Caroline M. Moore
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View article: Interventions for patients with prostate cancer on active surveillance: a narrative review
Interventions for patients with prostate cancer on active surveillance: a narrative review Open
Objective To examine contemporary evidence supporting non‐surgical interventions for patients with early prostate cancer (PCa) on active surveillance (AS). Methods A literature search was conducted using the databases PubMed, Medline, and …
View article: Diagnostic accuracy of abbreviated biparametric MRI for prostate cancer screening: a prospective feasibility study (ReIMAGINE study)
Diagnostic accuracy of abbreviated biparametric MRI for prostate cancer screening: a prospective feasibility study (ReIMAGINE study) Open
Objectives To evaluate the diagnostic accuracy and imaging findings of an abbreviated biparametric MRI (bpMRI) protocol for prostate cancer (PCa) screening. Materials and methods In this single-centre, prospective study, men aged 50–75 yea…
View article: Geographic variability in contemporary utilization of PET imaging for prostate cancer: a medicare claims cohort study
Geographic variability in contemporary utilization of PET imaging for prostate cancer: a medicare claims cohort study Open
Background Potential rural-urban differences in prostate cancer care are understudied, particularly regarding the utilization of advanced diagnostic tests. Herein we examined variations in Positron Emission Tomography (PET) utilization for…
View article: Magnetic Resonance Imaging–led Risk-adapted Active Surveillance for Prostate Cancer: Updated Results from a Large Cohort Study
Magnetic Resonance Imaging–led Risk-adapted Active Surveillance for Prostate Cancer: Updated Results from a Large Cohort Study Open
MRI visibility and secondary Gleason pattern 4 at baseline are associated with progression to treatment and to primary Gleason pattern 4 during MRI-led AS.
View article: Disparities in tissue-based biomarker testing among US Medicare beneficiaries with prostate cancer
Disparities in tissue-based biomarker testing among US Medicare beneficiaries with prostate cancer Open
Background Personalized therapeutic approaches for localized prostate cancer have evolved significantly, with tissue-based biomarker tests supplementing traditional risk stratification tools. However, national testing patterns and geograph…
View article: How clinically relevant and inclusive are prostate cell lines?
How clinically relevant and inclusive are prostate cell lines? Open
Cell line experiments arguably remain the most used tool in preclinical cancer research. Given that PCa cell lines form a major part of this preclinical framework, evaluating their relevance is crucial to improving the predictive power of …
View article: Study protocol for the randomized controlled trial of EMBOLDEN: a multifaceted intervention aimed at Enhancing physical and community MoBility in OLDEr adults with health inequities using commuNity co-design
Study protocol for the randomized controlled trial of EMBOLDEN: a multifaceted intervention aimed at Enhancing physical and community MoBility in OLDEr adults with health inequities using commuNity co-design Open
Background Reduced physical mobility is common in older adults and is associated with adverse outcomes, including functional decline, depression, social isolation, and poor nutritional status. Group-based programs focusing on physical acti…
View article: Personalized risk-adapted models in prostate cancer during active surveillance using MRI—a narrative review
Personalized risk-adapted models in prostate cancer during active surveillance using MRI—a narrative review Open
The presence of histologically defined prostate cancer (PCa) is common and rises with age. Nevertheless, histological evidence of PCa does not always lead to clinically evident or life-threatening disease, and we know that PSA-based popula…
View article: Requirements for AI Development and Reporting for MRI Prostate Cancer Detection in Biopsy-Naive Men: PI-RADS Steering Committee, Version 1.0
Requirements for AI Development and Reporting for MRI Prostate Cancer Detection in Biopsy-Naive Men: PI-RADS Steering Committee, Version 1.0 Open
This document provides guidance based on subspecialty expertise from the Prostate Imaging Reporting and Data System Steering Committee for the development of an artificial intelligence interpretation model for prostate cancer in biopsy-nai…
View article: B2B: Prostate Cancer Summary
B2B: Prostate Cancer Summary Open
The 6th Bench-to-Bedside Uro-Oncology: GU Cancers Triad Meeting, organized in conjunction with the 44th Annual Congress of the Société Internationale d’Urologie, was held on 25 October 2024, in New Delhi, India, and transmitted live on the…
View article: Validation of in vivo VERDICT fIC against matched histology from whole-mount prostatectomy
Validation of in vivo VERDICT fIC against matched histology from whole-mount prostatectomy Open
Motivation: Intracellular volume fraction (fIC) maps from VERDICT-MRI have shown potential to improve prostate cancer (PCa) stratification, but the microstructural origin of the signal has not yet been investigated in in vivo settings. Goa…
View article: The RECONCILE study protocol: Exploiting image-based risk stratification in early prostate cancer to discriminate progressors from non-progressors (RECONCILE)
The RECONCILE study protocol: Exploiting image-based risk stratification in early prostate cancer to discriminate progressors from non-progressors (RECONCILE) Open
Introduction RECONCILE (ClinicalTrials.gov:NCT04340245) will identify molecular and radiomic markers associated with clinical progression and radiological progression events in a cohort of localised, newly diagnosed Gleason 3 + 4 tumours. …
View article: When is prostate cancer really cancer?
