Cole Wayant
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View article: An evaluation of selinexor’s clinical trial portfolio: a cross-sectional study
An evaluation of selinexor’s clinical trial portfolio: a cross-sectional study Open
Background: Cancer drug development is a complex and costly process. Selinexor is a drug that received accelerated approval as a new treatment for relapsed or refractory diffuse-large B-cell lymphoma and multiple myeloma. Despite initially…
View article: Prevalence of Adverse Event Reporting in Adolescents and Young Adults Enrolled in Cancer Clinical Trials
Prevalence of Adverse Event Reporting in Adolescents and Young Adults Enrolled in Cancer Clinical Trials Open
Adverse event reporting for AYAs with cancer was poor in a new study by @ColeWayant, et al.
View article: A Reliability Generalization Meta-Analysis of 17 Patient-Reported Outcome Measures for Positive Psychosocial Constructs in Children, Adolescents, and Young Adults with Cancer
A Reliability Generalization Meta-Analysis of 17 Patient-Reported Outcome Measures for Positive Psychosocial Constructs in Children, Adolescents, and Young Adults with Cancer Open
Introduction: Children, adolescents, and young adults (AYAs) with cancer are a special population who are subjected to a number of unique challenges, stressors, and barriers to high-quality psychological care. In a recent sys…
View article: Evaluation of Patient-Reported Outcome Measures of Positive Psychosocial Constructs in Children and Adolescent/Young Adults with Cancer: A Systematic Review of Measurement Properties
Evaluation of Patient-Reported Outcome Measures of Positive Psychosocial Constructs in Children and Adolescent/Young Adults with Cancer: A Systematic Review of Measurement Properties Open
Introduction: Children, adolescents, and young adults with cancer are a vulnerable population in whom improvements in psycho-oncology care would be valuable. We previously published a scoping review exploring what is known ab…
View article: Rigor and reproducibility of cancer medicine evidence
Rigor and reproducibility of cancer medicine evidence Open
The burden of cancer in the United States and abroad is comprised of significant morbidity, mortality, and psychological or financial harms. There remains a concern that the influence of published research is not maximized because of bias,…
View article: STARD Adherence in an Interventional Radiology Guideline for Diagnostic Arteriography
STARD Adherence in an Interventional Radiology Guideline for Diagnostic Arteriography Open
Objective: To assess the quality of reporting in diagnostic accuracy studies (DAS) referenced by the Quality Improvement Guidelines for Diagnostic Arteriography and their adherence to the Standards for Reporting of Diagnostic Accura…
View article: Identification of Evidence for Key Positive Psychological Constructs in Pediatric and Adolescent/Young Adult Patients with Cancer: A Scoping Review
Identification of Evidence for Key Positive Psychological Constructs in Pediatric and Adolescent/Young Adult Patients with Cancer: A Scoping Review Open
Introduction: Children and adolescents/young adults (AYAs) with cancer are a vulnerable population susceptible to numerous late effects, such as fatigue and depression, which may diminish their long-term psychological, physic…
View article: Citation bias in otolaryngology systematic reviews
Citation bias in otolaryngology systematic reviews Open
Objective: Reproducibility of systemic reviews (SRs) can be hindered by the presence of citation bias. Citation bias may occur when authors of SRs conduct hand-searches of included study reference lists to identify additional studies. Such…
View article: Reducing bias and improving transparency in medical research: a critical overview of the problems, progress and suggested next steps
Reducing bias and improving transparency in medical research: a critical overview of the problems, progress and suggested next steps Open
In recent years there has been increasing awareness of problems that have undermined trust in medical research. This review outlines some of the most important issues including research culture, reporting biases, and statistical and method…
View article: Evaluation of Financial Conflicts of Interests Among Congress of Neurological Surgeon Guideline Authors
Evaluation of Financial Conflicts of Interests Among Congress of Neurological Surgeon Guideline Authors Open
This study examines payments from medical device and pharmaceutical companies compiled in the Open Payments Database to physician-authors of the Congress of Neurological Surgery’s clinical practice guidelines.
View article: Identification of key positive psychosocial constructs in pediatric and adolescent/young adult patients with cancer: a scoping review.
