Explanipedia

Non-human primate model of long-COVID identifies immune associates of hyperglycemia Open

Clovis S. Palmer, Chrysostomos Perdios, Mohamed Abdel‐Mohsen, Joseph C. Mudd, Prasun K. Datta , et al. · 2024

Prepandemic Metabolic Correlates of Coronavirus Disease 2019 (COVID-19) Severity and Long COVID Incidence in People Living With HIV Open

Priyesh Agrawal, Leila B. Giron, Shalini Singh, Nel Jason Haw, Aaron R. Goldman , et al. · 2024

Host metabolic dysregulation, especially in tryptophan metabolism, is intricately linked to coronavirus disease 2019 (COVID-19) severity and its postacute sequelae (long COVID). People living with human immunodeficiency virus (HIV; PLWH) e…

Immune Correlates of Hyperglycemia and Vaccination in a Non-human Primate Model of Long-COVID Open

Clovis S. Palmer, Chrysostomos Perdios, Mohamed Abdel‐Mohsen, Joseph C. Mudd, Prasun K. Datta , et al. · 2023

Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are major manifestations of the post-acute sequelae of SARS-CoV-2 (PASC). Our understanding of lasting glucometabolic disruptions after acute COVID-19 remains …

Immune Correlates of Hyperglycemia and Vaccination in a Non-human Primate Model of Long-COVID Open

Clovis S. Palmer, Chrysostomos Perdios, Mohamed Abdel‐Mohsen, Joseph C. Mudd, Prasun K. Datta , et al. · 2023

Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are major manifestations of the post-acute sequelae of SARS-CoV-2 (PASC). Our understanding of lasting glucometabolic disruptions after acute COVID-19 remains …

A Systematic Review of the Clinical Diagnosis of Transient Hypogammaglobulinemia of Infancy Open

Angel A Justiz-Vaillant, Trudee Hoyte, Nikao Davis, Candice Deonarinesingh, Amir De Silva , et al. · 2023

Transient hypogammaglobulinemia of infancy (THI) is a primary immunodeficiency caused by a temporary decline in serum immunoglobulin G (IgG) levels greater than two standard deviations below the mean age-specific reference values in infant…

Chronic Granulomatous Disease (CGD): Pathogens and Management Open

Angel A Justiz-Vaillant, Arlene Williams, Rodolfo Arozarena-Fundora, Darren Gopaul, Sachin Soodeen , et al. · 2023

Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by a defect in the phagocytic function of the innate immune system owing to mutations in genes encoding the five subunits of the nicotinamide adenine dinucleotide (NA…

SARS-CoV-2 infection dysregulates NAD metabolism Open

Amin Izadpanah, Joseph C. Mudd, Joe G. N. Garcia, Sudesh Srivastav, Mohamed Abdel‐Mohsen , et al. · 2023

Introduction Severe COVID-19 results initially in pulmonary infection and inflammation. Symptoms can persist beyond the period of acute infection, and patients with Post-Acute Sequelae of COVID (PASC) often exhibit a variety of symptoms we…

A Systematic Review on the Clinical Diagnosis of Transient Hypogammaglobulinemia of Infants Open

Angel A Justiz-Vaillant, Nikao Davis, Candice Deonarinesingh, Amir De Silva, Dylan Dhanpaul , et al. · 2023

Background: Transient Hypogammaglobulinemia of Infancy (THI) is a primary immunodeficiency caused by a temporary decline of serum levels of immunoglobulin G (IgG) greater than 2 standard deviations below the mean age-specific reference val…

Innate metabolic responses against viral infections Open

Clovis S. Palmer · 2022

Elevated CD4+ T-cell glucose metabolism in HIV+ women with diabetes mellitus Open

Tiffany R. Butterfield, David B. Hanna, Robert C. Kaplan, Xiaonan Xue, Jorge R. Kizer , et al. · 2022

Objective: Immune dysfunction and chronic inflammation are characteristic of HIV infection and diabetes mellitus, with CD4 + T-cell metabolism implicated in the pathogenesis of each disease. However, there is limited information on CD4 + T…

Corrigendum: Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients Open

Leila B. Giron, Harsh Dweep, Xiangfan Yin, Han Wang, Mohammad Damra , et al. · 2021

[This corrects the article DOI: 10.3389/fimmu.2021.686240.].

Non-Invasive Plasma Glycomic and Metabolic Biomarkers of Post-treatment Control of HIV Open

Leila B. Giron, Clovis S. Palmer, Qin Liu, Xiangfan Yin, Emmanouil Papasavvas , et al. · 2020

Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such biomarkers can improve the safety of analytic treatment interruption (ATI) and provide mechanistic insights into t…

CD4 T Cell Metabolism Is a Major Contributor of HIV Infectivity and Reservoir Persistence Open

Harry E. Taylor, Clovis S. Palmer · 2020

HIV infection is characterized by elevated glycolytic metabolism in CD4 T cells. In their recent study, Valle-Casuso et al. demonstrated that both increased glucose utilization and glutamine metabolism are essential for HIV infectivity and…

Inflammatory and immunometabolic consequences of gut dysfunction in HIV: Parallels with IBD and implications for reservoir persistence and non-AIDS comorbidities Open

Jehad Alzahrani, Tabinda Hussain, David Simar, Riya Palchaudhuri, Mohamed Abdel‐Mohsen , et al. · 2019

Obesity and Fat Metabolism in Human Immunodeficiency Virus–Infected Individuals: Immunopathogenic Mechanisms and Clinical Implications Open

Catherine Godfrey, Andrew A. Bremer, Diana Alba, Caroline M. Apovian, John R. Koethe , et al. · 2019

