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View article: Correction: Epigenetic scores for the circulating proteome as tools for disease prediction
Correction: Epigenetic scores for the circulating proteome as tools for disease prediction Open
View article: Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes
Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes Open
View article: TeenCovidLife: a resource to understand the impact of the COVID-19 pandemic on adolescents in Scotland
TeenCovidLife: a resource to understand the impact of the COVID-19 pandemic on adolescents in Scotland Open
TeenCovidLife is part of Generation Scotland’s CovidLife projects, a set of longitudinal observational studies designed to assess the psychosocial and health impacts of the COVID-19 pandemic. TeenCovidLife focused on how adolescents in Sco…
View article: RuralCovidLife: A new resource for the impact of the pandemic on rural Scotland.
RuralCovidLife: A new resource for the impact of the pandemic on rural Scotland. Open
RuralCovidLife is part of Generation Scotland’s CovidLife project, investigating the impact of the COVID-19 pandemic and mitigation measures on people in Scotland. The RuralCovidLife project focuses on Scotland’s rural communities, and how…
View article: Blood-based epigenome-wide analyses of cognitive abilities
Blood-based epigenome-wide analyses of cognitive abilities Open
Background Blood-based markers of cognitive functioning might provide an accessible way to track neurodegeneration years prior to clinical manifestation of cognitive impairment and dementia. Results Using blood-based epigenome-wide analyse…
View article: Epigenetic scores for the circulating proteome as tools for disease prediction
Epigenetic scores for the circulating proteome as tools for disease prediction Open
Protein biomarkers have been identified across many age-related morbidities. However, characterising epigenetic influences could further inform disease predictions. Here, we leverage epigenome-wide data to study links between the DNA methy…
View article: Blood-based epigenome-wide analyses of cognitive abilities
Blood-based epigenome-wide analyses of cognitive abilities Open
CpGs and corresponding mean weights for DNAm-based prediction of cognitive abilities (6 traits)
View article: Blood-based epigenome-wide analyses of cognitive abilities
Blood-based epigenome-wide analyses of cognitive abilities Open
CpGs and corresponding mean weights for DNAm-based prediction of cognitive abilities (6 traits)
View article: Author response: Epigenetic scores for the circulating proteome as tools for disease prediction
Author response: Epigenetic scores for the circulating proteome as tools for disease prediction Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Protein b…
View article: RuralCovidLife: Study protocol and description of the data
RuralCovidLife: Study protocol and description of the data Open
RuralCovidLife is part of Generation Scotland’s CovidLife project, investigating the impact of the COVID-19 pandemic and mitigation measures on people in Scotland. The RuralCovidLife project focuses on Scotland’s rural communities, and how…
View article: Development and validation of DNA Methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes
Development and validation of DNA Methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes Open
Type 2 diabetes mellitus (T2D) presents a major health and economic burden that could be alleviated with improved early prediction and intervention. While standard risk factors have shown good predictive performance, we show that the use o…
View article: TeenCovidLife: a resource to understand the impact of the COVID-19 pandemic on adolescents in Scotland
TeenCovidLife: a resource to understand the impact of the COVID-19 pandemic on adolescents in Scotland Open
TeenCovidLife is part of Generation Scotland’s CovidLife projects, a set of longitudinal observational studies designed to assess the psychosocial and health impacts of the COVID-19 pandemic. TeenCovidLife focused on how adolescents in Sco…
View article: CovidLife: a resource to understand mental health, well-being and behaviour during the COVID-19 pandemic in the UK
CovidLife: a resource to understand mental health, well-being and behaviour during the COVID-19 pandemic in the UK Open
CovidLife is a longitudinal observational study designed to investigate the impact of the COVID-19 pandemic on mental health, well-being and behaviour in adults living in the UK. In total, 18,518 participants (mean age = 56.43, SD = 14.35)…
View article: Socioeconomic position and mental health during the COVID-19 pandemic: a cross-sectional analysis of the CovidLife study
Socioeconomic position and mental health during the COVID-19 pandemic: a cross-sectional analysis of the CovidLife study Open
Background: The coronavirus disease 2019 (COVID-19) pandemic has been linked to an increase in mental health problems. This study examined their association with socioeconomic position (SEP), as well as potential confounding and mediating …
View article: Blood-based epigenome-wide analyses of cognitive abilities
Blood-based epigenome-wide analyses of cognitive abilities Open
Using blood-based epigenome-wide analyses of general cognitive function ( g ; n=9,162) we show that individual differences in DNA methylation (DNAm) explain 35.0% of the variance in g . A DNAm predictor explains ∼4% of the variance in g , …
View article: Face covering adherence is positively associated with better mental health and wellbeing: a longitudinal analysis of the CovidLife surveys
Face covering adherence is positively associated with better mental health and wellbeing: a longitudinal analysis of the CovidLife surveys Open
Background: Face masks or coverings are effective at reducing airborne infection rates, yet pandemic mitigation measures, including wearing face coverings, have been suggested to contribute to reductions in quality of life and poorer ment…
View article: Face covering adherence is positively associated with better mental health and wellbeing: a longitudinal analysis of the CovidLife surveys
Face covering adherence is positively associated with better mental health and wellbeing: a longitudinal analysis of the CovidLife surveys Open
Face masks or coverings are effective at reducing airborne infection rates, yet pandemic mitigation measures, including wearing face coverings, have been suggested to contribute to reductions in quality of life and poorer mental health. Lo…
View article: Epigenetic scores for the circulating proteome as tools for disease prediction
Epigenetic scores for the circulating proteome as tools for disease prediction Open
Protein biomarkers have been identified across many age-related morbidities. However, characterising epigenetic influences could further inform disease predictions. Here, we leverage epigenome-wide data to study links between the DNAm sign…
View article: Use of text-mining methods to improve efficiency in the calculation of drug exposure to support pharmacoepidemiology studies
Use of text-mining methods to improve efficiency in the calculation of drug exposure to support pharmacoepidemiology studies Open
We created an NLP algorithm, operational at scale, to produce structured output that gives data users maximum flexibility to formulate, test and apply their own assumptions according to the medicines under investigation. Text mining approa…
View article: Application of natural language processing methods to extract coded data from administrative data held in the Scottish Prescribing Information System
Application of natural language processing methods to extract coded data from administrative data held in the Scottish Prescribing Information System Open
ObjectivesThe Prescribing Information System (PIS) datamart, hosted by NHS National Services Scotland receives around 90 million electronic prescription messages per year from GP practices across Scotland. Prescription messages contain inf…
View article: Data Resource Profile: The Scottish National Prescribing Information System (PIS)
Data Resource Profile: The Scottish National Prescribing Information System (PIS) Open
Data Resource Basics: The Prescribing Information System (PIS) covers the prescribed,dispensed and reimbursed prescriptions in community pharmacies from the 5.3 million residents in Scotland. Summary information is available from 1993 and …