Phoebe Williams
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View article: Australian Group on Antimicrobial Resistance (AGAR) surveillance outcome programs – bloodstream infections and antimicrobial resistance patterns in Australian children and adolescents, January 2022 – December 2023
Australian Group on Antimicrobial Resistance (AGAR) surveillance outcome programs – bloodstream infections and antimicrobial resistance patterns in Australian children and adolescents, January 2022 – December 2023 Open
Between January 2022 and December 2023, there were 1,827 bloodstream infection (BSI) isolates in 1,745 children and adolescents reported to the Australian Group on Antimicrobial Resistance (AGAR) surveillance outcome programs, with 40% of …
View article: Drug-resistant gram-negative bacterial infections in children in the Oceania region: review of the epidemiology, antimicrobial availability, treatment, clinical trial and pharmacokinetic data, and key evidence gaps
Drug-resistant gram-negative bacterial infections in children in the Oceania region: review of the epidemiology, antimicrobial availability, treatment, clinical trial and pharmacokinetic data, and key evidence gaps Open
Summary: Gram-negative bacterial infections remain a major cause of morbidity and mortality in children and neonates globally, compounded by the rise of antimicrobial resistance. Barriers to paediatric antibiotic licencing lead to reduced …
View article: Pathogen distribution and antimicrobial resistance among neonatal bloodstream infections in Southeast Asia: results from NeoSEAP, a multicentre retrospective study
Pathogen distribution and antimicrobial resistance among neonatal bloodstream infections in Southeast Asia: results from NeoSEAP, a multicentre retrospective study Open
This study was supported by an Australian National Health and Medical Research Council (NHMRC) grant. The NHMRC was not involved in the design or conduct of the research.
View article: The role of serological testing for vaccination with a focus on immunocompromised patients: a synthesis of current evidence
The role of serological testing for vaccination with a focus on immunocompromised patients: a synthesis of current evidence Open
Immunocompromised individuals are at high risk of vaccine-preventable diseases, but typically have impaired immune responses to vaccination and require altered vaccination schedules. Serological testing can inform vaccination decisions in …
View article: Epidemiology of early-onset and late-onset invasive infections in Australian neonates and infants: a retrospective multicentre study
Epidemiology of early-onset and late-onset invasive infections in Australian neonates and infants: a retrospective multicentre study Open
Background There has been little decline in neonatal mortality rates over recent decades, and this is now further challenged by the rising prevalence of antimicrobial resistance. In Australia, the incidence of neonatal sepsis is low on a g…
View article: Epidemiology of sepsis in hospitalised neonates in Indonesia: high burden of multidrug-resistant infections reveals poor coverage provided by recommended antibiotic regimens
Epidemiology of sepsis in hospitalised neonates in Indonesia: high burden of multidrug-resistant infections reveals poor coverage provided by recommended antibiotic regimens Open
Background Neonatal sepsis is a leading cause of child mortality, and this burden is rising secondary to increasing antimicrobial resistance worldwide. There are marked global disparities in the burden of antimicrobial resistance, with Sou…
View article: The challenge of antimicrobial resistance in the Asia-Pacific: a pediatric perspective
The challenge of antimicrobial resistance in the Asia-Pacific: a pediatric perspective Open
Purpose of review The densely populated Asia Pacific region is home to 600 million children, and suffers from a significant burden of morbidity and mortality due to infections associated with antimicrobial resistance (AMR). We aimed to ide…
View article: P-812. Not Little Adults: Key Differences in Antimicrobial Resistance in Australian Bloodstream Isolates between Children and Adults, 2020-2021
P-812. Not Little Adults: Key Differences in Antimicrobial Resistance in Australian Bloodstream Isolates between Children and Adults, 2020-2021 Open
