Clement D. Marshall
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View article: Integrated spatial multiomics reveals fibroblast fate during tissue repair
Integrated spatial multiomics reveals fibroblast fate during tissue repair Open
Significance In the skin, tissue injury results in fibrosis in the form of a scar composed of dense extracellular matrix deposited by fibroblasts. Therapies that promote tissue regeneration rather than fibrosis remain elusive because princ…
View article: Integrated spatial multi-omics reveals fibroblast fate during tissue repair
Integrated spatial multi-omics reveals fibroblast fate during tissue repair Open
In the skin, tissue injury results in fibrosis in the form of scars composed of dense extracellular matrix deposited by fibroblasts. The therapeutic goal of regenerative wound healing has remained elusive in part because principles of fibr…
View article: Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis
Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis Open
Fibroblast heterogeneity has been shown within the unwounded mouse dorsal dermis, with fibroblast subpopulations being identified according to anatomical location and embryonic lineage. Using lineage tracing, we demonstrate that paired rel…
View article: Wound Healing Myofibroblasts Proliferate Clonally and in a Mechanoresponsive Manner
Wound Healing Myofibroblasts Proliferate Clonally and in a Mechanoresponsive Manner Open
INTRODUCTION: Fibroblasts are integral in regulating tissue homeostasis. Notably, activated fibroblasts (myofibroblasts) play critical roles in wound healing including producing and depositing extracellular matrix and driving wound closure…
View article: Elucidating the fundamental fibrotic processes driving abdominal adhesion formation
Elucidating the fundamental fibrotic processes driving abdominal adhesion formation Open
View article: Abstract 190: Dermal Wounding Reveals Focal Adhesion Kinase Dependent Tissue-Resident Fibroblast Progenitors
Abstract 190: Dermal Wounding Reveals Focal Adhesion Kinase Dependent Tissue-Resident Fibroblast Progenitors Open
Purpose: Wound healing is a complex process that involves the extensive coordination of different cell types, most significant of which is the fibroblast. Fibroblasts play a key role in wound healing by assisting in wound closure and tissu…
View article: Abstract 2: Epigenetic Modulation of TGF-beta Signaling Underlies the Scarring Fibroblast Phenotype
Abstract 2: Epigenetic Modulation of TGF-beta Signaling Underlies the Scarring Fibroblast Phenotype Open
PURPOSE: Scars represent a massive clinical and financial burden on healthcare systems. Interestingly, mammalian fetuses are capable of scarless wound healing. However, little progress has been made toward scarless healing in adult patient…
View article: Wounds Inhibit Tumor Growth In Vivo
Wounds Inhibit Tumor Growth In Vivo Open
Objective: The aim of this study was to determine the interaction of full thickness excisional wounds and tumors in vivo. Summary of Background Data: Tumors have been described as wounds that do not heal due to similarities in stromal comp…
View article: Doxycycline Reduces Scar Thickness and Improves Collagen Architecture
Doxycycline Reduces Scar Thickness and Improves Collagen Architecture Open
Objective: To investigate the effects of local doxycycline administration on skin scarring. Background: Skin scarring represents a major source of morbidity for surgical patients. Doxycycline, a tetracycline antibiotic with off-target effe…
View article: In Vitro and In Vivo Osteogenic Differentiation of Human Adipose-Derived Stromal Cells
In Vitro and In Vivo Osteogenic Differentiation of Human Adipose-Derived Stromal Cells Open
View article: Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration
Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration Open
View article: Author Correction: Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes
Author Correction: Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes Open
In the original version of this Article, the authors inadvertently omitted Elizabeth A. Brett, who contributed to the generation of the histology figures, from the author list.This has now been corrected in both the PDF and HTML versions o…
View article: Implementing a Standardized Nurse-driven Rounding Protocol in a Trauma-surgical Intensive Care Unit: A Single Institution Experience
Implementing a Standardized Nurse-driven Rounding Protocol in a Trauma-surgical Intensive Care Unit: A Single Institution Experience Open
View article: Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes
Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes Open
