Clovis Tauber
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View article: Inhibition of p38α MAPK increases short-term astrocyte reactivity: the exploratory VIP trial in early Alzheimer’s disease
Inhibition of p38α MAPK increases short-term astrocyte reactivity: the exploratory VIP trial in early Alzheimer’s disease Open
International audience
View article: Environmental enrichment selectively restores brain metabolic activity during cocaine abstinence
Environmental enrichment selectively restores brain metabolic activity during cocaine abstinence Open
Background Environmental enrichment (EE) is a promising strategy to promote recovery from addiction, but its neurobiological mechanisms remain poorly understood. This study investigates how exposure to EE during abstinence dynamically affe…
View article: MyData: A Comprehensive Database of Mycetoma Tissue Microscopic Images for Histopathological Analysis
MyData: A Comprehensive Database of Mycetoma Tissue Microscopic Images for Histopathological Analysis Open
Mycetoma is a chronic and neglected inflammatory disease prevalent in tropical and subtropical regions. It can lead to severe disability and social stigma. The disease is classified into two types based on the causative microorganisms: eum…
View article: Neuroimmune activation is associated with neurological outcome in anoxic and traumatic coma
Neuroimmune activation is associated with neurological outcome in anoxic and traumatic coma Open
The pathophysiological underpinnings of critically disrupted brain connectomes resulting in coma are poorly understood. Inflammation is potentially an important but still undervalued factor. Here, we present a first-in-human prospective st…
View article: Neuroimmune activation is associated with neurological outcome in anoxic and traumatic coma
Neuroimmune activation is associated with neurological outcome in anoxic and traumatic coma Open
International audience
View article: QU-BraTS: MICCAI BraTS 2020 Challenge on Quantifying Uncertainty in Brain Tumor Segmentation – Analysis of Ranking Scores and Benchmarking Results
QU-BraTS: MICCAI BraTS 2020 Challenge on Quantifying Uncertainty in Brain Tumor Segmentation – Analysis of Ranking Scores and Benchmarking Results Open
Deep learning (DL) models have provided the state-of-the-art performance in a wide variety of medical imaging benchmarking challenges, including the Brain Tumor Segmentation (BraTS) challenges. However, the task of focal pathology multi-co…
View article: Persistent neuroinflammation and behavioural deficits after single mild traumatic brain injury
Persistent neuroinflammation and behavioural deficits after single mild traumatic brain injury Open
Despite an apparently silent imaging, some patients with mild traumatic brain injury (TBI) experience cognitive dysfunctions, which may persist chronically. Brain changes responsible for these dysfunctions are unclear and commonly overlook…
View article: Performance evaluation of the IRIS XL-220 PET/CT system, a new camera dedicated to non-human primates
Performance evaluation of the IRIS XL-220 PET/CT system, a new camera dedicated to non-human primates Open
Background Non-human primates (NHP) are critical in biomedical research to better understand the pathophysiology of diseases and develop new therapies. Based on its translational and longitudinal abilities along with its non-invasiveness, …
View article: Trans ε-Viniferin Decreases Amyloid Deposits With Greater Efficiency Than Resveratrol in an Alzheimer’s Mouse Model
Trans ε-Viniferin Decreases Amyloid Deposits With Greater Efficiency Than Resveratrol in an Alzheimer’s Mouse Model Open
In a previous study, we showed that viniferin decreased amyloid deposits and reduced neuroinflammation in APPswePS1dE9 transgenic mice between 3 and 6 months of age. In the present study, wild type and APPswePS1dE9 transgenic mice were tre…
View article: QU-BraTS: MICCAI BraTS 2020 Challenge on Quantifying Uncertainty in Brain Tumor Segmentation - Analysis of Ranking Scores and Benchmarking Results
QU-BraTS: MICCAI BraTS 2020 Challenge on Quantifying Uncertainty in Brain Tumor Segmentation - Analysis of Ranking Scores and Benchmarking Results Open
Deep learning (DL) models have provided state-of-the-art performance in various medical imaging benchmarking challenges, including the Brain Tumor Segmentation (BraTS) challenges. However, the task of focal pathology multi-compartment segm…
View article: Asymmetric Ensemble of Asymmetric U-Net Models for Brain Tumor Segmentation With Uncertainty Estimation
Asymmetric Ensemble of Asymmetric U-Net Models for Brain Tumor Segmentation With Uncertainty Estimation Open
Accurate brain tumor segmentation is crucial for clinical assessment, follow-up, and subsequent treatment of gliomas. While convolutional neural networks (CNN) have become state of the art in this task, most proposed models either use 2D a…
View article: Radiomics Model for Mycetoma Grains Classification from Histopathological Microscopic Images Using Partial Least Squares Discriminant Analysis (PLS-DA)
Radiomics Model for Mycetoma Grains Classification from Histopathological Microscopic Images Using Partial Least Squares Discriminant Analysis (PLS-DA) Open
18 pages, 41 ref.