Background The incidence, risks and organisms causing bloodstream infections (BSI) differ between children and adults due to distinct comorbidities, procedures and antibiotic exposures. Age-specific data are required to inform targeted int…
View article: Transgression of planetary boundaries and the effects on child health through an infectious diseases lens
Transgression of planetary boundaries and the effects on child health through an infectious diseases lens Open
Purpose of review Life on earth, as we know it, is changing. The likelihood of more frequent pandemics and disease outbreaks is something that current global healthcare infrastructure is ill equipped to navigate. Human activity is forcing …
View article: A highly selective C–H bond fluorination unlocks conformational reporting in a complex natural product derivative
A highly selective C–H bond fluorination unlocks conformational reporting in a complex natural product derivative Open
In our fluorination of the antibiotic salinomycin and its simple derivatives, a chain of discoveries provided us a unique path to a selective result, unlocking low-noise conformational reporting by 19 F NMR in a widely studied medicinal sc…
View article: Antimicrobial resistance among children in Southeast Asia: a systematic review
Antimicrobial resistance among children in Southeast Asia: a systematic review Open
Introduction There is increasing evidence that antimicrobial resistance (AMR) is responsible for a large burden of morbidity and mortality in children, potentially compounded by reduced efficacy of many commonly recommended empirical antib…
View article: Epidemiology of early- and late-onset serious bacterial infections in Australian neonates and infants: A retrospective multicentre study
Epidemiology of early- and late-onset serious bacterial infections in Australian neonates and infants: A retrospective multicentre study Open
Background There has been little decline in neonatal mortality rates over recent decades, and this is now further challenged by the rising prevalence of antimicrobial resistance (AMR). In Australia, the incidence of neonatal sepsis is low …
View article: The Platform Trial In COVID-19 Vaccine priming and BOOsting (PICOBOO) booster vaccination substudy protocol
The Platform Trial In COVID-19 Vaccine priming and BOOsting (PICOBOO) booster vaccination substudy protocol Open
Background: Coronavirus-2019 (COVID-19) vaccination in Australia commenced in February 2021. The first vaccines recommended for use were AZD1222 and BNT162b2, both delivered as a two-dose primary schedule. In the absence of sustained immun…
View article: Identifying Gaps in the International Consensus Case Definitions for Invasive Aspergillosis: A Review of Clinical Cases Not Meeting These Definitions
Identifying Gaps in the International Consensus Case Definitions for Invasive Aspergillosis: A Review of Clinical Cases Not Meeting These Definitions Open
Background International consensus definitions for invasive aspergillosis (IA) in research are rigorous, yet clinically significant cases are often excluded from clinical studies for not meeting proven/probable IA case definitions. To bett…
View article: Beyond Early- and Late-onset Neonatal Sepsis Definitions: What are the Current Causes of Neonatal Sepsis Globally? A Systematic Review and Meta-analysis of the Evidence
Beyond Early- and Late-onset Neonatal Sepsis Definitions: What are the Current Causes of Neonatal Sepsis Globally? A Systematic Review and Meta-analysis of the Evidence Open
Sepsis remains a leading cause of neonatal mortality, particularly in low- and lower-middle-income countries (LLMIC). In the context of rising antimicrobial resistance, the etiology of neonatal sepsis is evolving, potentially making curren…
View article: Australian Group on Antimicrobial Research surveillance outcome programs – bloodstream infections and antimicrobial resistance patterns from patients less than 18 years of age, January 2020 – December 2021
Australian Group on Antimicrobial Research surveillance outcome programs – bloodstream infections and antimicrobial resistance patterns from patients less than 18 years of age, January 2020 – December 2021 Open
