Clive J. Roberts
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View article: Investigation of Biodegradable and Non-Biodegradable Solvents for the Fabrication of Polylactic Acid Membranes via Nonsolvent Induced Phase Separation (NIPS) for Air Filtration Applications
Investigation of Biodegradable and Non-Biodegradable Solvents for the Fabrication of Polylactic Acid Membranes via Nonsolvent Induced Phase Separation (NIPS) for Air Filtration Applications Open
The substitution of hazardous, environmentally persistent solvents (NMP and DMAc) with more sustainable alternatives (ETAc and GBL) in fabricating flat sheet polyactic acid (PLA) membranes via nonsolvent-induced phase separation for air fi…
View article: Development of an efficient approach to boost fused deposition modeling (FDM) printing of felodipine-HPMC tablets for enhanced physical stability
Development of an efficient approach to boost fused deposition modeling (FDM) printing of felodipine-HPMC tablets for enhanced physical stability Open
Fused deposition modeling (FDM) is a widely investigated 3D printing technology for pharmaceutical applications because of its advantages, including easy access of equipment and cost-effectiveness. Despite its versatility, the FDM 3D print…
View article: High-Throughput Microarray Approaches for Predicting the Stability of Drug–Polymer Solid Dispersions
High-Throughput Microarray Approaches for Predicting the Stability of Drug–Polymer Solid Dispersions Open
Amorphous solid dispersions (ASDs) offer a well-recognized strategy to improve the effective solubility and, hence, bioavailability of poorly soluble drugs. In this study, we developed an extensive library of a significant number of solid …
View article: Enabling high-fidelity personalised pharmaceutical tablets through multimaterial inkjet 3D printing with a water-soluble excipient
Enabling high-fidelity personalised pharmaceutical tablets through multimaterial inkjet 3D printing with a water-soluble excipient Open
View article: Controlled release of MT-1207 using a novel gastroretentive bilayer system comprised of hydrophilic and hydrophobic polymers
Controlled release of MT-1207 using a novel gastroretentive bilayer system comprised of hydrophilic and hydrophobic polymers Open
In the present study, novel gastroretentive bilayer tablets were developed that are promising for the once-a-day oral delivery of the drug candidate MT-1207. The gastroretentive layer consisted of a combination of hydrophilic and hydrophob…
View article: Outstanding Hardening Effect of High-Temperature Aging of Alloy Ti-6al-4v Composite Reinforced with Tic
Outstanding Hardening Effect of High-Temperature Aging of Alloy Ti-6al-4v Composite Reinforced with Tic Open
View article: Utilising micron scale 3D printed morphologies for particle adhesion reduction
Utilising micron scale 3D printed morphologies for particle adhesion reduction Open
View article: Functionalized Gold Nanoparticles with a Cohesion Enhancer for Robust Flexible Electrodes
Functionalized Gold Nanoparticles with a Cohesion Enhancer for Robust Flexible Electrodes Open
The development of conductive inks is required to enable additive manufacturing of electronic components and devices. A gold nanoparticle (AuNP) ink is of particular interest due to its high electrical conductivity, chemical stability, and…
View article: Correction to “Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomers”
Correction to “Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomers” Open
The chemical structure of the drug trandolapril has been corrected in Figure 4c. The conclusions of the work have not been affected by this correction. (Figure present).
View article: Bio-availability and Bio-accessibility of Lead and Zinc in Contaminated Soil from Cwymystwyth Lead Mine Site
Bio-availability and Bio-accessibility of Lead and Zinc in Contaminated Soil from Cwymystwyth Lead Mine Site Open
Cwmystwyth Lead Mine was an abundant mine site with pugh’s and kingside water drainages shows contaminated water in the research area with no much scientific evidence to ascertain the level of the pollution. Hence this research was designe…
View article: Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to Produce Complex and Personalised Dosage Forms
Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to Produce Complex and Personalised Dosage Forms Open
One of the most striking characteristics of 3D printing is its capability to produce multi-material objects with complex geometry. In pharmaceutics this translates to the possibility of dosage forms with multi-drug loading, tailored dosing…
View article: Gastroretentive Technologies in Tandem with Controlled-Release Strategies: A Potent Answer to Oral Drug Bioavailability and Patient Compliance Implications
Gastroretentive Technologies in Tandem with Controlled-Release Strategies: A Potent Answer to Oral Drug Bioavailability and Patient Compliance Implications Open
There have been many efforts to improve oral drug bioavailability and therapeutic efficacy and patient compliance. A variety of controlled-release oral delivery systems have been developed to meet these needs. Gastroretentive drug delivery…
View article: Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomers
Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomers Open
Controlling the microstructure of materials by means of phase separation is a versatile tool for optimizing material properties. Phase separation has been exploited to fabricate intricate microstructures in many fields including cell biolo…
View article: Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices (Adv. Sci. 15/2021)
Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices (Adv. Sci. 15/2021) Open
Bacterial Biofilm Resistant Composite Devices Medical implants would benefit from bespoke 3D printing, however microbial infection remains a challenge. By combining functional materials, voxelated manufacturing and algorithmic design, Morg…
View article: Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices
Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices Open
As the understanding of disease grows, so does the opportunity for personalization of therapies targeted to the needs of the individual. To bring about a step change in the personalization of medical devices it is shown that multi‐material…
View article: Residual polymer stabiliser causes anisotropic electrical conductivity during inkjet printing of metal nanoparticles
Residual polymer stabiliser causes anisotropic electrical conductivity during inkjet printing of metal nanoparticles Open
View article: 3D printed polymeric drug-eluting implants
3D printed polymeric drug-eluting implants Open
View article: <i>In vitro</i> and <i>in vivo</i> evaluation of a sustained-release once-a-day formulation of the novel antihypertensive drug MT-1207
<i>In vitro</i> and <i>in vivo</i> evaluation of a sustained-release once-a-day formulation of the novel antihypertensive drug MT-1207 Open
Hypertension is one of the most common chronic cardiovascular disorders. Sustained-release formulations are developed to maintain drug therapeutic levels throughout the treatment of hypertension, to promote patient compliance and improve p…
View article: Residual polymer stabiliser causes anisotropic conductivity in metal nanoparticle 2D and 3D printed electronics
Residual polymer stabiliser causes anisotropic conductivity in metal nanoparticle 2D and 3D printed electronics Open
Inkjet printing of metal nanoparticles (MNPs) allows for design flexibility, rapid processing and enables 3D printing of functional electronic devices through co-deposition of multiple materials. However, the performance of printed devices…
View article: Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites
Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites Open
As our understanding of disease grows, it is becoming established that treatment needs to be personalized and targeted to the needs of the individual. In this paper we show that multi-material inkjet-based 3D printing, when backed with gen…
View article: Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites
Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites Open
As our understanding of disease grows, it is becoming established that treatment needs to be personalized and targeted to the needs of the individual. In this paper we show that multi-material inkjet-based 3D printing, when backed with gen…
View article: Microstructural Control of Polymers Achieved Using Controlled Phase Separation During 3D Printing with Oligomer Libraries: Dictating Drug Release for Personalized Subdermal Implants
Microstructural Control of Polymers Achieved Using Controlled Phase Separation During 3D Printing with Oligomer Libraries: Dictating Drug Release for Personalized Subdermal Implants Open
Controlling the microstructure of materials by means of phase separation is a versatile tool for optimizing material properties. In this study, we show that ink jet 3D printing of polymer blends gives rise to controllable phase separation …
View article: Microstructural Control of Polymers Achieved Using Controlled Phase Separation During 3D Printing with Oligomer Libraries: Dictating Drug Release for Personalized Subdermal Implants
Microstructural Control of Polymers Achieved Using Controlled Phase Separation During 3D Printing with Oligomer Libraries: Dictating Drug Release for Personalized Subdermal Implants Open
Controlling the microstructure of materials by means of phase separation is a versatile tool for optimizing material properties. In this study, we show that ink jet 3D printing of polymer blends gives rise to controllable phase separation …
View article: Prodrugs: A Reactive Prodrug Ink Formulation Strategy for Inkjet 3D Printing of Controlled Release Dosage Forms and Implants (Adv. Therap. 6/2020)
Prodrugs: A Reactive Prodrug Ink Formulation Strategy for Inkjet 3D Printing of Controlled Release Dosage Forms and Implants (Adv. Therap. 6/2020) Open
In article number 1900187 by Clive J. Roberts, Ricky D. Wildman and co-workers report an entirely new approach to formulating and controlling drug release from 3D printed systems/implants. This approach allows for hierarchical control over…
View article: A Reactive Prodrug Ink Formulation Strategy for Inkjet 3D Printing of Controlled Release Dosage Forms and Implants
A Reactive Prodrug Ink Formulation Strategy for Inkjet 3D Printing of Controlled Release Dosage Forms and Implants Open
A strategy for creating tuneable 3D printed drug delivery devices is proposed. 3D printing offers the opportunity for improved compliance and patient treatment outcomes through personalization, but bottlenecks include finding formulations …
View article: Development of an In Vitro System to Study the Interactions of Aerosolized Drugs with Pulmonary Mucus
Development of an In Vitro System to Study the Interactions of Aerosolized Drugs with Pulmonary Mucus Open
Mucus is the first biological component inhaled drugs encounter on their journey towards their pharmacological target in the upper airways. Yet, how mucus may influence drug disposition and efficacy in the lungs has been essentially overlo…
View article: A 3D printed drug delivery implant formed from a dynamic supramolecular polyurethane formulation
A 3D printed drug delivery implant formed from a dynamic supramolecular polyurethane formulation Open
Prototype drug eluting implants have been 3D printed using a supramolecular polyurethane-PEG formulation. The implants are capable of releasing a pharmaceutical active with effective drug release over a period of up to 8.5 months.
View article: Is rat a good model for assessment of particulate-based taste-masked formulations?
Is rat a good model for assessment of particulate-based taste-masked formulations? Open
View article: Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing
Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing Open
View article: Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer
Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer Open