Codrin Lungu
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View article: Consumers of illicit tobacco in West Yorkshire (UK): A repeated cross-sectional analysis of novel epidemiological data
Consumers of illicit tobacco in West Yorkshire (UK): A repeated cross-sectional analysis of novel epidemiological data Open
If the consumption of illicit tobacco is to be successfully targeted by public health intervention, a sound understanding of its epidemiological profile is key. Our findings suggest a clear patterning of illicit tobacco consumption along v…
View article: Update in exploring the connection and clinical implications between vitamin D and knee osteoarthritis
Update in exploring the connection and clinical implications between vitamin D and knee osteoarthritis Open
Knee osteoarthritis is a prevalent joint disorder characterized by cartilage degeneration, pain, and impaired physical function. Vitamin D might be implicated in the management of knee osteoarthritis through its effects on bone health, car…
View article: Persistent GDNF Expression 45 Months after Putaminal Infusion of AAV2‐<i>GDNF</i> in a Patient with Parkinson's Disease
Persistent GDNF Expression 45 Months after Putaminal Infusion of AAV2‐<i>GDNF</i> in a Patient with Parkinson's Disease Open
Objective Gene therapy by convection‐enhanced delivery of type 2 adeno‐associated virus‐glial cell derived neurotrophic factor (AAV2‐GDNF) to the bilateral putamina seeks to increase GDNF gene expression and treat Parkinson's disease (PD).…
View article: Objective response to ethanol in essential tremor: results from a standardized ethanol challenge study
Objective response to ethanol in essential tremor: results from a standardized ethanol challenge study Open
Background and Objectives Ethanol has been reported to improve tremor severity in approximately two thirds of patients with essential tremor (ET), but the accuracy of that proportion is not certain and the mechanism of action is unknown. T…
View article: Enrollment of Participants From Marginalized Racial and Ethnic Groups
Enrollment of Participants From Marginalized Racial and Ethnic Groups Open
This study used data from The Safety, Tolerability, and Efficacy Assessment of Isradipine for Parkinson Disease (STEADY-PD III; NCT02168842) and the Study of Urate Elevation in Parkinson's Disease (SURE-PD3; NCT02642393).
View article: The ExTINGUISH Trial: A Phase-2B Randomized Placebo-Controlled Trial of Inebilizumab in Anti-NMDA Receptor Encephalitis
The ExTINGUISH Trial: A Phase-2B Randomized Placebo-Controlled Trial of Inebilizumab in Anti-NMDA Receptor Encephalitis Open
Objective To assess the safety and efficacy of inebilizumab in patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Background The lack of approved therapies for NMDAR encephalitis has led to substantial variability in tr…
View article: Issue Information
Issue Information Open
Movement Disorders Clinical Practice-is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/…
View article: Study in Parkinson’s disease of exercise phase 3 (SPARX3): study protocol for a randomized controlled trial
Study in Parkinson’s disease of exercise phase 3 (SPARX3): study protocol for a randomized controlled trial Open
Background To date, no medication has slowed the progression of Parkinson’s disease (PD). Preclinical, epidemiological, and experimental data on humans all support many benefits of endurance exercise among persons with PD. The key question…
View article: Comparison of Ultrasound and Electrical Stimulation Guidance for Onabotulinum <scp>Toxin‐A</scp> Injections: A Randomized <scp>Crossover</scp> Study
Comparison of Ultrasound and Electrical Stimulation Guidance for Onabotulinum <span>Toxin‐A</span> Injections: A Randomized <span>Crossover</span> Study Open
Background Botulinum neurotoxin (BoNT) injection is an established therapy for limb spasticity and focal limb dystonia. Comparative benefits of injection guidance procedures have not been rigorously studied. Objectives We compared 2 target…
View article: Where Do Parkinson's Disease Patients Look While Walking?