From 1 January 2020 to 31 December 2021, thirty-eight institutions across Australia submitted data to the Australian Group on Antimicrobial Resistance (AGAR) from patients aged < 18 years (AGAR-Kids). Over the two years, 1,679 isolates wer…
View article: Nirsevimab: Alleviating the burden of <scp>RSV</scp> morbidity in young children
Nirsevimab: Alleviating the burden of <span>RSV</span> morbidity in young children Open
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections (LRTIs) and hospital admissions in early childhood. Recent advancements in novel preventive therapies, including extended half‐life monoclon…
View article: Assessing the Impact of Pneumococcal Conjugate Vaccine Immunization Schedule Change From 3+0 to 2+1 in Australian Children: A Retrospective Observational Study
Assessing the Impact of Pneumococcal Conjugate Vaccine Immunization Schedule Change From 3+0 to 2+1 in Australian Children: A Retrospective Observational Study Open
Background In mid-2018, the Australian childhood 13-valent pneumococcal conjugate vaccine schedule changed from 3+0 to 2+1, moving the third dose to 12 months of age, to address increasing breakthrough cases of invasive pneumococcal diseas…
View article: Audit of Non-Pharmacological and Rapid Tranquilisation Practices in Managing Distress Among Older Adults: A Comparative Study in Inverness Hospitals
Audit of Non-Pharmacological and Rapid Tranquilisation Practices in Managing Distress Among Older Adults: A Comparative Study in Inverness Hospitals Open
Aims This audit evaluates the adherence of nursing and medical staff to local protocols for managing distress in older adults (aged >65 years) using non-pharmacological approaches and rapid tranquilisation (RT) in a psychiatric hospital's …
View article: Idiopathic Laryngeal granulomatosis in a teenage girl responsive to Sirolimus
Idiopathic Laryngeal granulomatosis in a teenage girl responsive to Sirolimus Open
Laryngeal granulomatosis may occur in isolation or in conjunction with systemic diseases including ANCA-associated vasculitis and Sarcoidosis. There are a number of case reports of Idiopathic Laryngeal Granulomatosis occurring in teenagers…
View article: Frontispiece: Metal Ion‐Induced Large Fragment Deactivation: A Different Strategy for Site‐Selectivity in a Complex Molecule
Frontispiece: Metal Ion‐Induced Large Fragment Deactivation: A Different Strategy for Site‐Selectivity in a Complex Molecule Open
Synthetic Methods. In their Communication (e202317070), Travis Dudding, Thomas Lectka et al. report a strategy for site-selectivity in complex molecules based on metal ion-induced large fragment deactivation.
View article: Frontispiz: Metal Ion‐Induced Large Fragment Deactivation: A Different Strategy for Site‐Selectivity in a Complex Molecule
Frontispiz: Metal Ion‐Induced Large Fragment Deactivation: A Different Strategy for Site‐Selectivity in a Complex Molecule Open
Synthetic Methods. In their Communication (e202317070), Travis Dudding, Thomas Lectka et al. report a strategy for site-selectivity in complex molecules based on metal ion-induced large fragment deactivation.
View article: Clinical, Genomic, and Immunological Characterization of RSV Surge in Sydney, Australia, 2022
Clinical, Genomic, and Immunological Characterization of RSV Surge in Sydney, Australia, 2022 Open
OBJECTIVES The 2022 seasonal respiratory syncytial virus (RSV) epidemic in Sydney, Australia saw an unprecedented number of RSV detections. We aimed to characterize genomic and immunologic factors associated with the surge in RSV cases. ME…
View article: Metal Ion‐Induced Large Fragment Deactivation: A Different Strategy for Site‐Selectivity in a Complex Molecule
Metal Ion‐Induced Large Fragment Deactivation: A Different Strategy for Site‐Selectivity in a Complex Molecule Open
Complex natural product functionalizations generally involve the use of highly engineered reagents, catalysts, or enzymes to react exclusively at a desired site through lowering of a select transition state energy. In this communication, w…
View article: A single blinded, phase IV, adaptive randomised control trial to evaluate the safety of coadministration of seasonal influenza and COVID-19 vaccines (The FluVID study)
A single blinded, phase IV, adaptive randomised control trial to evaluate the safety of coadministration of seasonal influenza and COVID-19 vaccines (The FluVID study) Open
ACTRN12621001063808.