Clive Holmes
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View article: Periodontitis and incident cognitive decline and dementia: A 15-year prospective cohort study of older men residing in Northern Ireland
Periodontitis and incident cognitive decline and dementia: A 15-year prospective cohort study of older men residing in Northern Ireland Open
Background Periodontitis is a chronic bacterial infection that elicits systemic inflammation. While retrospective studies have linked periodontal pathogens with Alzheimer's disease (AD) and dementia, few have combined cognitive assessments…
View article: Liraglutide in mild to moderate Alzheimer’s disease: a phase 2b clinical trial
Liraglutide in mild to moderate Alzheimer’s disease: a phase 2b clinical trial Open
Liraglutide, a glucagon-like peptide 1 (GLP-1) agonist and antidiabetic drug, has shown neuroprotective effects in animal models. In this study, we aimed to evaluate the safety and efficacy of liraglutide in mild to moderate Alzheimer’s di…
View article: A National Evaluation of Intercostal Chest Drain Removal Strategies
A National Evaluation of Intercostal Chest Drain Removal Strategies Open
Our results indicate that recurrent pneumothorax after ICD removal is a common complication of admission. Clamping trials are safe but do not appear to be associated with reduced rates of recurrent pneumothorax. An ultracautious approach u…
View article: Low Hand Grip Strength Is Associated with Increased Risk of Cognitive Impairment in Older Men, Including Men with Probable Sarcopenic Obesity: Results from the Northern Ireland PRIME-COG Cohort
Low Hand Grip Strength Is Associated with Increased Risk of Cognitive Impairment in Older Men, Including Men with Probable Sarcopenic Obesity: Results from the Northern Ireland PRIME-COG Cohort Open
Introduction: The relationship between cognitive impairment and a phenotype comprising low muscle strength coupled with excess adiposity, representative of sarcopenic obesity, is not well defined. The present study aimed to elucidate the r…
View article: Do glial‐reactivity and cerebral blood flow modulate cerebral glucose metabolism in Alzheimer’s disease?
Do glial‐reactivity and cerebral blood flow modulate cerebral glucose metabolism in Alzheimer’s disease? Open
Background Alzheimer’s disease is a devastating neurodegenerative disorder with a complex pathogenesis. One main pathological feature utilised in diagnosis is neurodegeneration or neuronal injury, which is reflected in reductions in cerebr…
View article: Increased levels of Matrix Metaloproteinase‐10 and Adenosine Deaminase in blood are associated with reduced cognition
Increased levels of Matrix Metaloproteinase‐10 and Adenosine Deaminase in blood are associated with reduced cognition Open
Background Neuroinflammation and activation of the immune system can influence Alzheimer’s disease (AD) progression. This is mediated by inflammatory molecules, which exacerbate the production of β‐amyloid, the propagation of tau pathology…
View article: Extremely rare CNVs contributing to Alzheimer disease risk: a case-control association analysis of exome sequencing data from 22,319 individuals
Extremely rare CNVs contributing to Alzheimer disease risk: a case-control association analysis of exome sequencing data from 22,319 individuals Open
Rare coding single nucleotide variants (SNV) and short insertions or deletions (indels) contribute to Alzheimer disease (AD) genetic risk, from pathogenic variants in autosomal dominant genes to risk factors with diverse effects. In contra…
View article: Changes in the locus coeruleus during the course of Alzheimer's disease and their relationship to cortical pathology
Changes in the locus coeruleus during the course of Alzheimer's disease and their relationship to cortical pathology Open
Aims In Alzheimer's disease (AD), the locus coeruleus (LC) undergoes early and extensive neuronal loss, preceded by abnormal intracellular tau aggregation, decades before the onset of clinical disease. Neuromelanin‐sensitive MRI has been p…
View article: MRI CHANGES FOLLOWING TREATMENT OF GLP‐1 ANALOGUE, LIRAGLUTIDE IN ALZHEIMER’S DISEASE
MRI CHANGES FOLLOWING TREATMENT OF GLP‐1 ANALOGUE, LIRAGLUTIDE IN ALZHEIMER’S DISEASE Open
Background Preclinical evidence in transgenic models of Alzheimer’s disease (AD) suggests that liraglutide, a GLP1 analogue, exerts neuroprotective effects by reducing amyloid oligomers, normalising synaptic plasticity and reducing insulin…
View article: Periodontitis and future cognitive decline
Periodontitis and future cognitive decline Open
Background Periodontitis (gum disease) is a is a chronic inflammatory disorder. Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), Aggregatibacter actinomyecetemcomitans (Aa), and Treponema denticola (Td) are the most common periodo…
View article: Magnetic Resonance Spectroscopy metabolites as biomarkers of Alzheimer’s Disease
Magnetic Resonance Spectroscopy metabolites as biomarkers of Alzheimer’s Disease Open
Background Magnetic resonance spectroscopy (MRS) is a non‐invasive method of evaluating metabolite levels in the cerebral cortex. Measurable metabolites can provide markers of neuronal damage, glial activation and, neurotransmission, patho…
