Kyle Steenland
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View article: Baseline exposure–response assessment of metals from dried blood spots and personal household air pollution concentrations among pregnant women in Rwanda: household air pollution intervention network trial
Baseline exposure–response assessment of metals from dried blood spots and personal household air pollution concentrations among pregnant women in Rwanda: household air pollution intervention network trial Open
While associations were not statistically significant, the directionally consistent increases in blood Pb and Cd with increased PM₂.₅ and BC exposures align with existing evidence and underscore the need for continued research and policy a…
View article: Exposure to Household Air Pollution From Biomass Cooking and Severe Pneumonia in Infants
Exposure to Household Air Pollution From Biomass Cooking and Severe Pneumonia in Infants Open
Importance Household air pollution from biomass cooking is considered an important risk factor for child pneumonia. Objective To evaluate the longitudinal association between exposure to particulate matter with a diameter of less than or e…
View article: Household air pollution exposure in adult women is associated with increased carotid intima-media thickness: A cross-sectional study of the Household Air Pollution Intervention Network trial.
Household air pollution exposure in adult women is associated with increased carotid intima-media thickness: A cross-sectional study of the Household Air Pollution Intervention Network trial. Open
In this cross-sectional study, higher personal exposures to PM2.5 and CO were associated with greater mean and maximal CIMT, a well-established biomarker of atherosclerosis, further supporting the association between HAP and cardiovascular…
View article: Liquefied Petroleum Gas or Biomass for Cooking and Effects on Blood Pressure: Results from the Household Air Pollution Intervention Network (HAPIN) Trial
Liquefied Petroleum Gas or Biomass for Cooking and Effects on Blood Pressure: Results from the Household Air Pollution Intervention Network (HAPIN) Trial Open
Background Exposure to household air pollution from burning coal and biomass for cooking is associated with higher blood pressure and other adverse indicators of cardiovascular disease, the leading cause of death worldwide. Evidence demons…
View article: Household air pollution and blood pressure among adult women participants of the Household Air Pollution Intervention Network Trial: An exposure-response analysis
Household air pollution and blood pressure among adult women participants of the Household Air Pollution Intervention Network Trial: An exposure-response analysis Open
The study is registered with ClinicalTrials.gov (NCT02944682) and funded by the U.S. National Institutes of Health (1UM1HL134590) in collaboration with the Bill & Melinda Gates Foundation (OPP1131279).
View article: The role of the components of PM2.5 in the incidence of Alzheimer’s disease and related disorders
The role of the components of PM2.5 in the incidence of Alzheimer’s disease and related disorders Open
We found positive associations between the 15 PM2.5 components and the incidence of dementia and AD. Our findings suggest that reducing PM2.5 emissions from traffic and fossil fuel combustion could help mitigate the growing burden of demen…
View article: Long-term exposure to smoke PM2.5 and COPD caused mortality for elderly people in the contiguous United States
Long-term exposure to smoke PM2.5 and COPD caused mortality for elderly people in the contiguous United States Open
Wildfire events in the US are becoming more frequent and more intensive due to climate change. Fire smoke can significantly contribute to ambient PM2.5 (PM2.5, particles smaller than 2.5 µm in diameter) levels and alter its chemical compos…
View article: Letter: Robins-E risk of bias tool
Letter: Robins-E risk of bias tool Open
Risk-of-bias tools are increasingly used as part of systematic reviews, to help make a uniform evaluation of study quality across a variety of studies (NASEM 2021). Several well-known tools, including OHAT and the Navigation Guide, are use…
View article: Differential DNA methylation in blood as potential mediator of the association between ambient PM<sub>2.5</sub>and cerebrospinal fluid biomarkers of Alzheimer’s disease among a cognitively normal population-based cohort
Differential DNA methylation in blood as potential mediator of the association between ambient PM<sub>2.5</sub>and cerebrospinal fluid biomarkers of Alzheimer’s disease among a cognitively normal population-based cohort Open
Introduction Fine particulate matter (PM 2.5 ) is a known risk factor for Alzheimer’s disease (AD), with emerging evidence linking PM 2.5 exposure to cerebrospinal fluid (CSF) biomarkers in pre-clinical stages. However, the role of DNA met…
