Colin D. Kay
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View article: Effect of age and sex on the urinary elimination of a single dose of mixed flavonoids: results from a single-arm intervention in healthy United Kingdom adults
Effect of age and sex on the urinary elimination of a single dose of mixed flavonoids: results from a single-arm intervention in healthy United Kingdom adults Open
View article: Beyond the Known Metabolome: Predictive Strategies for Dark Matter Discovery
Beyond the Known Metabolome: Predictive Strategies for Dark Matter Discovery Open
View article: Prenatal Polyphenol Intake During Late Pregnancy Is Positively Associated With Academic and IQ Scores in School-Age Children
Prenatal Polyphenol Intake During Late Pregnancy Is Positively Associated With Academic and IQ Scores in School-Age Children Open
View article: Comparison of the capillary and venous blood plasma lipidomes: validation of self-collected blood for plasma lipidomics
Comparison of the capillary and venous blood plasma lipidomes: validation of self-collected blood for plasma lipidomics Open
Venipuncture of the upper extremities is commonly used to collect blood for plasma lipidomics. However, self-administered blood collection devices such as the Tasso+™ system for capillary blood sampling and plasma separation are convenient…
View article: Identification and functional characterization of BAHD acyltransferases associated with anthocyanin acylation in blueberry
Identification and functional characterization of BAHD acyltransferases associated with anthocyanin acylation in blueberry Open
Blueberry is promoted as a super food with several health properties derived from chlorogenic acid and anthocyanin. Previous studies indicated that anthocyanin acylation and the content of chlorogenic acid could affect their level of absor…
View article: Polyphenol metabolites in human milk: Potential role in support of healthy infant development, a narrative review
Polyphenol metabolites in human milk: Potential role in support of healthy infant development, a narrative review Open
Polyphenols are a broad class of phytochemicals derived from healthy diets rich in fruits, vegetables, and whole grains. Due to emerging evidence linking healthy dietary patterns to maternal and child health benefits, there is increasing i…
View article: Bioavailability and pharmacokinetics of (poly)phenols following consumption of selected blueberries and a blueberry-rich protein bar by adult males and females: a randomized, crossover, controlled trial
Bioavailability and pharmacokinetics of (poly)phenols following consumption of selected blueberries and a blueberry-rich protein bar by adult males and females: a randomized, crossover, controlled trial Open
Differing berry (poly)phenol content and bioaccessibility only minimally affect bioavailability following consumption of blueberries relative to a blueberry-rich protein bar, suggesting (poly)phenol-dense foods, such as bars and snacks, co…
View article: Gut microbes modulate the effects of the flavonoid quercetin on atherosclerosis
Gut microbes modulate the effects of the flavonoid quercetin on atherosclerosis Open
View article: Neuropsychological Impacts in Relapsing Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: A Case Series
Neuropsychological Impacts in Relapsing Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: A Case Series Open
View article: Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers
Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers Open
There is an increasing body of evidence indicating that phenolic compounds derived from microbiota-mediated breakdown of dietary (poly)phenolics in the colon are at least partially responsible for the beneficial effects of a plant-based di…
View article: Unraveling Protein-Metabolite Interactions in Precision Nutrition: A Case Study of Blueberry-Derived Metabolites Using Advanced Computational Methods
Unraveling Protein-Metabolite Interactions in Precision Nutrition: A Case Study of Blueberry-Derived Metabolites Using Advanced Computational Methods Open
Metabolomics, the study of small-molecule metabolites within biological systems, has become a potent instrument for understanding cellular processes. Despite its profound insights into health, disease, and drug development, identifying the…
View article: Quantitative Metabolomics-Driven Protein Target Prediction: A Computational Workflow for Precision Nutrition Discovery
Quantitative Metabolomics-Driven Protein Target Prediction: A Computational Workflow for Precision Nutrition Discovery Open
Objectives: Metabolomics explores complex relationships between small-molecule metabolites and biological systems, and has evolved into a potent tool for unraveling the intricacies of cellular processes. Even though it offers profound insi…
View article: Chronic and postprandial effect of blueberries on cognitive function, alertness, and mood in participants with metabolic syndrome – results from a six-month, double-blind, randomized controlled trial
Chronic and postprandial effect of blueberries on cognitive function, alertness, and mood in participants with metabolic syndrome – results from a six-month, double-blind, randomized controlled trial Open
Although self-rated calmness improved postprandially, and significant cognition-metabolite associations were identified, our data did not support strong cognitive, mood, alertness, or sleep quality improvements in MetS participants after b…
View article: Genotype and ripening method affect carotenoid content and bio-accessibility in banana
Genotype and ripening method affect carotenoid content and bio-accessibility in banana Open
This study concludes that the genotype, ripening methods (natural vs. exogenous ethylene application), and carotenoid bioaccessible content should be considered when setting a nutrition goal for vitamin A biofortification in banana-breedin…
View article: Contents list
