Cody C. Allison
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View article: Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection
Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection Open
View article: Combination antiretroviral therapy and MCL-1 inhibition mitigate HTLV-1 infection in vivo
Combination antiretroviral therapy and MCL-1 inhibition mitigate HTLV-1 infection in vivo Open
This study investigated preventative and therapeutic agents against human T cell lymphotropic virus type-1 subtype-C (HTLV-1c) infection. We established and characterized a humanized mouse model of HTLV-1c infection and identified that HTL…
View article: Efficacy, Safety, and Patient Reported Outcomes of Rhenium-Skin Cancer Therapy for Non-Melanoma Skin Cancer: 1-Year Results from the EPIC-Skin Study
Efficacy, Safety, and Patient Reported Outcomes of Rhenium-Skin Cancer Therapy for Non-Melanoma Skin Cancer: 1-Year Results from the EPIC-Skin Study Open
This 12-month interim analysis of EPIC-Skin indicates rhenium-SCT is an effective and well-tolerated treatment for shallow basal cell carcinoma and SCC lesions, yielding favorable safety, cosmesis, and patient-satisfaction outcomes. These …
View article: A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID
A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID Open
View article: IL-1β drives SARS-CoV-2-induced disease independently of the inflammasome and pyroptosis signalling
IL-1β drives SARS-CoV-2-induced disease independently of the inflammasome and pyroptosis signalling Open
View article: A novel PLpro inhibitor scaffold that protects mice from Long-COVID
A novel PLpro inhibitor scaffold that protects mice from Long-COVID Open
The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 has highlighted the vulnerability of a globally connected population to zoonotic viruses. The only FDA-approved coronavirus antiviral, Paxlovid, targets the essential SARS-CoV-2 ma…
View article: IL-1b drives SARS-CoV-2 disease in vivo, independently of the inflammasome and pyroptotic signalling
IL-1b drives SARS-CoV-2 disease in vivo, independently of the inflammasome and pyroptotic signalling Open
Excessive inflammation and cytokine release are hallmarks of severe COVID-19. Programmed cell death processes can drive inflammation, however, the relevance in the pathogenesis of severe COVID-19 is unclear. Pyroptosis is a pro-inflammator…
View article: CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles
CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles Open
View article: Keratinocyte cancer of the lower limb in the frail elderly – acceptable results for 96 lesions treated with a shortened radiotherapy protocol
Keratinocyte cancer of the lower limb in the frail elderly – acceptable results for 96 lesions treated with a shortened radiotherapy protocol Open
Keratinocyte cancer (KC) is the most prevalent cancer globally, with many patients developing multiple lesions as they age. Surgery is not practical for all patients, particularly older individuals with comorbidities such as vascular insuf…
View article: A reply to ‘Efficacy and safety of widefield radiation therapy for extensive skin field cancerization remains unproven’
A reply to ‘Efficacy and safety of widefield radiation therapy for extensive skin field cancerization remains unproven’ Open
View article: Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo
Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo Open
View article: Efficacy and safety analysis: 24‐month outcomes from a prospective cohort of 106 fields treated with widefield radiation therapy for extensive skin field cancerization, with or without keratinocyte cancers
Efficacy and safety analysis: 24‐month outcomes from a prospective cohort of 106 fields treated with widefield radiation therapy for extensive skin field cancerization, with or without keratinocyte cancers Open
Background Widefield radiation therapy (RT) has emerged as a treatment option for extensive skin field cancerization (ESFC), with or without keratinocyte cancer (KC). Objectives To assess the long‐term efficacy, safety, cosmesis and qualit…
View article: Venetoclax, alone and in combination with the BH3 mimetic S63845, depletes HIV-1 latently infected cells and delays rebound in humanized mice
Venetoclax, alone and in combination with the BH3 mimetic S63845, depletes HIV-1 latently infected cells and delays rebound in humanized mice Open
HIV-1 persists indefinitely in people living with HIV (PLWH) on antiretroviral therapy (ART). If ART is stopped, the virus rapidly rebounds from long-lived latently infected cells. Using a humanized mouse model of HIV-1 infection and CD4
View article: SARS-CoV-2 mouse adaptation selects virulence mutations that cause TNF-driven age-dependent severe disease with human correlates
SARS-CoV-2 mouse adaptation selects virulence mutations that cause TNF-driven age-dependent severe disease with human correlates Open