Metabolic complications relating to complex effects of viral and immune-mediated mechanisms are now a focus of clinical care among persons living with human immunodeficiency virus (PLHIV), and obesity is emerging as a critical problem. To …

Induction of HIF-1α by HIV-1 Infection in CD4 <sup>+</sup> T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation Open

Gabriel Duette, Pehuén Pereyra Gerber, Julia Rubione, Paula S. Pérez, Alan Landay , et al. · 2018

Human immunodeficiency virus type 1 (HIV-1) is a very important global pathogen that preferentially targets CD4 + T cells and causes acquired immunodeficiency syndrome (AIDS) if left untreated. Although antiretroviral treatment efficiently…

Suppression of monocyte inflammatory and coagulopathy responses in HIV infection Open

Reena Rajasuriar, Anna C. Hearps, Suzanne M. Crowe, Joshua J. Anzinger, Clovis S. Palmer · 2018

The increased access globally to effective antiretroviral therapy (ART) among people living with HIV (PLHIV) has led to a change in the demographics of this population (1,2). Once considered a death sentence, HIV infection has now evolved …

Polymorphism rs1385129 Within Glut1 Gene SLC2A1 Is Linked to Poor CD4+ T Cell Recovery in Antiretroviral-Treated HIV+ Individuals Open

Jesse J. R. Masson, Catherine L. Cherry, Nicholas M. Murphy, Isabel Sada‐Ovalle, Tabinda Hussain , et al. · 2018

Untreated HIV infection is associated with progressive CD4+ T cell depletion, which is generally recovered with combination antiretroviral therapy (cART). However, a significant proportion of cART-treated individuals have poor CD4+ T cell …

Exploiting immune cell metabolic machinery for functional HIV cure and the prevention of inflammaging Open

Clovis S. Palmer, Riya Palchaudhuri, Hassan Albargy, Mohamed Abdel‐Mohsen, Suzanne M. Crowe · 2018

An emerging paradigm in immunology suggests that metabolic reprogramming and immune cell activation and functions are intricately linked. Viral infections, such as HIV infection, as well as cancer force immune cells to undergo major metabo…

Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections Open

Hesham M. Shehata, Andrew Murphy, Man Kit Sam Lee, Clair M. Gardiner, Suzanne M. Crowe , et al. · 2017

The realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogram…

Assessment of metabolic and mitochondrial dynamics in CD4+ and CD8+ T cells in virologically suppressed HIV-positive individuals on combination antiretroviral therapy Open

Jesse J. R. Masson, Andrew Murphy, Man K.S. Lee, Matías Ostrowski, Suzanne M. Crowe , et al. · 2017

Metabolism plays a fundamental role in supporting the growth, proliferation and effector functions of T cells. We investigated the impact of HIV infection on key processes that regulate glucose uptake and mitochondrial biogenesis in subpop…

Metabolic reprogramming during hepatitis B disease progression offers novel diagnostic and therapeutic opportunities Open

Jesse J. R. Masson, Hugh Billings, Clovis S. Palmer · 2017

Metabolic remodeling occurs in immune cells during an infection. Host cells must upregulate energy production for growth, proliferation, and effector functions to limit the damage imposed by pathogens. One example, the hepatitis B virus, i…

Measurement of Aortic Cell Fluid-Phase Pinocytosis in vivo by Flow Cytometry Open

Joshua J. Anzinger, Xueting Jin, Clovis S. Palmer, Pradeep K. Dagur, Manoj Kumar Barthwal , et al. · 2017

Objective: Fluid-phase pinocytosis is a receptor-independent mechanism of endocytosis that occurs in all mammalian cells and may be a mechanism for the uptake of LDL by macrophages. As there are currently no methods for the m…

Increased glucose transporter-1 expression on intermediate monocytes from HIV-infected women with subclinical cardiovascular disease Open

Tiffany R. Butterfield, David B. Hanna, Robert C. Kaplan, Jorge R. Kizer, Helen G. Durkin , et al. · 2016

GLUT1-expressing intermediate monocytes are elevated in HIV-infected women with subclinical CVD. These cells may contribute to development of CVD in PLWH and could be a novel target to limit inflammation.

Emerging Role and Characterization of Immunometabolism: Relevance to HIV Pathogenesis, Serious Non-AIDS Events, and a Cure Open

Clovis S. Palmer, Darren C. Henstridge, Di Yu, Amit Singh, Brad Balderson , et al. · 2016

Immune cells cycle between a resting and an activated state. Their metabolism is tightly linked to their activation status and, consequently, functions. Ag recognition induces T lymphocyte activation and proliferation and acquisition of ef…

Glucose Metabolism in T Cells and Monocytes: New Perspectives in HIV Pathogenesis Open

Clovis S. Palmer, Catherine L. Cherry, Isabel Sada‐Ovalle, Amit Singh, Suzanne M. Crowe · 2016

Monocytes from HIV-infected individuals show impaired cholesterol efflux and increased foam cell formation after transendothelial migration Open

Anna Maisa, Anna C. Hearps, Thomas A. Angelovich, Cândida F. Pereira, Jingling Zhou , et al. · 2015

Monocytes from HIV+ individuals show impaired cholesterol efflux and are primed for foam cell formation following transendothelial migration. Factors present in HIV+ serum, including elevated TNF levels, further enhance foam cell formation…

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions Open

Clovis S. Palmer, Matías Ostrowski, Brad Balderson, Nicole Christian, Suzanne M. Crowe · 2015

The adaptive immune system is equipped to eliminate both tumors and pathogenic microorganisms. It requires a series of complex and coordinated signals to drive the activation, proliferation, and differentiation of appropriate T cell subset…

Clovis S. Palmer YOU? Author Swipe