Contents list Open
View article: PTFS11-05-23 Effect of Cultivar and Processing on the Bioavailability of (Poly)phenols Using Blueberries as a Model Fruit
PTFS11-05-23 Effect of Cultivar and Processing on the Bioavailability of (Poly)phenols Using Blueberries as a Model Fruit Open
View article: PTFS11-03-23 Consumption of Mango (Mangifera indica L.) Supplemented With Probiotics Modulates Gastrointestinal Hormones, Apolipoproteins, and Gut Health in Lean and Obese Individuals
PTFS11-03-23 Consumption of Mango (Mangifera indica L.) Supplemented With Probiotics Modulates Gastrointestinal Hormones, Apolipoproteins, and Gut Health in Lean and Obese Individuals Open
View article: OR13-07-23 Enhanced Anthocyanin Metabolite Excretion in Adults With the Genotype for Persistent Lactase Expression
OR13-07-23 Enhanced Anthocyanin Metabolite Excretion in Adults With the Genotype for Persistent Lactase Expression Open
View article: Performance of Urinary Phenyl-γ-Valerolactones as Biomarkers of Dietary Flavan-3-ol Exposure
Performance of Urinary Phenyl-γ-Valerolactones as Biomarkers of Dietary Flavan-3-ol Exposure Open
View article: Bioavailable Microbial Metabolites of Flavanols Demonstrate Highly Individualized Bioactivity on In Vitro β-Cell Functions Critical for Metabolic Health
Bioavailable Microbial Metabolites of Flavanols Demonstrate Highly Individualized Bioactivity on In Vitro β-Cell Functions Critical for Metabolic Health Open
Dietary flavanols are known for disease preventative properties but are often poorly absorbed. Gut microbiome flavanol metabolites are more bioavailable and may exert protective activities. Using metabolite mixtures extracted from the urin…
View article: A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study
A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study Open
These results suggest that cosupplementation with ω-3 PUFAs and cocoa flavanols for 12 mo does not improve cognitive outcomes in those with cognitive impairment. This trial was registered at clinicaltrials.gov as NCT02525198.
View article: Performance of urinary phenyl-γ-valerolactones as biomarkers of dietary flavan-3-ol exposure
Performance of urinary phenyl-γ-valerolactones as biomarkers of dietary flavan-3-ol exposure Open
Background Phenyl- γ- valerolactones (PVLs) have been proposed as potential biomarkers of dietary flavan-3-ol exposure. Objective We investigate the performance of a range of PVLs as biomarkers indicative of flavan-3-ol intake. Methods We …
View article: Gut microbiota and diet matrix modulate the effects of the flavonoid quercetin on atherosclerosis
Gut microbiota and diet matrix modulate the effects of the flavonoid quercetin on atherosclerosis Open
View article: Almond intake alters the acute plasma dihydroxy-octadecenoic acid (DiHOME) response to eccentric exercise
Almond intake alters the acute plasma dihydroxy-octadecenoic acid (DiHOME) response to eccentric exercise Open
Introduction This investigation determined if 4-weeks ingestion of nutrient-dense almonds mitigated post-exercise inflammation and muscle soreness and damage. Methods An acute 90-min of eccentric exercise (90-EE) was used to induce muscle …
View article: Mango (Mangifera indica L.) Polyphenols Enhanced by Supplemental Probiotics Improve Biomarkers for Inflammation and Cognitive Function in Lean and Obese Individuals
Mango (Mangifera indica L.) Polyphenols Enhanced by Supplemental Probiotics Improve Biomarkers for Inflammation and Cognitive Function in Lean and Obese Individuals Open
View article: The Metabolome of Food Knowledge Database: Development of a Nutrition Database to Support Precision Nutrition
The Metabolome of Food Knowledge Database: Development of a Nutrition Database to Support Precision Nutrition Open
OBJECTIVES: To develop a precision nutrition knowledge database, with the aim to provide individualized and actionable dietary recommendations to help prevent disease. However presently, dietary phytochemicals are poorly represented in cur…
View article: Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: a pilot study
Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: a pilot study Open
Type 2 diabetes (T2D) is characterized by hyperglycemia and insulin resistance. Cocoa may slow T2D development and progression. This study employed male and female BTBR.Cg- Lep ob/ob /WiscJ ( ob/ob ) and wild type (WT) controls to assess t…
View article: Effect of Wild Blueberry Metabolites on Biomarkers of Gastrointestinal and Immune Health In Vitro
Effect of Wild Blueberry Metabolites on Biomarkers of Gastrointestinal and Immune Health In Vitro Open
Wild blueberries (Vaccinium angustifolium Aiton.) are a rich source of dietary fiber and (poly)phenols with gastrointestinal and immune health-promoting properties, however, their mechanisms of action on the intestinal epithelial cells and…
View article: A randomized placebo-controlled cross-over study on the effects of anthocyanins on inflammatory and metabolic responses to a high-fat meal in healthy subjects
A randomized placebo-controlled cross-over study on the effects of anthocyanins on inflammatory and metabolic responses to a high-fat meal in healthy subjects Open
This study investigated the effects of supplementation with a cyanidin- and delphinidin-rich extract (CDRE) on the postprandial dysmetabolism, inflammation, and redox and insulin signaling, triggered by the consumption of a high fat meal (…
View article: Exploring the Contribution of (Poly)phenols to the Dietary Exposome Using High Resolution Mass Spectrometry Untargeted Metabolomics
Exploring the Contribution of (Poly)phenols to the Dietary Exposome Using High Resolution Mass Spectrometry Untargeted Metabolomics Open
Scope This study presents a workflow to construct a Dietary Exposome Library (DEL) comprised of phytochemicals and their metabolites derived from host and gut microbiome metabolism for use in peak identification/annotation of untargeted me…