Charles C.N. Wang
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View article: Development and Validation of a Cross-Device Platform for Anhedonia Trend Visualization by Using Ecological Momentary Assessment and Moving Averages (Part I): Protocol for a Methodological Pilot Study
Development and Validation of a Cross-Device Platform for Anhedonia Trend Visualization by Using Ecological Momentary Assessment and Moving Averages (Part I): Protocol for a Methodological Pilot Study Open
Background Anhedonia is a core symptom of depressive disorders. Although group-level cutoff points for the Snaith–Hamilton Pleasure Scale (SHAPS) are established, real-time, individual-level monitoring remains limited. Ecological momentary…
View article: Zebra-CoT: A Dataset for Interleaved Vision Language Reasoning
Zebra-CoT: A Dataset for Interleaved Vision Language Reasoning Open
Humans often use visual aids, for example diagrams or sketches, when solving complex problems. Training multimodal models to do the same, known as Visual Chain of Thought (Visual CoT), is challenging due to: (1) poor off-the-shelf visual C…
View article: Integrated bioinformatics analysis identifies CHAD association with osteoporosis and in vitro chondrogenic effects of Wogonin
Integrated bioinformatics analysis identifies CHAD association with osteoporosis and in vitro chondrogenic effects of Wogonin Open
Osteoporosis (OP), characterized by reduced bone density and increased fracture risk. Current therapies have limitations due to side effects and variable efficacy, necessitating exploration of novel therapeutic targets and alternatives lik…
View article: Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan
Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan Open
Current genome-wide association studies (GWAS) for kidney function lack ancestral diversity, limiting the applicability to broader populations. The East-Asian population is especially under-represented, despite having the highest global bu…
View article: Tidal Versus Intermittent Peritoneal Dialysis in Chronic Peritoneal Dialysis Patients: Randomized, Open‐Label, Prospective Control Study
Tidal Versus Intermittent Peritoneal Dialysis in Chronic Peritoneal Dialysis Patients: Randomized, Open‐Label, Prospective Control Study Open
Background Tidal peritoneal dialysis (TPD) provides better fluid flow mechanics and is more comfortable for the patient, owing to fewer alarms and less pain during inflow and outflow. The long‐term characteristics of patients with TPD were…
View article: SGLT-2 inhibitors in chronic peritoneal dialysis patients: a follow-up study
SGLT-2 inhibitors in chronic peritoneal dialysis patients: a follow-up study Open
Background Sodium-glucose transporter-2 inhibitors (SGLT-2i) are recommended for use in patients with type 2 diabetes comorbid atherosclerotic cardiovascular disease, heart failure, or chronic kidney disease. Limited reports are currently …
View article: Using Machine Learning and Natural Language Processing in Triage for Prediction of Clinical Disposition in the Emergency Department
Using Machine Learning and Natural Language Processing in Triage for Prediction of Clinical Disposition in the Emergency Department Open
BACKGROUND: Accurate triage is required for efficient allocation of resources and to decrease patients’ length of stay. Triage decisions are often subjective and vary by provider, leading to patients being over-triaged or under-triaged. Th…
View article: SGLT-2 inhibitors in chronic peritoneal dialysis patients: a follow-up study
SGLT-2 inhibitors in chronic peritoneal dialysis patients: a follow-up study Open
Background Sodium-glucose transporter-2 inhibitors (SGLT-2i) are recommended for use in patients with type 2 diabetes comorbid atherosclerotic cardiovascular disease, heart failure or chronic kidney disease. Limited reports are currently a…
View article: Effluent plasminogen activator inhibitor 1 predicts ultrafiltration in incident peritoneal dialysis patients
Effluent plasminogen activator inhibitor 1 predicts ultrafiltration in incident peritoneal dialysis patients Open
Background The peritoneal equilibration test (PET) measures ultrafiltration and small solute clearance in peritoneal dialysis (PD). We aimed to assess if PET and biomarkers predict ultrafiltration in the first two days of PD. Biomarkers in…
View article: Association of epilepsy, anti-epileptic drugs (AEDs), and type 2 diabetes mellitus (T2DM): a population-based cohort retrospective study, impact of AEDs on T2DM-related molecular pathway, and via peroxisome proliferator-activated receptor γ transactivation
Association of epilepsy, anti-epileptic drugs (AEDs), and type 2 diabetes mellitus (T2DM): a population-based cohort retrospective study, impact of AEDs on T2DM-related molecular pathway, and via peroxisome proliferator-activated receptor γ transactivation Open
Introduction A potential association between epilepsy and subsequent type 2 diabetes mellitus (T2DM) has emerged in recent studies. However, the association between epilepsy, anti-epileptic drugs (AEDs), and the risk of T2DM development re…
View article: Cardiothoracic ratio values and trajectories are associated with risk of requiring dialysis and mortality in chronic kidney disease
Cardiothoracic ratio values and trajectories are associated with risk of requiring dialysis and mortality in chronic kidney disease Open
Background The prognostic role of the cardiothoracic ratio (CTR) in chronic kidney disease (CKD) remains undetermined. Methods We conducted a retrospective cohort study of 3117 patients with CKD aged 18–89 years who participated in an Adva…
View article: Prediction of All-Cause Mortality Based on Stress/Rest Myocardial Perfusion Imaging (MPI) Using Deep Learning: A Comparison between Image and Frequency Spectra as Input
Prediction of All-Cause Mortality Based on Stress/Rest Myocardial Perfusion Imaging (MPI) Using Deep Learning: A Comparison between Image and Frequency Spectra as Input Open