View article: Dysfunctional cerebral glucose transport in Alzheimer’s Disease
Dysfunctional cerebral glucose transport in Alzheimer’s Disease Open
Background Glucose is the primary energy source required for the homeostatic function of the brain. Glucose transporter 1 (GLUT1) present at the blood‐brain barrier is a key regulator of glucose transport into the brain. Reduced GLUT1 expr…
View article: Lower serum carotenoid levels are associated with incident cognitive decline independent of traditional risk factors in a prospective study of older men from Northern Ireland
Lower serum carotenoid levels are associated with incident cognitive decline independent of traditional risk factors in a prospective study of older men from Northern Ireland Open
Background Nutritional influences, and antioxidant status in particular, have been implicated in the aetiology of cognitive decline. This study investigated the neuroprotective effects of serum antioxidants in a prospective cohort of older…
View article: Hand grip strength, anthropometrics and cognitive decline
Hand grip strength, anthropometrics and cognitive decline Open
Background Hand grip strength is a well validated measure of physical strength, while anthropometric measures such as weight, waist, hip and mid upper arm circumference, are well validated to determine physical health. The present analysis…
View article: The RESIST Study: Do TNF Inhibitors Protect Against Cognitive Decline in Rheumatoid Arthritis Patients With Mild Cognitive Impairment?
The RESIST Study: Do TNF Inhibitors Protect Against Cognitive Decline in Rheumatoid Arthritis Patients With Mild Cognitive Impairment? Open
Background Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic inflammation in the joint synovium. Considering growing research interest into the role that systemic inflammation might play in the pathogenesis of Alz…
View article: 147 PRIME-COG study: grip strength, anthropometrics and cognitive decline
147 PRIME-COG study: grip strength, anthropometrics and cognitive decline Open
Background Measurement of hand grip strength is a validated measure of physical strength. While anthropometric measurements including waist, hip and mid-upper-arm circumference, are validated for physical health. Evidence has suggested gri…
View article: Domain mapping of disease mutations supports genetic testing of specific<i>SORL1</i>variants in familial Alzheimer’s Disease
Domain mapping of disease mutations supports genetic testing of specific<i>SORL1</i>variants in familial Alzheimer’s Disease Open
Background Protein truncating variants (PTVs) in SORL1 are observed almost exclusively in Alzheimer’s Disease (AD) cases, but the effect of rare SORL1 missense variants is unclear. Methods To identify high-priority missense variants (HPVs)…
View article: Measuring the Permeability of the Blood-Brain Barrier in Alzheimer's Disease Using Dynamic Contrast Enhanced MRI
Measuring the Permeability of the Blood-Brain Barrier in Alzheimer's Disease Using Dynamic Contrast Enhanced MRI Open
Aims 1) To compare blood brain barrier (BBB) permeability between AD and controls. 2) To examine the relationship between BBB permeability and cognitive decline in AD. 3) To examine the relationship between BBB permeability and peripheral …
View article: The effect of the tumour necrosis factor-alpha-inhibitor etanercept on microglial activation patients with mild cognitive impairment—a PET study
The effect of the tumour necrosis factor-alpha-inhibitor etanercept on microglial activation patients with mild cognitive impairment—a PET study Open
Aim: Microglial activation is increasingly recognised as a factor in the progression of Alzheimer’s disease (AD) and may be modified by systemic inflammatory signals including serum tumour necrosis factor (TNF)-α. The aim was to investigat…
View article: Capillary angiopathy and aquaporin-4 after Aβ immunisation in Alzheimer’s disease – potential relevance to Amyloid-Related Imaging Abnormalities
Capillary angiopathy and aquaporin-4 after Aβ immunisation in Alzheimer’s disease – potential relevance to Amyloid-Related Imaging Abnormalities Open
Aims Amyloid-related imaging abnormalities (ARIA) have hampered clinical trials and therapeutic use of amyloid-β (Aβ) immunotherapy for Alzheimer’s disease (AD), with the cause of the white matter oedema (ARIA-E) unknown. Aquaporin 4 (AQP4…
View article: Summary statistics for "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's Disease"
Summary statistics for "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's Disease" Open
These are the burden test results (summary statistics) for the publication: "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s Disease", Nature Genetics, 2022. Format: tab-separated-valu…
View article: Summary statistics for "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's Disease"
Summary statistics for "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's Disease" Open
These are the burden test results (summary statistics) for the publication: "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s Disease", Nature Genetics, 2022. Format: tab-separated-valu…