Where Do Parkinson's Disease Patients Look While Walking? Open
Background Parkinson's disease (PD) is associated with gait and visuomotor abnormalities, but it is not clear where PD patients look during ambulation. Objective We sought to characterize the visual areas of interest explored by PD patient…
View article: Time to Publication of Clinical Trials Funded by the National Institute of Neurological Disorders and Stroke
Time to Publication of Clinical Trials Funded by the National Institute of Neurological Disorders and Stroke Open
Many clinical trials are either never published or published after a significant delay. We studied the factors that have influenced the time to publication of clinical trials supported by the National Institute of Neurological Disorders an…
View article: Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression
Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression Open
ClinicalTrials.gov Identifier: NCT02642393.
View article: The Dystonia Coalition: A Multicenter Network for Clinical and Translational Studies
The Dystonia Coalition: A Multicenter Network for Clinical and Translational Studies Open
Dystonia is a movement disorder characterized by sustained or intermittent muscle contractions causing abnormal postures, repetitive movements, or both. Research in dystonia has been challenged by several factors. First, dystonia is uncomm…
View article: Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets
Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets Open
Together, these results suggest that several candidate genes and pathways are associated with the findings observed in PD GWAS studies.
View article: Design of a virtual longitudinal observational study in Parkinson’s disease (AT‐HOME PD)
Design of a virtual longitudinal observational study in Parkinson’s disease (AT‐HOME PD) Open
Objective The expanding power and accessibility of personal technology provide an opportunity to reduce burdens and costs of traditional clinical site‐centric therapeutic trials in Parkinson’s disease and generate novel insights. The value…
View article: Safety and Tolerability of SRX246, a Vasopressin 1a Antagonist, in Irritable Huntington’s Disease Patients—A Randomized Phase 2 Clinical Trial
Safety and Tolerability of SRX246, a Vasopressin 1a Antagonist, in Irritable Huntington’s Disease Patients—A Randomized Phase 2 Clinical Trial Open
SRX246 is a vasopressin (AVP) 1a receptor antagonist that crosses the blood-brain barrier. It reduced impulsive aggression, fear, depression and anxiety in animal models, blocked the actions of intranasal AVP on aggression/fear circuits in…
View article: Assessment of Emergency Department and Inpatient Use and Costs in Adult and Pediatric Functional Neurological Disorders
Assessment of Emergency Department and Inpatient Use and Costs in Adult and Pediatric Functional Neurological Disorders Open
This economic evaluation found that the more than $1.2 billion and increasing annual costs for ED and inpatient care of FNDs were similar to other investigation-intensive and pharmacologically demanding neurological disorders. Unnecessary …
View article: Executive function network’s white matter alterations relate to Parkinson’s disease motor phenotype
Executive function network’s white matter alterations relate to Parkinson’s disease motor phenotype Open
Parkinson’s disease (PD) patients with postural instability and gait disorder phenotype (PIGD) are at high risk of cognitive deficits compared to those with tremor dominant phenotype (TD). Alterations of white matter (WM) integrity can occ…
View article: Quality of life and caregiver burden in familial frontotemporal lobar degeneration: Analyses of symptomatic and asymptomatic individuals within the LEFFTDS cohort
Quality of life and caregiver burden in familial frontotemporal lobar degeneration: Analyses of symptomatic and asymptomatic individuals within the LEFFTDS cohort Open
Objective The Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects evaluates familial frontotemporal lobar degeneration (FTLD) kindreds with MAPT , GRN , or C9orf72 mutations. Objectives were to examine whether health‐relat…
View article: GDNF and Parkinson’s Disease: Where Next? A Summary from a Recent Workshop
GDNF and Parkinson’s Disease: Where Next? A Summary from a Recent Workshop Open
The concept of repairing the brain with growth factors has been pursued for many years in a variety of neurodegenerative diseases including primarily Parkinson's disease (PD) using glial cell line-derived neurotrophic factor (GDNF). This n…