast to the “traditional” central and effector memory T-cell subsets, they form a first-line of a…
View article: Raster-Scanning Optoacoustic Mesoscopy for Gastrointestinal Imaging at High Resolution
Raster-Scanning Optoacoustic Mesoscopy for Gastrointestinal Imaging at High Resolution Open
View article: Good Manufacturing Practice-Compliant Production and Lot-Release of Ex Vivo Expanded Regulatory T Cells As Basis for Treatment of Patients with Autoimmune and Inflammatory Disorders
Good Manufacturing Practice-Compliant Production and Lot-Release of Ex Vivo Expanded Regulatory T Cells As Basis for Treatment of Patients with Autoimmune and Inflammatory Disorders Open
In recent years, the exploration of regulatory T cell (Treg)-based cellular therapy has become an attractive strategy to ameliorate inflammation and autoimmunity in various clinical settings. The main obstacle to the clinical application o…
View article: Three-Dimensional Cross-Sectional Light-Sheet Microscopy Imaging of the Inflamed Mouse Gut
Three-Dimensional Cross-Sectional Light-Sheet Microscopy Imaging of the Inflamed Mouse Gut Open