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View article: <i>Bartonella</i> endocarditis: a complex diagnosis of blood culture-negative endocarditis in an endemic region of Africa
<i>Bartonella</i> endocarditis: a complex diagnosis of blood culture-negative endocarditis in an endemic region of Africa Open
Introduction Bartonella species are an important emerging cause of blood culture-negative endocarditis (BCNE). The diagnosis requires serology by indirect immunofluorescence assay (IFA) and PCR testing on blood and/or tissue. Access to the…
View article: Echocardiographic features of infective endocarditis in South Africa: A prospective cohort study
Echocardiographic features of infective endocarditis in South Africa: A prospective cohort study Open
Background: Historically, infective endocarditis(IE) in South Africa was associated with the viridans group of streptococci affecting patients with underlying rheumatic heart disease(RHD). A changing IE bacteriological profile raises the q…
View article: Comparison of commercial assays and two-step approach to detect Clostridioides difficile in South Africa
Comparison of commercial assays and two-step approach to detect Clostridioides difficile in South Africa Open
Background: Clostridioides difficile is the number one cause of hospital-acquired diarrhoea. Accurate diagnosis of C. difficile is of utmost importance as it guides patient management and infection control practices. Studies evaluating the…
View article: Early surgery determines prognosis in patients with infective endocarditis: outcome in patients managed by an Endocarditis Team—a prospective cohort study
Early surgery determines prognosis in patients with infective endocarditis: outcome in patients managed by an Endocarditis Team—a prospective cohort study Open
We have observed a reduction in the 6-month mortality rate in patients with IE following the establishment of an Endocarditis Team, adhering to a set protocol for organism detection and favouring early repair or reconstruction surgery. Pat…
View article: Modified Duke/European Society of Cardiology 2015 clinical criteria for infective endocarditis: time for an update?
Modified Duke/European Society of Cardiology 2015 clinical criteria for infective endocarditis: time for an update? Open
Background The diagnosis of infective endocarditis (IE) is based on the modified Duke/European Society of Cardiology (ESC) 2015 clinical criteria. The sensitivity of the criteria is unknown in South Africa, but high rates of blood culture …
View article: Echocardiographic features of infective endocarditis in South Africa: A prospective cohort study
Echocardiographic features of infective endocarditis in South Africa: A prospective cohort study Open
Background. Historically, infective endocarditis (IE) in South Africa (SA) was associated with the viridans group of streptococci affecting patients with underlying rheumatic heart disease (RHD). A changing IE bacteriological profile raise…
View article: Causes of infective endocarditis in the Western Cape, South Africa: a prospective cohort study using a set protocol for organism detection and central decision making by an endocarditis team
Causes of infective endocarditis in the Western Cape, South Africa: a prospective cohort study using a set protocol for organism detection and central decision making by an endocarditis team Open
Background Blood culture negative infective endocarditis (BCNIE) poses both a diagnostic and therapeutic challenge. High rates of BCNIE reported in South Africa have been attributed to antibiotic use prior to blood culture sampling. Object…
View article: Exudative pharyngitis and Corynebacterium pseudodiphtheriticum: A case report and review of the literature
Exudative pharyngitis and Corynebacterium pseudodiphtheriticum: A case report and review of the literature Open
Corynebacterium pseudodiphtheriticum is an established member of the normal flora of the respiratory tract. This organism is an emerging cause of respiratory tract infection, as well as infection of the skin and skin structures, urinary tr…
View article: Bartonella Species as a Cause of Culture-negative Endocarditis in South Africa&nbsp;
Bartonella Species as a Cause of Culture-negative Endocarditis in South Africa Open
Background: Previous reports have highlighted the high prevalence of blood culture negative endocarditis (BCNE) in South Africa.Methods: The Tygerberg Endocarditis cohort (TEC) study is a prospective cohort study of patients with confirmed…
View article: Early Surgery Determines Prognosis in Patients with IE: Outcome of Patients Managed by an Endocarditis Team - a Prospective Cohort Study
Early Surgery Determines Prognosis in Patients with IE: Outcome of Patients Managed by an Endocarditis Team - a Prospective Cohort Study Open
View article: New ecosystems in the deep subsurface follow the flow of water driven by geological activity
New ecosystems in the deep subsurface follow the flow of water driven by geological activity Open
Eukarya have been discovered in the deep subsurface at several locations in South Africa, but how organisms reach the subsurface remains unknown. We studied river-subsurface fissure water systems and identified Eukarya from a river that ar…
View article: Eukaryotic opportunists dominate the deep-subsurface biosphere in South Africa
Eukaryotic opportunists dominate the deep-subsurface biosphere in South Africa Open
Following the discovery of the first Eukarya in the deep subsurface, intense interest has developed to understand the diversity of eukaryotes living in these extreme environments. We identified that Platyhelminthes, Rotifera, Annelida and …