Chenshen Huang
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View article: Multimodal Biomarker Analysis of LRRK2-Linked Parkinson’s Disease Across SAA Subtypes
Multimodal Biomarker Analysis of LRRK2-Linked Parkinson’s Disease Across SAA Subtypes Open
The LRRK2+ SAA− cohort of Parkinson’s disease (PD), characterized by the absence of hallmark α-synuclein pathology, remains under-explored. This limits opportunities for early detection and targeted intervention. This study analyzes data f…
View article: A machine learning-derived immune-related prognostic model identifies PLXNA3 as a functional risk gene in colorectal cancer
A machine learning-derived immune-related prognostic model identifies PLXNA3 as a functional risk gene in colorectal cancer Open
Introduction Colorectal Cancer (CRC) remains a leading cause of cancer-related mortality, characterized by substantial interpatient heterogeneity and limited effective prognostic biomarkers. Methods To address this gap, we constructed a ro…
View article: <sup>99</sup>mTc-FAPI SPECT/CT for Evaluation of Myocardial Fibrosis and Cardiac Function in Valvular Heart Disease
<sup>99</sup>mTc-FAPI SPECT/CT for Evaluation of Myocardial Fibrosis and Cardiac Function in Valvular Heart Disease Open
Background Active myocardial fibrosis plays a pivotal role in valvular heart disease (VHD) progression. While conventional imaging modalities primarily detect established fibrosis, the detection of active fibroblast activation remains chal…
View article: The potential of the serum uric acid to high-density lipoprotein cholesterol ratio as a predictive biomarker of diabetes risk: a study based on NHANES 2005–2018
The potential of the serum uric acid to high-density lipoprotein cholesterol ratio as a predictive biomarker of diabetes risk: a study based on NHANES 2005–2018 Open
Previous studies have indicated an association between UHR and diabetes risk, but evidence from large-scale and diverse populations remains limited. This study aims to verify UHR’s independent role in diabetes risk prediction in a large sa…
View article: FFAR2 expressing myeloid-derived suppressor cells drive cancer immunoevasion
FFAR2 expressing myeloid-derived suppressor cells drive cancer immunoevasion Open
Background Emerging evidences suggest that aberrant metabolites contributes to the immunosuppressive microenvironment that leads to cancer immune evasion. Among tumor immunosuppressive cells, myeloid-derived suppressor cells (MDSCs) are pa…
View article: Capture of transcriptomic events in Stomach Adenocarcinoma integrating alignment-based and alignment-free protocols
Capture of transcriptomic events in Stomach Adenocarcinoma integrating alignment-based and alignment-free protocols Open
Background Transcriptome expression variations and abnormalities in peptides and proteins play a crucial role in phenotypic differences. RNA-seq data provides valuable insights for identifying disease-causing mutations. However, traditiona…
View article: Tranditional Roux-en-Y vs Uncut Roux-en-Y in Laparoscopic Distal Gastrectomy: a Randomized Controlled Study
Tranditional Roux-en-Y vs Uncut Roux-en-Y in Laparoscopic Distal Gastrectomy: a Randomized Controlled Study Open
Compared with traditional Roux-en-Y anastomosis, due to the high recanalization rate, the URY group developed more severe gastrointestinal symptoms, the incidence of bile reflux and the grade of residual gastritis increased and the inciden…
View article: Identification of S1PR4 as an immune modulator for favourable prognosis in HNSCC through unbiased machine learning
Identification of S1PR4 as an immune modulator for favourable prognosis in HNSCC through unbiased machine learning Open
As the largest family of membrane proteins, G protein-coupled receptors (GPCRs) are the most prominent family of pharmacological targets. However, only a few GPCRs have been well-defined in terms of their physiological and pathological fun…
View article: Impact of endoscopic metallic stent placement and emergency surgery on detection of viable circulating tumor cells for acute malignant left-sided colonic obstruction
Impact of endoscopic metallic stent placement and emergency surgery on detection of viable circulating tumor cells for acute malignant left-sided colonic obstruction Open
Background: Self-expanding metal stents (SEMS) served as a bridge to surgery (BTS). However, this method may be associated with worse long-term prognosis and relapse of CRC patients. Therefore, we attempted to clarify this in the angle of …
View article: Novel insight on predicting prognosis of gastric cancer based on inflammation
Novel insight on predicting prognosis of gastric cancer based on inflammation Open
We established and validated an inflammation-related prognostic model that predicts immune escape and patient prognosis in GC. Our model is expected to improve clinical outcomes by facilitating clinical decision making and the development …
View article: Multi-omics analysis for potential inflammation-related genes involved in tumour immune evasion via extended application of epigenetic data
Multi-omics analysis for potential inflammation-related genes involved in tumour immune evasion via extended application of epigenetic data Open
Accumulating evidence suggests that inflammation-related genes may play key roles in tumour immune evasion. Programmed cell death ligand 1 (PD-L1) is an important immune checkpoint involved in mediating anti-tumour immunity. We performed m…
View article: Neuroendocrine Regulation of Stress‐Induced T Cell Dysfunction during Lung Cancer Immunosurveillance via the Kisspeptin/GPR54 Signaling Pathway
Neuroendocrine Regulation of Stress‐Induced T Cell Dysfunction during Lung Cancer Immunosurveillance via the Kisspeptin/GPR54 Signaling Pathway Open
Emerging evidence suggests that physiological distress is highly correlated with cancer incidence and mortality. However, the mechanisms underlying psychological challenges‐mediated tumor immune evasion are not systematically explored. Her…
View article: Multi-Omics Analysis for Transcriptional Regulation of Immune-Related Targets Using Epigenetic Data: A New Research Direction
Multi-Omics Analysis for Transcriptional Regulation of Immune-Related Targets Using Epigenetic Data: A New Research Direction Open
Background Currently, a comprehensive method for exploration of transcriptional regulation has not been well established. We explored a novel pipeline to analyze transcriptional regulation using co-analysis of RNA sequencing (RNA-seq), ass…
View article: Supplemental Table S2 | List of 1639 TFs from Human Transcription Factors database. from Multi-omics analysis for potential inflammation-related genes involved in tumour immune evasion via extended application of epigenetic data
Supplemental Table S2 | List of 1639 TFs from Human Transcription Factors database. from Multi-omics analysis for potential inflammation-related genes involved in tumour immune evasion via extended application of epigenetic data Open
Supplemental Table S2 | List of 1639 TFs from Human Transcription Factors database.