Background: Cardiovascular management and risk stratification of patients is an important issue in clinics. Patients who have experienced an adverse cardiac event are concerned for their future and want to know the survival probability. Me…
View article: Machine learning–based triage to identify low-severity patients with a short discharge length of stay in emergency department
Machine learning–based triage to identify low-severity patients with a short discharge length of stay in emergency department Open
Background Overcrowding in emergency departments (ED) is a critical problem worldwide, and streaming can alleviate crowding to improve patient flows. Among triage scales, patients labeled as “triage level 3” or “urgent” generally comprise …
View article: Identification of Key Prognostic Genes of Triple Negative Breast Cancer by LASSO-Based Machine Learning and Bioinformatics Analysis
Identification of Key Prognostic Genes of Triple Negative Breast Cancer by LASSO-Based Machine Learning and Bioinformatics Analysis Open
Improved insight into the molecular mechanisms of triple negative breast cancer (TNBC) is required to predict prognosis and develop a new therapeutic strategy for targeted genes. The aim of this study is to identify key genes which may aff…
View article: Machine learning–based triage to identify low-severity patients with a short discharge length of stay in emergency department
Machine learning–based triage to identify low-severity patients with a short discharge length of stay in emergency department Open
Background: Overcrowding in emergency departments (ED) is a critical problem worldwide, and streaming can alleviate crowding to improve patient flows. Among triage scales, patients labeled as “triage level 3” or “urgent” generally comprise…
View article: Cross-Platform in-silico Analyses Exploring Tumor Immune Microenvironment with Prognostic Value in Triple-Negative Breast Cancer
Cross-Platform in-silico Analyses Exploring Tumor Immune Microenvironment with Prognostic Value in Triple-Negative Breast Cancer Open
Of note, the results of this integrated in silico study can only be generalized to approximately 17% of patients with TNBC, in which infiltrating stromal cells and immune cells play a determinant prognostic role.
View article: Does Weekends Effect Exist in Asia? Analysis of Endovascular Thrombectomyfor Acute Ischemic Stroke in A Medical Center
Does Weekends Effect Exist in Asia? Analysis of Endovascular Thrombectomyfor Acute Ischemic Stroke in A Medical Center Open
Background: Discussing the quality measurements based on interrupted time series in ischemic stroke, delays are often attributed to weekends effect. This study compared the metrics and outcomes of emergent endovascular thrombectomy (EST) d…
View article: LASSO and Bioinformatics Analysis in the Identification of Key Genes for Prognostic Genes of Gynecologic Cancer
LASSO and Bioinformatics Analysis in the Identification of Key Genes for Prognostic Genes of Gynecologic Cancer Open
The aim of this study is to identify potential biomarkers for early diagnosis of gynecologic cancer in order to improve survival. Cervical cancer (CC) and endometrial cancer (EC) are the most common malignant tumors of gynecologic cancer a…
View article: Interleukin-17-based cytokine signaling as a determinant for tumor immune microenvironment with prognostic value in triple-negative breast cancer
Interleukin-17-based cytokine signaling as a determinant for tumor immune microenvironment with prognostic value in triple-negative breast cancer Open
Background: Only a proportion of triple-negative breast cancer (TNBC) is immunotherapy-responsive. We hypothesized that the tumor microenvironment (TME) might influence the outcomes of TNBC and investigated the relevant signaling pathways.…
View article: Application of Deep Learning and Unmanned Aerial Vehicle on Building Maintenance
Application of Deep Learning and Unmanned Aerial Vehicle on Building Maintenance Open
Several natural and human factors are responsible for the defacement of the external walls and tiles of buildings, and the related deterioration can be a public safety hazard. Therefore, active building maintenance and repair processes are…
View article: Repeated centrifuging and washing concentrates bacterial samples in peritoneal dialysis for optimal culture: an original article
Repeated centrifuging and washing concentrates bacterial samples in peritoneal dialysis for optimal culture: an original article Open
Background Bacterial cultures allow the identification of infectious disease pathogens. However, obtaining the results of conventional culture methods is time-consuming, taking at least two days. A more efficient alternative is the use of …
View article: Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis
Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis Open
Bladder cancer is a common malignancy with mechanisms of pathogenesis and progression. This study aimed to identify the prognostic hub genes, which are the central modulators to regulate the progression and proliferation in the specific su…
View article: Identification of Hub Genes Associated With Development of Head and Neck Squamous Cell Carcinoma by Integrated Bioinformatics Analysis
Identification of Hub Genes Associated With Development of Head and Neck Squamous Cell Carcinoma by Integrated Bioinformatics Analysis Open
Improved insight into the molecular mechanisms of head and neck squamous cell carcinoma (HNSCC) is required to predict prognosis and develop a new therapeutic strategy for targeted genes. The aim of this study is to identify significant ge…
View article: Wilforine resensitizes multidrug resistant cancer cells via competitive inhibition of P-glycoprotein
Wilforine resensitizes multidrug resistant cancer cells via competitive inhibition of P-glycoprotein Open
These results suggest a novel future therapeutic strategy for MDR cancer using wilforine as an adjuvant treatment with chemotherapy.