Cody L. Stothers
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View article: Immunoresponsive gene 1 facilitates TLR4 agonist-induced augmentation of innate antimicrobial immunity
Immunoresponsive gene 1 facilitates TLR4 agonist-induced augmentation of innate antimicrobial immunity Open
Treatment with the toll-like receptor 4 agonist monophosphoryl lipid A conditions innate immunocytes to respond robustly to subsequent infection, a phenotype termed innate immune memory. Our published studies show that metabolic reprogramm…
View article: Bacteria- and fungus-derived PAMPs induce innate immune memory via similar functional, metabolic, and transcriptional adaptations
Bacteria- and fungus-derived PAMPs induce innate immune memory via similar functional, metabolic, and transcriptional adaptations Open
Exposure to pathogen-associated molecular patterns (PAMPs) induces an augmented, broad-spectrum antimicrobial response to subsequent infection, a phenomenon termed innate immune memory. This study examined the effects of treatment with β-g…
View article: MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages
MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages Open
Immunocompromised populations are highly vulnerable to developing life-threatening infections. Strategies to protect patients with weak immune responses are urgently needed. Employing trained immunity, whereby innate leukocytes undergo rep…
View article: Loss of Sirtuin 1 (SIRT1) potentiates endothelial dysfunction via impaired glycolysis during infectious challenge
Loss of Sirtuin 1 (SIRT1) potentiates endothelial dysfunction via impaired glycolysis during infectious challenge Open
Sepsis is an exaggerated host response to infection that despite advances in early recognition and intervention, remains a common cause of morbidity and mortality.1, 2 The pathophysiology is related to global inflammation and cytokinemia d…
View article: MyD88-Dependent Signaling Drives Toll-Like Receptor-Induced Trained Immunity in Macrophages
MyD88-Dependent Signaling Drives Toll-Like Receptor-Induced Trained Immunity in Macrophages Open
Immunocompromised populations are highly vulnerable to developing life-threatening infections. Strategies to protect patients with weak immune responses are urgently needed. Employing trained immunity, whereby innate leukocytes undergo rep…
View article: Innate Immune Memory and the Host Response to Infection
Innate Immune Memory and the Host Response to Infection Open
Unlike the adaptive immune system, the innate immune system has classically been characterized as being devoid of memory functions. However, recent research shows that innate myeloid and lymphoid cells have the ability to retain memory of …
View article: β-Glucan Induces Distinct and Protective Innate Immune Memory in Differentiated Macrophages
β-Glucan Induces Distinct and Protective Innate Immune Memory in Differentiated Macrophages Open
Bacterial infections are a common and deadly threat to vulnerable patients. Alternative strategies to fight infection are needed. β-Glucan, an immunomodulator derived from the fungal cell wall, provokes resistance to infection by inducing …
View article: The Metabolic Basis of Immune Dysfunction Following Sepsis and Trauma
The Metabolic Basis of Immune Dysfunction Following Sepsis and Trauma Open
Critically ill, severely injured and high-risk surgical patients are vulnerable to secondary infections during hospitalization and after hospital discharge. Studies show that the mitochondrial function and oxidative metabolism of monocytes…
View article: Immunobiology and application of toll-like receptor 4 agonists to augment host resistance to infection
Immunobiology and application of toll-like receptor 4 agonists to augment host resistance to infection Open
View article: Radioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases After Initial Peptide Receptor Radionuclide Therapy
Radioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases After Initial Peptide Receptor Radionuclide Therapy Open
Purpose Peptide receptor radionuclide therapy (PRRT) and radioembolization are increasingly used in neuroendocrine neoplasms patients. However, concerns have been raised on cumulative hepatotoxicity. The aim of this sub-analysis was to inv…
View article: Phosphorylated Hexa-Acyl Disaccharides Augment Host Resistance Against Common Nosocomial Pathogens
Phosphorylated Hexa-Acyl Disaccharides Augment Host Resistance Against Common Nosocomial Pathogens Open
Objectives: To determine whether synthetic phosphorylated hexa-acyl disaccharides provide antimicrobial protection in clinically relevant models of bacterial infection. Design: Laboratory study. Setting: University laboratory. Subjects: BA…
View article: Monophosphoryl Lipid a Attenuates Multiorgan Dysfunction During Post-Burn Pseudomonas Aeruginosa Pneumonia in Sheep
Monophosphoryl Lipid a Attenuates Multiorgan Dysfunction During Post-Burn Pseudomonas Aeruginosa Pneumonia in Sheep Open
Background: Monophosphoryl lipid A (MPLA) is a TLR4 agonist that has potent immunomodulatory properties and modulates innate immune function to improve host resistance to infection with common nosocomial pathogens in mice. The goal of this…
View article: The TLR4 Agonist Monophosphoryl Lipid A Drives Broad Resistance to Infection via Dynamic Reprogramming of Macrophage Metabolism
The TLR4 Agonist Monophosphoryl Lipid A Drives Broad Resistance to Infection via Dynamic Reprogramming of Macrophage Metabolism Open
Monophosphoryl lipid A (MPLA) is a clinically used TLR4 agonist that has been found to drive nonspecific resistance to infection for up to 2 wk. However, the molecular mechanisms conferring protection are not well understood. In this study…
View article: Extracellular chloride signals collagen IV network assembly during basement membrane formation
Extracellular chloride signals collagen IV network assembly during basement membrane formation Open
Basement membranes are defining features of the cellular microenvironment; however, little is known regarding their assembly outside cells. We report that extracellular Cl− ions signal the assembly of collagen IV networks outside cells by …