Clorinda Arias
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View article: Tau–Mitochondria Interactions in Neurodegeneration: Mechanisms and Therapeutic Potential
Tau–Mitochondria Interactions in Neurodegeneration: Mechanisms and Therapeutic Potential Open
Tau is a microtubule-associated protein encoded by the MAPT gene and is mainly expressed in neurons. Alternative splicing generates preferentially six isoforms differing in N-terminal inserts (0, 1, or 2N) and microtubule-binding repeats (…
View article: Tau Protein Disrupts Mitochondrial Homeostasis in a Yeast Model: Implications for Alzheimer’s Disease
Tau Protein Disrupts Mitochondrial Homeostasis in a Yeast Model: Implications for Alzheimer’s Disease Open
The microtubule-associated protein tau plays a central role in neurodegenerative diseases, called tauopathies, but the mechanism involved remains incompletely understood. Here, we used Saccharomyces cerevisiae as a model system to investig…
View article: Intracerebral administration of Wnt7a improves memory performance and increases synaptophysin expression in the 3xTg-AD mouse model
Intracerebral administration of Wnt7a improves memory performance and increases synaptophysin expression in the 3xTg-AD mouse model Open
Wnt signaling has emerged as an important pathway involved in the expression of some Alzheimeŕs disease hallmarks. In the adult brain, Wnt signaling regulates synaptic structure and function and has a role in synaptogenesis, synaptic trans…
View article: Palmitic Acid Induces Dynamic Time-Dependent Alterations in HDACs, Neuronal Chromatin Acetylation, and Gene Expression
Palmitic Acid Induces Dynamic Time-Dependent Alterations in HDACs, Neuronal Chromatin Acetylation, and Gene Expression Open
Chronic consumption of high fat diets (HFD) is a risk factor for the development of metabolic diseases such as obesity and diabetes, and it is also associated with cognitive impairment and Alzheimer´s disease. Palmitic acid (PA) is a major…
View article: Role of saturated fatty acid metabolism in posttranslational modifications of the Tau protein
Role of saturated fatty acid metabolism in posttranslational modifications of the Tau protein Open
The relationship between metabolic alterations induced by the consumption of a high-fat diet (HFD) and the risk of developing neurodegenerative diseases such as Alzheimer’s disease (AD) has been extensively studied. In particular, the indu…
View article: Involvement of the VGF/BDNF axis in the neuropathology of Alzheimer’s disease and its potential role in diagnosis and treatment
Involvement of the VGF/BDNF axis in the neuropathology of Alzheimer’s disease and its potential role in diagnosis and treatment Open
The brain is a highly plastic organ that continually receives and integrates signals to generate functional and structural changes and homeostatic adaptations throughout life. Alterations in some signaling pathways that mediate these respo…
View article: Eraña, Ángeles. (2021). Un mundo que hila personas (o de la inexistencia de la paradoja individuo/sociedad). Instituto de Investigaciones Filosóficas, Universidad Nacional Autónoma de México, Universidad Autónoma Metropolitana.
Eraña, Ángeles. (2021). Un mundo que hila personas (o de la inexistencia de la paradoja individuo/sociedad). Instituto de Investigaciones Filosóficas, Universidad Nacional Autónoma de México, Universidad Autónoma Metropolitana. Open
View article: Age- and Sex-Associated Wnt Signaling Dysregulation is Exacerbated from the Early Stages of Neuropathology in an Alzheimer’s Disease Model
Age- and Sex-Associated Wnt Signaling Dysregulation is Exacerbated from the Early Stages of Neuropathology in an Alzheimer’s Disease Model Open
Emerging studies suggest that Wnt signaling is dysregulated in the brains of AD patients, suggesting that this pathway may also contribute to disease progression. However, it remains to be determined whether alterations in the Wnt pathway …
View article: Age- and sex-associated Wnt signaling dysregulation is exacerbated from the early stages of neuropathology in an Alzheimer´s disease model
Age- and sex-associated Wnt signaling dysregulation is exacerbated from the early stages of neuropathology in an Alzheimer´s disease model Open
Emerging studies suggest that Wnt signaling is dysregulated in the brains of AD patients, suggesting that this pathway may also contribute to disease progression. However, it remains to be determined whether alterations in the Wnt pathway …
View article: Palmitic Acid Induces Posttranslational Modifications of Tau Protein in Alzheimer’s Disease–Related Epitopes and Increases Intraneuronal Tau Levels
Palmitic Acid Induces Posttranslational Modifications of Tau Protein in Alzheimer’s Disease–Related Epitopes and Increases Intraneuronal Tau Levels Open
View article: Supplementation with EPA and DHA omega-3 fatty acids improves peripheral immune cell mitochondrial dysfunction and inflammation in subjects with obesity
Supplementation with EPA and DHA omega-3 fatty acids improves peripheral immune cell mitochondrial dysfunction and inflammation in subjects with obesity Open
Omega-3 fatty acids (w-3 FA) have anti-inflammatory effects and improve mitochondrial function. Nonetheless, little is known about their effect on mitochondrial bioenergetics of peripheral blood mononuclear cells (PBMCs) in individuals wit…
View article: Palmitic acid induces posttranslational modifications of tau protein in Alzheimer´s disease-related epitopes and increases intraneuronal tau levels.