Identification of key positive psychosocial constructs in pediatric and adolescent/young adult patients with cancer: a scoping review. Open
Introduction. Children and adolescents/young adults (AYAs) with cancer are a vulnerable population susceptible to numerous late effects, such as fatigue and depression, that may diminish their long-term psychosocial, physical, spiritual, a…
View article: Evaluation of “Spin” in the Abstracts of Randomized Controlled Trial Reports in Cardiology
Evaluation of “Spin” in the Abstracts of Randomized Controlled Trial Reports in Cardiology Open
Context The misrepresentation and distortion of research findings, known as “spin,” has been shown to affect clinical decision making. Spin has been found in randomized controlled trials (RCTs) published in various fields of medicine. Obje…
View article: Comparison of FDA accelerated vs regular pathway approvals for lung cancer treatments between 2006 and 2018
Comparison of FDA accelerated vs regular pathway approvals for lung cancer treatments between 2006 and 2018 Open
Regulatory agencies around the world have been using flexible requirements for approval of new drugs, especially for cancer drugs. The US Food and Drug Administration (FDA) is mostly the first agency to approve new drugs worldwide, mainly …
View article: Evaluation of Selective Outcome Reporting Bias in Efficacy Endpoints in Print and Television Advertisements for Oncology Drugs
Evaluation of Selective Outcome Reporting Bias in Efficacy Endpoints in Print and Television Advertisements for Oncology Drugs Open
View article: Reducing bias and improving transparency in biomedical and health research: A critical overview of the problems, progress so far and suggested next steps
Reducing bias and improving transparency in biomedical and health research: A critical overview of the problems, progress so far and suggested next steps Open
In recent years there has been increasing awareness about problems which have undermined trust in science generally. This review outlines some of the most important issues facing medical research including research culture, lack of transpa…
View article: Reducing bias and improving transparency in biomedical and health research: A critical overview of the problems, progress so far and suggested next steps
Reducing bias and improving transparency in biomedical and health research: A critical overview of the problems, progress so far and suggested next steps Open
In recent years there has been increasing awareness about problems which have undermined trust in science generally. This review outlines some of the most important issues facing medical research including research culture, lack of transpa…
View article: Characteristics and conflicts of interests of public speakers at the Psychopharmacologic Drug and Advisory Committee meetings regarding psychiatric drugs
Characteristics and conflicts of interests of public speakers at the Psychopharmacologic Drug and Advisory Committee meetings regarding psychiatric drugs Open
The Psychopharmacologic Drug Advisory Committee (PDAC) is one of 33 advisory committees of the Food and Drug Administration (FDA). During committee meetings, an open public hearing takes place where speakers provide testimonies about the d…
View article: Risk of Bias and Quality of Reporting in Colon and Rectal Cancer Systematic Reviews Cited by National Comprehensive Cancer Network Guidelines
Risk of Bias and Quality of Reporting in Colon and Rectal Cancer Systematic Reviews Cited by National Comprehensive Cancer Network Guidelines Open
View article: Do oncology researchers adhere to reproducible and transparent principles? A cross-sectional survey of published oncology literature
Do oncology researchers adhere to reproducible and transparent principles? A cross-sectional survey of published oncology literature Open
Objectives As much as 50%–90% of research is estimated to be irreproducible, costing upwards of $28 billion in USA alone. Reproducible research practices are essential to improving the reproducibility and transparency of biomedical researc…
View article: On reporting and interpreting statistical significance and p values in medical research
On reporting and interpreting statistical significance and p values in medical research Open
Recent proposals to change the p value threshold from 0.05 to 0.005 or to retire statistical significance altogether have garnered much criticism and debate.1 2 As of the writing of our manuscript, the proposal to eliminate statistical sig…
View article: Challenges facing early-career and mid-career researchers: potential solutions to safeguard the future of evidence-based medicine
Challenges facing early-career and mid-career researchers: potential solutions to safeguard the future of evidence-based medicine Open
The challenges facing the evidence-based medicine (EBM) movement are well documented.1 2 Yet, the problems facing early-career and mid-career researchers (EMCRs) working in the ecosystem of EBM have not been articulated. The coming togethe…
View article: Evaluation of Reproducible Research Practices in Oncology Systematic Reviews With Meta-analyses Referenced by National Comprehensive Cancer Network Guidelines
Evaluation of Reproducible Research Practices in Oncology Systematic Reviews With Meta-analyses Referenced by National Comprehensive Cancer Network Guidelines Open
More reproducible research practices are needed in oncology meta-analyses, as suggested by those that are cited by the NCCN. Reporting meta-analyses in forest plots and requirements for full data sharing are recommended.
View article: Using the CONSORT statement to evaluate the completeness of reporting of addiction randomised trials: a cross-sectional review
Using the CONSORT statement to evaluate the completeness of reporting of addiction randomised trials: a cross-sectional review Open
Objectives Evaluate the completeness of reporting of addiction randomised controlled trials (RCTs) using the Consolidated Standards of Reporting Trials (CONSORT) statement. Setting Not applicable. Participants RCTs identified using a PubMe…
View article: Evaluation of spin in abstracts of papers in psychiatry and psychology journals
Evaluation of spin in abstracts of papers in psychiatry and psychology journals Open
We have identified ‘spin’ in abstracts of randomised controlled trials (RCTs) with nonsignificant primary endpoints in psychiatry and psychology journals. This is a cross-sectional review of clinical trials with nonsignificant primary endp…
View article: Reproducibility and transparency characteristics of oncology research evidence
Reproducibility and transparency characteristics of oncology research evidence Open
Introduction As much as 50%-90% of research is estimated to be irreproducible, costing upwards of $28 billion in the United States alone. Reproducible research practices are essential to improving the reproducibility and transparency of bi…
View article: 3 A review of the magnitude of financial relationships with industry and disclosure practices among clinical practice guideline authors
3 A review of the magnitude of financial relationships with industry and disclosure practices among clinical practice guideline authors Open
Objectives Financial conflicts of interest (FCOI) with the pharmaceutical industry are associated with a sizeable, unidirectional, reproducible effect in favor of 'positive' research findings, per a recent Cochrane systematic review. In th…
View article: The Fragility Index in a Cohort of HIV/AIDS Randomized Controlled Trials
The Fragility Index in a Cohort of HIV/AIDS Randomized Controlled Trials Open
View article: An Evaluation of Publication Bias in High-Impact Orthopaedic Literature
An Evaluation of Publication Bias in High-Impact Orthopaedic Literature Open
Background: Statistical analysis of systematic reviews allows the results of previous studies to be combined and synthesized to assess the overall health effect of the intervention in question. Systematic reviews can also be used to guide …
View article: Noninferiority Trials - Oncology
Noninferiority Trials - Oncology Open
The primary outcome of this investigation is the quality of reporting, design, and interpretation of oncology noninferiority trials of anti-tumor interventions. We will further calculate the percent of preserved effect that for each new tr…
View article: Presence of ‘spin’ in the abstracts and titles of anaesthesiology randomised controlled trials
Presence of ‘spin’ in the abstracts and titles of anaesthesiology randomised controlled trials Open