View article: Multi-omics analysis for potential inflammation-related genes involved in tumor immune evasion via extended application of epigenetic data
Multi-omics analysis for potential inflammation-related genes involved in tumor immune evasion via extended application of epigenetic data Open
Background Accumulating evidence suggests that inflammation-related genes may play key roles in tumor immune evasion. Programmed cell death ligand 1 (PD-L1) is an important immune checkpoint involved in mediating antitumor immunity. We per…
View article: Recanalization in Uncut Roux-en-Y Reconstruction: An Animal Experiment and a Clinical Study
Recanalization in Uncut Roux-en-Y Reconstruction: An Animal Experiment and a Clinical Study Open
Background: Because of the challenge of jejunal closure recanalization, uncut Roux-en-Y reconstruction remains controversial. This study aimed to investigate the incidence of recanalization after uncut Roux-en-Y reconstruction in pigs and …
View article: PLXNC1: A Novel Potential Immune-Related Target for Stomach Adenocarcinoma
PLXNC1: A Novel Potential Immune-Related Target for Stomach Adenocarcinoma Open
Background Gastric cancer is associated with tumor microenvironment and chronic inflammation, but the underlying tumor-promoting mechanisms still remain unknown. Methods The ATAC-seq was used to identify genes with chromatin accessibilitie…
View article: Sclerosing encapsulating peritonitis as a rare cause of intestinal obstruction after the treatment of peritoneal mesothelioma: a case report and review of the literature
Sclerosing encapsulating peritonitis as a rare cause of intestinal obstruction after the treatment of peritoneal mesothelioma: a case report and review of the literature Open
Sclerosing encapsulating peritonitis (SEP) is a rare cause of intestinal obstruction that is characterized by a thick greyish-white fibrotic membrane encasing the small bowel. The clinical features are typically nonspecific, and they occas…
View article: Chromatin Accessibility Regulates Gene Expression and Correlates With Tumor-Infiltrating Immune Cells in Gastric Adenocarcinoma
Chromatin Accessibility Regulates Gene Expression and Correlates With Tumor-Infiltrating Immune Cells in Gastric Adenocarcinoma Open
Background We explored key molecules affecting the prognosis of gastric adenocarcinoma (STAD) using co-analysis of chromatin accessibility (ATAC-seq), mRNA expression (RNA-seq), and overall survival. Methods We used the assay for transposa…
View article: Propensity Score-Matched Comparison of Stenting as Bridge to Surgery and Emergency Surgery for Acute Malignant Left-Sided Colonic Obstruction
Propensity Score-Matched Comparison of Stenting as Bridge to Surgery and Emergency Surgery for Acute Malignant Left-Sided Colonic Obstruction Open
PurposeBridge to elective surgery (BTS) using self-expanding metal stents (SEMS) is a common alternative to emergency surgery (ES) for acute malignant left-sided colonic obstruction (AMLCO). However, the study regarding long-term impact of…
View article: Prognostic role of platelet to lymphocyte ratio in hepatocellular carcinoma: a systematic review and meta-analysis
Prognostic role of platelet to lymphocyte ratio in hepatocellular carcinoma: a systematic review and meta-analysis Open
The study revealed that high PLR is an unfavorable predictor of OS in patients with HCC, and high PLR is a promising prognostic biomarker for HCC, especially for patients in Asia.
View article: Prognostic role of podocalyxin-like protein expression in various cancers: A systematic review and meta-analysis
Prognostic role of podocalyxin-like protein expression in various cancers: A systematic review and meta-analysis Open
Several studies were conducted to explore the prognostic significance of podocalyxin-like protein (PODXL) expression in various cancers, with contradictory. This study aims to summarize the prognostic significance of PODXL expression in ca…