Clément Ghiazza
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View article: Synthesis of unique 1,2-diazepine-fused b-lactams via Staudinger-type [2+2] cyclization
Synthesis of unique 1,2-diazepine-fused b-lactams via Staudinger-type [2+2] cyclization Open
Herein, we report a one-pot sequence to prepare 1,2-diazepine fused b-lactams under photochemical irradiation. Hence, a-diazoketones are readily converted to corresponding ketenes in an additive-free Wolff rearrangement. The operative mech…
View article: Improving the Photochemical Skeletal Enlargement of Pyridines to 1,2‐Diazepines with Isocyanates
Improving the Photochemical Skeletal Enlargement of Pyridines to 1,2‐Diazepines with Isocyanates Open
In this work, we extend the one‐pot protocol to synthesize 1,2‐diazepines from commercially available and cheap starting materials. Capitalizing on isocyanate derivatives as activating agents, the photochemical skeletal enlargement occurs,…
View article: Atroposelective Construction of Axially Chiral 2-Aryl-Pyrroloquinolones
Atroposelective Construction of Axially Chiral 2-Aryl-Pyrroloquinolones Open
A two-step protocol including an enantioselective organocatalyzed synthesis of pyrroloquinolines followed by an oxidation reaction allowed the formation of axially chiral 2-aryl-pyrroloquinolones. Thorough optimization of the experimental …
View article: Modern Dearomative Enlargement of Heteroaromatic Rings
Modern Dearomative Enlargement of Heteroaromatic Rings Open
Breaking aromaticity by inserting additional atoms within the skeleton of heteroaromatic rings has gained significant attention over the years. As part of the emerging concept of ‘skeletal editing’, this short review retraces the recent pr…
View article: CCDC 2279847: Experimental Crystal Structure Determination
CCDC 2279847: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2279846: Experimental Crystal Structure Determination
CCDC 2279846: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2279850: Experimental Crystal Structure Determination
CCDC 2279850: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2279849: Experimental Crystal Structure Determination
CCDC 2279849: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2279848: Experimental Crystal Structure Determination
CCDC 2279848: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Dearomatization of Pyridines: Photochemical Skeletal Enlargement for the Synthesis of 1,2-Diazepines
Dearomatization of Pyridines: Photochemical Skeletal Enlargement for the Synthesis of 1,2-Diazepines Open
In this report, we developed a unified and standardized one-pot sequence that converts pyridine derivatives into 1,2-diazepines by inserting a nitrogen atom. This skeletal transformation capitalizes on the in situ generation of 1-aminopyri…
View article: CCDC 2195539: Experimental Crystal Structure Determination
CCDC 2195539: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2195782: Experimental Crystal Structure Determination
CCDC 2195782: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2191469: Experimental Crystal Structure Determination
CCDC 2191469: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2191470: Experimental Crystal Structure Determination
CCDC 2191470: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2191466: Experimental Crystal Structure Determination
CCDC 2191466: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2195786: Experimental Crystal Structure Determination
CCDC 2195786: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2191468: Experimental Crystal Structure Determination
CCDC 2191468: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2191471: Experimental Crystal Structure Determination
CCDC 2191471: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2195783: Experimental Crystal Structure Determination
CCDC 2195783: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2195540: Experimental Crystal Structure Determination
CCDC 2195540: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2195541: Experimental Crystal Structure Determination
CCDC 2195541: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2195784: Experimental Crystal Structure Determination
CCDC 2195784: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2195785: Experimental Crystal Structure Determination
CCDC 2195785: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2191467: Experimental Crystal Structure Determination
CCDC 2191467: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2195538: Experimental Crystal Structure Determination
CCDC 2195538: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Bio‐Inspired Deaminative Hydroxylation of Aminoheterocycles and Electron‐Deficient Anilines
Bio‐Inspired Deaminative Hydroxylation of Aminoheterocycles and Electron‐Deficient Anilines Open
Among the tools available to chemists for drug design of bioactive compounds, the bioisosteric replacement of atoms or groups of atoms is the cornerstone of modern strategies. Despite the undeniable interest in amino‐to‐hydroxyl interchang…
View article: Bio‐Inspired Deaminative Hydroxylation of Aminoheterocycles and Electron‐Deficient Anilines
Bio‐Inspired Deaminative Hydroxylation of Aminoheterocycles and Electron‐Deficient Anilines Open
Among the tools available to chemists for drug design of bioactive compounds, the bioisosteric replacement of atoms or groups of atoms is the cornerstone of modern strategies. Despite the undeniable interest in amino‐to‐hydroxyl interchang…
View article: Strain‐Release Pentafluorosulfanylation and Tetrafluoro(aryl)sulfanylation of [1.1.1]Propellane: Reactivity and Structural Insight**
Strain‐Release Pentafluorosulfanylation and Tetrafluoro(aryl)sulfanylation of [1.1.1]Propellane: Reactivity and Structural Insight** Open
We leveraged the recent increase in synthetic accessibility of SF 5 Cl and Ar−SF 4 Cl compounds to combine chemistry of the SF 5 and SF 4 Ar groups with strain‐release functionalization. By effectively adding SF 5 and SF 4 Ar radicals acro…
View article: Strain‐Release Pentafluorosulfanylation and Tetrafluoro(aryl)sulfanylation of [1.1.1]Propellane: Reactivity and Structural Insight**
Strain‐Release Pentafluorosulfanylation and Tetrafluoro(aryl)sulfanylation of [1.1.1]Propellane: Reactivity and Structural Insight** Open
We leveraged the recent increase in synthetic accessibility of SF 5 Cl and Ar−SF 4 Cl compounds to combine chemistry of the SF 5 and SF 4 Ar groups with strain‐release functionalization. By effectively adding SF 5 and SF 4 Ar radicals acro…
View article: Strain-release Pentafluorosulfanylation and Tetrafluoro(aryl)sulfanylation of [1.1.1]Propellane: Reactivity and Structural Insight
Strain-release Pentafluorosulfanylation and Tetrafluoro(aryl)sulfanylation of [1.1.1]Propellane: Reactivity and Structural Insight Open
We leveraged the recent increase in synthetic accessibility of SF5Cl and Ar-SF4Cl compounds to combine chemistry of the SF5 and SF4Ar groups with strain-release functionalization. By effectively adding SF5 and SF4Ar radicals across [1.1.1]…