When is prostate cancer really cancer? Open
Prostate cancer (PC) is a major cause of cancer-related deaths worldwide, with far more diagnoses than deaths annually. Recent discussions have challenged whether Grade Group 1 (GG1) PC should be labeled “cancer” due to its indolent nature…
View article: VISION: An Individual Patient Data Meta-analysis of Randomised Trials Comparing Magnetic Resonance Imaging Targeted Biopsy with Standard Transrectal Ultrasound Guided Biopsy in the Detection of Prostate Cancer
VISION: An Individual Patient Data Meta-analysis of Randomised Trials Comparing Magnetic Resonance Imaging Targeted Biopsy with Standard Transrectal Ultrasound Guided Biopsy in the Detection of Prostate Cancer Open
The MRI ± TB pathway is superior to TRUS biopsy in detecting csPCa and avoiding the diagnosis of cisPCa. MRI should be included in the standard of care pathway for prostate cancer diagnosis.
View article: Has Active Surveillance for Prostate Cancer Become Safer? Lessons Learned from a Global Clinical Registry
Has Active Surveillance for Prostate Cancer Become Safer? Lessons Learned from a Global Clinical Registry Open
Active surveillance (AS) has evolved into a widely applied treatment strategy for many men with prostate cancer around the world. In this report, we show the long-term safety of following AS for men with low- and intermediate-risk prostate…
View article: ssVERDICT: Self‐supervised VERDICT‐MRI for enhanced prostate tumor characterization
ssVERDICT: Self‐supervised VERDICT‐MRI for enhanced prostate tumor characterization Open
Purpose Demonstrating and assessing self‐supervised machine‐learning fitting of the VERDICT (vascular, extracellular and restricted diffusion for cytometry in tumors) model for prostate cancer. Methods We derive a self‐supervised neural ne…
View article: Footprints in the scan: reducing the carbon footprint of diagnostic tools in urology
Footprints in the scan: reducing the carbon footprint of diagnostic tools in urology Open
Purpose of review There is an ever-growing focus on climate change and its impact on our society. With healthcare contributing a sizeable proportion of carbon emissions, the sector has a duty to address its environmental impact. We highlig…
View article: Urinary and Sexual Impact of Robotic Radical Prostatectomy: Reporting of Patient-reported Outcome Measures in the First Year after Radical Prostatectomy in a Contemporary Multicentre Cohort in the United Kingdom
Urinary and Sexual Impact of Robotic Radical Prostatectomy: Reporting of Patient-reported Outcome Measures in the First Year after Radical Prostatectomy in a Contemporary Multicentre Cohort in the United Kingdom Open
At 12 months after surgery for prostate cancer, one in ten men reported a moderate or big problem with urine leakage and one in five men reported sufficient erections.
View article: International Variations in Surgical Quality of Care in Men With Prostate Cancer: Results From the TrueNTH Global Registry
International Variations in Surgical Quality of Care in Men With Prostate Cancer: Results From the TrueNTH Global Registry Open
PURPOSE Functional problems such as incontinence and sexual dysfunction after radical prostatectomy (RP) are important outcomes to evaluate surgical quality in prostate cancer (PC) care. Differences in survival after RP between countries a…
View article: PRECISE Version 2: Updated Recommendations for Reporting Prostate Magnetic Resonance Imaging in Patients on Active Surveillance for Prostate Cancer
PRECISE Version 2: Updated Recommendations for Reporting Prostate Magnetic Resonance Imaging in Patients on Active Surveillance for Prostate Cancer Open
The updated PRECISE recommendations reflect expert consensus opinion on minimal standards and reporting criteria for prostate MRI in AS.
View article: How clinically relevant are prostate cancer cell lines? A comprehensive characterisation and multiomics comparison
How clinically relevant are prostate cancer cell lines? A comprehensive characterisation and multiomics comparison Open
Cell line experiments arguably remain the most used tool in preclinical cancer research, despite their limitations. With almost 95% drugs entering human trials failing, and up to 90% preclinical research failing before even being tested in…
View article: Pilot randomized controlled trial of EMBOLDEN: a novel co-designed community-based intervention to enhance mobility in older adults.
Pilot randomized controlled trial of EMBOLDEN: a novel co-designed community-based intervention to enhance mobility in older adults. Open
Introduction: Physical mobility and social participation are essential for maintaining independence and improving quality of life with aging. These are also interrelated, with barriers to mobility leading to social isolation, as well as po…