View article: Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study
Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study Open
Mouse models of Alzheimer's disease (AD) are valuable but do not fully recapitulate human AD pathology, such as spontaneous Tau fibril accumulation and neuronal loss, necessitating the development of new AD models. The transgenic (TG) TgF3…
View article: Compartment model-based nonlinear unmixing for kinetic analysis of dynamic PET images
Compartment model-based nonlinear unmixing for kinetic analysis of dynamic PET images Open
When no arterial input function is available, quantification of dynamic PET images requires a previous step devoted to the extraction of a reference time-activity curve (TAC). Factor analysis is often applied for this purpose. This paper i…
View article: A new partial differential equation for image inpainting
A new partial differential equation for image inpainting Open
A considerable interest in the inpainting problem have attracted many researchers in applied mathematics community. In fact in the last decade, nonlinear high order partial dierential equations have payed a central role in high quality inp…
View article: Usefulness of PET With [18F]LBT-999 for the Evaluation of Presynaptic Dopaminergic Neuronal Loss in a Clinical Environment
Usefulness of PET With [18F]LBT-999 for the Evaluation of Presynaptic Dopaminergic Neuronal Loss in a Clinical Environment Open
Purpose: The density of the neuronal dopamine transporter (DAT) is directly correlated with the presynaptic dopaminergic system injury. In a first study, we evaluated the brain distribution and kinetics of [18F]LBT-999, a DAT PET radioliga…
View article: Raman mapping coupled to self‐modelling <scp>MCR‐ALS</scp> analysis to estimate active cosmetic ingredient penetration profile in skin
Raman mapping coupled to self‐modelling <span>MCR‐ALS</span> analysis to estimate active cosmetic ingredient penetration profile in skin Open
Confocal Raman mapping (CRM) is a powerful, label free, non‐destructive tool, enabling molecular characterization of human skin with applications in the dermo‐cosmetic field. Coupling CRM to multivariate analysis can be used to monitor the…
View article: Efficacy of chronic ultrasound neurostimulation on behaviors and distributed brain metabolism in depressive-like mice
Efficacy of chronic ultrasound neurostimulation on behaviors and distributed brain metabolism in depressive-like mice Open
Major depression is one of the main factors contributing to the Global Burden of Disease. Current treatment strategies ( e.g., antidepressants and neurostimulation techniques) of major depression show some limitations including inaccuracy …
View article: Assessment of simplified methods for quantification of [<sup>18</sup>F]-DPA-714 using 3D whole-brain TSPO immunohistochemistry in a non-human primate
Assessment of simplified methods for quantification of [<sup>18</sup>F]-DPA-714 using 3D whole-brain TSPO immunohistochemistry in a non-human primate Open
The 18 kDa translocator protein (TSPO) is the main molecular target to image neuroinflammation by positron emission tomography (PET). However, TSPO-PET quantification is complex and none of the kinetic modelling approaches has been validat…