The diversity of COVID-19 disease in otherwise healthy people, from seemingly asymptomatic infection to severe life-threatening disease, is not clearly understood. We passaged a naturally occurring near-ancestral SARS-CoV-2 variant, capabl…
View article: NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice
NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice Open
The interleukin-1 family members, IL-1β and IL-18, are processed into their biologically active forms by multi-protein complexes, known as inflammasomes. Although the inflammasome pathways that mediate IL-1β processing in myeloid cells hav…
View article: A necroptosis-independent function of RIPK3 promotes immune dysfunction and prevents control of chronic LCMV infection
A necroptosis-independent function of RIPK3 promotes immune dysfunction and prevents control of chronic LCMV infection Open
View article: Epigenetic Silencing of RIPK3 in Hepatocytes Prevents MLKL-mediated Necroptosis From Contributing to Liver Pathologies
Epigenetic Silencing of RIPK3 in Hepatocytes Prevents MLKL-mediated Necroptosis From Contributing to Liver Pathologies Open
View article: Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria
Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria Open
View article: The Association Between Tacrolimus Levels and Hyperkalemia in Allograft Recipients Who Underwent Heart or Lung Transplantation in New Orleans, USA Between 2013 and 2019: A Single-Center Retrospective Study
The Association Between Tacrolimus Levels and Hyperkalemia in Allograft Recipients Who Underwent Heart or Lung Transplantation in New Orleans, USA Between 2013 and 2019: A Single-Center Retrospective Study Open
BACKGROUND Tacrolimus, a calcineurin inhibitor, is the cornerstone of immunosuppressive strategies in transplantation. Other studies have concluded that hyperkalemia correlates with tacrolimus therapy, though the impact is poorly understoo…
View article: Immunopathogenic overlap between COVID-19 and tuberculosis identified from transcriptomic meta-analysis and human macrophage infection
Immunopathogenic overlap between COVID-19 and tuberculosis identified from transcriptomic meta-analysis and human macrophage infection Open
View article: Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation
Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation Open
To control infections phagocytes can directly kill invading microbes. Macrophage‐expressed gene 1 (Mpeg1), a pore‐forming protein sometimes known as perforin‐2, is reported to be essential for bacterial killing following phagocytosis. Mice…
View article: Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain
Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain Open
Potent neutralizing monoclonal antibodies are one of the few agents currently available to treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the viral spike protein can exhibit neutralization resistance…
View article: Macrophage and neutrophil death programs differentially confer resistance to tuberculosis
Macrophage and neutrophil death programs differentially confer resistance to tuberculosis Open
View article: Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice
Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice Open
Significance Neutralizing antibodies are important for immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and as therapeutics for the prevention and treatment of COVID-19. We identified high-affinity nanobodies a…
View article: The role of MKK4 in T‐cell development and immunity to viral infections
The role of MKK4 in T‐cell development and immunity to viral infections Open
The stress‐activated protein kinases (SAPKs)/c‐Jun‐N‐terminal‐kinases (JNK) are members of the mitogen‐activated protein kinase family. These kinases are responsible for transducing cellular signals through a phosphorylation‐dependent sign…
View article: Decision letter: A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants
Decision letter: A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants Open
View article: NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection
NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection Open
The interleukin-1 family members, IL-1β and IL-18, are processed into their biologically active forms by multi-protein complexes, known as inflammasomes. Although the inflammasome pathways that mediate IL-1β processing in myeloid cells hav…
View article: Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2 Open
View article: A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction Open
View article: Mechanism and inhibition of SARS-CoV-2 PLpro
Mechanism and inhibition of SARS-CoV-2 PLpro Open
Coronaviruses, including SARS-CoV-2, encode multifunctional proteases that are essential for viral replication and evasion of host innate immune mechanisms. The papain-like protease PLpro cleaves the viral polyprotein, and reverses inflamm…