View article: Exposure to Ethylene Oxide and Relative Rates of Female Breast Cancer Mortality: 62 Years of Follow-Up in a Large US Occupational Cohort
Exposure to Ethylene Oxide and Relative Rates of Female Breast Cancer Mortality: 62 Years of Follow-Up in a Large US Occupational Cohort Open
This updated analysis of an EtO-exposed worker cohort builds on evidence that EtO is a human breast carcinogen and supports recent exposure reduction proposals. Given the high prevalence of breast cancer, the large number of workers expose…
View article: Associations between Ultrafine Particles and Incident Dementia in Older Adults
Associations between Ultrafine Particles and Incident Dementia in Older Adults Open
Fine particulate matter (PM2.5) is linked to dementia risk, but ultrafine particles (UFPs, 3, respectively) was associated with higher AD (HR: 1.026, 95% CI: 1.014-1.038) and ADRD (HR: 1.016, 95% CI: 1.008-1.023) risks. The association was…
View article: Optimizing Exposure Measures in Large-Scale Household Air Pollution Studies: Results from the Multicountry HAPIN Trial
Optimizing Exposure Measures in Large-Scale Household Air Pollution Studies: Results from the Multicountry HAPIN Trial Open
Repeated measurements of household air pollution may provide better estimates of average exposure but can add to costs and participant burden. In a randomized trial of gas versus biomass cookstoves in four countries, we took supplemental p…
View article: Air Pollution and Cognitive Impairment Among the Chinese Elderly Population: An Analysis of the Chinese Longitudinal Healthy Longevity Survey (CLHLS)
Air Pollution and Cognitive Impairment Among the Chinese Elderly Population: An Analysis of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) Open
Cognitive impairment and dementia have long been recognized as growing public health threats. Studies have found that air pollution is a potential risk factor for dementia, but the literature remains inconclusive. This study aimed to evalu…
View article: Early-life exposure to secondhand smoke and polycyclic aromatic hydrocarbons: associations with epigenetic aging among children
Early-life exposure to secondhand smoke and polycyclic aromatic hydrocarbons: associations with epigenetic aging among children Open
Epigenetic clocks are valuable tools for assessing biological age. Exposure to secondhand smoke (SHS) and polycyclic aromatic hydrocarbons (PAHs) has been linked with epigenetic age deviation (EAD) in adults. However, associations in child…
View article: Exposure Contrasts of Women Aged 40–79 Years during the Household Air Pollution Intervention Network Randomized Controlled Trial
Exposure Contrasts of Women Aged 40–79 Years during the Household Air Pollution Intervention Network Randomized Controlled Trial Open
Exposure to household air pollution has been linked to adverse health outcomes among women aged 40-79. Little is known about how shifting from biomass cooking to a cleaner fuel like liquefied petroleum gas (LPG) could impact exposures for …
View article: The role of the components of PM<sub>2.5</sub>in the incidence of Alzheimer’s disease and related disorders
The role of the components of PM<sub>2.5</sub>in the incidence of Alzheimer’s disease and related disorders Open
Background The associations of PM 2.5 mass and various adverse health outcomes have been widely investigated. However, fewer studies focused on the potential health impacts of PM 2.5 components, especially for dementia and Alzheimer’s dise…
View article: Source-Specific PM <sub>2.5</sub> and Atherosclerotic Cardiovascular Disease Mortality
Source-Specific PM <sub>2.5</sub> and Atherosclerotic Cardiovascular Disease Mortality Open
We found higher ASCVD mortality rate associated with PM2.5, with differential effects across sources. These data highlight the importance of considering local population characteristics and exposure patterns when assessing health risks ass…
View article: A Prospective Analysis of Per- and Polyfluoroalkyl Substances from Early Pregnancy to Delivery in the Atlanta African American Maternal–Child Cohort
A Prospective Analysis of Per- and Polyfluoroalkyl Substances from Early Pregnancy to Delivery in the Atlanta African American Maternal–Child Cohort Open
We found that the concentrations of most PFAS increased during pregnancy, and the magnitude of variability differed by individual PFAS. Future studies are needed to understand the influence of within-person PFAS variability during and afte…
View article: How well does a single blood sample represent long-term exposure for epidemiological studies of PFOA among men in the general population?
How well does a single blood sample represent long-term exposure for epidemiological studies of PFOA among men in the general population? Open
Many epidemiological studies use a single blood sample per participant to assess exposure, but it is unclear how well a single sample represents longer term exposure. We performed a simulation study using summary statistics for repeated se…