Abstract Background Mandibular osteoradionecrosis (ORN) is a severe late complication affecting patients with head and neck cancer (HNC) treated with radiotherapy that significantly impacts patients’ quality of life and can require costly interventions. While radiation dose is a key factor, other clinical and demographic risk factors influence ORN development. Previous predictive models have primarily been single-institutional, limiting their generalizability. The PREDMORN Consortium was established to address the…

Abstract Background Pathologic extranodal extension (pENE) is a crucial prognostic factor in oropharyngeal cancer (OPC), but determining pENE from imaging has high inter‐observer variability. The role of clinician specialty in the accuracy of imaging‐detected extranodal extension (iENE) remains unclear. The purpose of this study is to assess the influence of clinician specialty on the accuracy of preoperative iENE detection in human papillomavirus (HPV)‐positive OPC using computed tomography (CT) imaging. Methods …

Abstract In a phase II trial, patients with local-regionally advanced human papillomavirus–positive oropharyngeal carcinoma (n = 35) received ipilimumab (anti-CTLA4) and nivolumab (anti–PD-1) as induction immunotherapy and concurrently with radiotherapy (NCT03799445). Coprimary endpoints included 6-month complete metabolic response rate (94%) and 2-year progression-free survival (84%). Induction yielded a 46% major histopathologic response rate. Single-cell profiling revealed responders had higher baseline intratu…

Abstract Objective The purpose of this study was to optimize the technical tradeoffs associated with integrating the quantitative maps available from SyntheticMR into the head and neck adaptive radiation oncology workflow. Recent work has begun to investigate SyntheticMR in the adaptive radiation oncology workflow, however no studies have investigated the variation in acquisition parameters and their relationship to the resulting quantitative maps. Filling this gap will facilitate SyntheticMR’s translation to the …

Abstract Objective Osteoradionecrosis of the jaw (ORNJ) is a chronic radiation-associated toxicity that lacks standardized classification criteria and treatment guidelines. Understanding early signs of tissue injury could help us better predict, prevent, and conservatively manage ORN. Our primary aims were to identify initial clinically-detected signs of ORN, determine the frequency of imaging-detected ORNJ, and validate the ability to classify cases using the novel system, ClinRad. Study Design A retrospective el…