Palmitic acid induces posttranslational modifications of tau protein in Alzheimer´s disease-related epitopes and increases intraneuronal tau levels. Open
Metabolic diseases derived from an unhealthy lifestyle have been linked with an increased risk for developing cognitive impairment and even Alzheimer´s disease (AD). Although high consumption of saturated fatty acids such as palmitic acid …
View article: Differential effects of high dose omega-3 fatty acids on metabolism and inflammation in patients with obesity: eicosapentaenoic and docosahexaenoic acid supplementation
Differential effects of high dose omega-3 fatty acids on metabolism and inflammation in patients with obesity: eicosapentaenoic and docosahexaenoic acid supplementation Open
Background Obesity is complicated by low-grade chronic inflammation characterised by increases in inflammatory proteins and cells in peripheral blood. It has been known that omega-3 fatty acids (FA) like eicosapentaenoic (EPA) and docosahe…
View article: Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage
Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage Open
Introduction Saturated fatty acids (FAs) are the main component of high‐fat diets (HFDs), and high consumption has been associated with the development of insulin resistance, endoplasmic reticulum stress and mitochondrial dysfunction in ne…
View article: Transcriptional Profiles Reveal Deregulation of Lipid Metabolism and Inflammatory Pathways in Neurons Exposed to Palmitic Acid
Transcriptional Profiles Reveal Deregulation of Lipid Metabolism and Inflammatory Pathways in Neurons Exposed to Palmitic Acid Open
View article: Transcriptional profiles reveal deregulation of lipid metabolism and inflammatory pathways in neurons exposed to palmitic acid
Transcriptional profiles reveal deregulation of lipid metabolism and inflammatory pathways in neurons exposed to palmitic acid Open
The effects of the consumption of high-fat diets (HFD) have been studied to unravel the molecular pathways they are altering in order to understand the link between increased caloric intake, metabolic diseases, and the risk of cognitive dy…
View article: Age-Dependent Decline in Synaptic Mitochondrial Function Is Exacerbated in Vulnerable Brain Regions of Female 3xTg-AD Mice
Age-Dependent Decline in Synaptic Mitochondrial Function Is Exacerbated in Vulnerable Brain Regions of Female 3xTg-AD Mice Open
Synaptic aging has been associated with neuronal circuit dysfunction and cognitive decline. Reduced mitochondrial function may be an early event that compromises synaptic integrity and neurotransmission in vulnerable brain regions during p…
View article: Differential Regulation of Wnt Signaling Components During Hippocampal Reorganization After Entorhinal Cortex Lesion
Differential Regulation of Wnt Signaling Components During Hippocampal Reorganization After Entorhinal Cortex Lesion Open
View article: Palmitic Acid-Induced NAD+ Depletion is Associated with the Reduced Function of SIRT1 and Increased Expression of BACE1 in Hippocampal Neurons
Palmitic Acid-Induced NAD+ Depletion is Associated with the Reduced Function of SIRT1 and Increased Expression of BACE1 in Hippocampal Neurons Open
View article: Food for Thought: What Happens to the Brain When We Eat Foods High in Fat and Sugar?
Food for Thought: What Happens to the Brain When We Eat Foods High in Fat and Sugar? Open
Have you ever wondered how different foods in your diet affect your brain? The brain is an extraordinary organ in charge of an astounding number of functions in your body. This is why the brain requires high-quality nutrients found in the …
View article: Differential Changes in the Number and Morphology of the New Neurons after Chronic Infusion of Wnt7a, Wnt5a, and Dkk‐1 in the Adult Hippocampus <i>In Vivo</i>
Differential Changes in the Number and Morphology of the New Neurons after Chronic Infusion of Wnt7a, Wnt5a, and Dkk‐1 in the Adult Hippocampus <i>In Vivo</i> Open
In the adult hippocampus of many mammals, a particular microenvironment in the neurogenic niche regulates the proliferation, self‐renewal, and differentiation of neuronal stem cells. In this proliferative niche, a variety of molecules prov…
View article: PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions
PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions Open
Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth, proliferation, and survival. Less is known regarding…
View article: Modificaciones celulares relacionadas con la enfermedad de Alzheimer
Modificaciones celulares relacionadas con la enfermedad de Alzheimer Open
La enfermedad de Alzheimer (EA) es una de las principales causas de pérdida de la memoria y de capacidad intelectual en la vida adulta. Este padecimiento fue descrito en 1907 por Alois Alzheimer y se conoce que aproximadamente un 15%…
View article: Do new neurons contribute to functional reorganization after brain damage?
Do new neurons contribute to functional reorganization after brain damage? Open
The finding that adult neurogenesis occurs constitutively in the brain was a breakthrough in neuroscience and soon gained attention as a possible mechanism for neurorepair after brain damage. In a recent study we show that the dentate gyru…
View article: Nonsteroidal anti-inflammatory drugs attenuate amyloid-β protein-induced actin cytoskeletal reorganization through Rho signaling modulation
Nonsteroidal anti-inflammatory drugs attenuate amyloid-β protein-induced actin cytoskeletal reorganization through Rho signaling modulation Open
View article: Behavior‐associated Neuronal Activation After Kainic Acid‐induced Hippocampal Neurotoxicity is Modulated in Time
Behavior‐associated Neuronal Activation After Kainic Acid‐induced Hippocampal Neurotoxicity is Modulated in Time Open
Kainic acid‐induced (KA) hippocampal damage leads to neuronal death and further synaptic plasticity. Formation of aberrant as well as of functional connections after such procedure has been documented. However, the impact of such structura…
View article: Identification of age- and disease-related alterations in circulating miRNAs in a mouse model of Alzheimer's disease
Identification of age- and disease-related alterations in circulating miRNAs in a mouse model of Alzheimer's disease Open
Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by the progressive decline of memory and cognition. Histopathologically, two main hallmarks have been identified in AD: amyloid-β peptide extracellular neuri…