View article: Abstract 43: Embryonic Expression of Prrx1 Identifies the Fibroblast Responsible for Scarring in the Mouse Ventral Dermis
Abstract 43: Embryonic Expression of Prrx1 Identifies the Fibroblast Responsible for Scarring in the Mouse Ventral Dermis Open
PURPOSE: Scarring and fibrosis are tremendous public health concerns, leading to excessive morbidity and mortality, in addition to countless healthcare dollars. Although there are many treatments for cutaneous scarring available, few have …
View article: Stem Cell Regeneration and Repair – Overview
Stem Cell Regeneration and Repair – Overview Open
Mammalian skin holds a remarkable capacity to regenerate and repair itself in the face of continuous environmental exposures as well as frequent injuries. During normal skin homeostasis, a complex group of skin stem cells of different orig…
View article: Delivery of monocyte lineage cells in a biomimetic scaffold enhances tissue repair
Delivery of monocyte lineage cells in a biomimetic scaffold enhances tissue repair Open
The monocyte lineage is essential to normal wound healing. Macrophage inhibition or knockout in mice results in impaired wound healing through reduced neovascularization, granulation tissue formation, and reepithelialization. Numerous stud…
View article: Abstract 127: A Mouse Model of Mandibular Distraction Osteogenesis
Abstract 127: A Mouse Model of Mandibular Distraction Osteogenesis Open
PURPOSE: Distraction osteogenesis (DO) is a powerful method of endogenous bone tissue engineering that has been applied to the craniofacial skeleton with great success. However, the cellular and molecular signaling that governs this proces…
View article: Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model
Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model Open
Invasive cancers, major injuries, and infection can cause bone defects that are too large to be reconstructed with preexisting bone from the patient's own body. The ability to grow bone de novo using a patient's own cells would allow bony …
View article: Mechanical Forces in Cutaneous Wound Healing: Emerging Therapies to Minimize Scar Formation
Mechanical Forces in Cutaneous Wound Healing: Emerging Therapies to Minimize Scar Formation Open
Significance: Excessive scarring is major clinical and financial burden in the United States. Improved therapies are necessary to reduce scarring, especially in patients affected by hypertrophic and keloid scars. Recent Advances:…
View article: Abstract: ATAC-seq Reveals Heterogeneity of Fibroblasts During Transition from Scarless Fetal to Scar-Forming Adult Wound Repair
Abstract: ATAC-seq Reveals Heterogeneity of Fibroblasts During Transition from Scarless Fetal to Scar-Forming Adult Wound Repair Open
INTRODUCTION: Cutaneous wounds in early gestation heal without a scar in a process resembling regeneration.1 Although myriad studies have been performed to understand this phenomenon, the exact mechanism for fetal scarless repair is unknow…
View article: Abstract: Generation of a Novel Scaffold for In Vivo Polarization of Therapeutic Macrophages and Delivery of IL 10 to Improve Cutaneous Wound Healing
Abstract: Generation of a Novel Scaffold for In Vivo Polarization of Therapeutic Macrophages and Delivery of IL 10 to Improve Cutaneous Wound Healing Open
INTRODUCTION: Defective cutaneous wound healing poses a significant clinical challenge, so it is necessary to develop novel techniques to improve tissue regeneration and repair. Macrophages are critical for effective wound repair, as their…
View article: Creation of Abdominal Adhesions in Mice
Creation of Abdominal Adhesions in Mice Open
Abdominal adhesions consist of fibrotic tissue that forms in the peritoneal space in response to an inflammatory insult, typically surgery or intraabdominal infection. The precise mechanisms underlying adhesion formation are poorly underst…
View article: Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions
Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions Open
Significance: Scarring of the skin from burns, surgery, and injury constitutes a major burden on the healthcare system. Patients affected by major scars, particularly children, suffer from long-term functional and psychological prob…
View article: Scarless wound healing: finding the right cells and signals
Scarless wound healing: finding the right cells and signals Open
View article: Mesenchymal Stromal Cells as Cell‐Based Therapeutics for Wound Healing
Mesenchymal Stromal Cells as Cell‐Based Therapeutics for Wound Healing Open
Chronic wounds are a source of substantial morbidity for patients and are a major financial burden for the healthcare system. There are no current therapies that reliably improve nonhealing wounds or reverse pathological scarring. Mesenchy…