Clint E. Kinney
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View article: MON-670 Pituitary Expression of Brain-Derived Neurotrophic Factor (BDNF) and Projection of Hypothalamic BDNF-expressing Neurons
MON-670 Pituitary Expression of Brain-Derived Neurotrophic Factor (BDNF) and Projection of Hypothalamic BDNF-expressing Neurons Open
Disclosure: E.C. Tsao: None. A.F. Zhao: None. J.C. Han: None. C.E. Kinney: None. Objectives: Brain-derived neurotrophic factor (BDNF) plays important roles in embryologic development of the central nervous system and postnatally functions …
View article: Energy expenditure deficits drive obesity in a mouse model of Alström syndrome
Energy expenditure deficits drive obesity in a mouse model of Alström syndrome Open
Alström syndrome (AS) is a rare multi-system disorder for which early-onset childhood obesity is a cardinal feature. Like humans with AS, animal models with Alms1 loss-of-function mutations develop obesity, supporting the notion that ALMS1…
View article: TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits
TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits Open
View article: TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits
TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits Open
The TrkB receptor is critical for the control of energy balance, as mutations in its gene ( NTRK2 ) lead to hyperphagia and severe obesity in humans and mice. The main neural substrate mediating the appetite-suppressing activity of TrkB, h…
View article: TrkB-expressing neurons in the dorsomedial hypothalamus are necessary and sufficient to suppress homeostatic feeding
TrkB-expressing neurons in the dorsomedial hypothalamus are necessary and sufficient to suppress homeostatic feeding Open
Significance The dorsomedial hypothalamus (DMH) is well known for its role in the regulation of energy expenditure; however, its role in the control of appetite is less defined. Our study identifies TrkB-expressing DMH neurons that potentl…
View article: Disruption of brain-derived neurotrophic factor production from individual promoters generates distinct body composition phenotypes in mice
Disruption of brain-derived neurotrophic factor production from individual promoters generates distinct body composition phenotypes in mice Open
Brain-derived neurotrophic factor (BDNF) is a key neuropeptide in the central regulation of energy balance. The Bdnf gene contains nine promoters, each producing specific mRNA transcripts that encode a common protein. We sought to assess t…
View article: Discrete BDNF Neurons in the Paraventricular Hypothalamus Control Feeding and Energy Expenditure
Discrete BDNF Neurons in the Paraventricular Hypothalamus Control Feeding and Energy Expenditure Open