Colin D. Paul
YOU?
Author Swipe
View article: Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indications
Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indications Open
View article: 428 Generation of a panel of patient-derived tumoroids for screening the potency of immunotherapies
428 Generation of a panel of patient-derived tumoroids for screening the potency of immunotherapies Open
View article: Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indications in a common base culture media system
Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indications in a common base culture media system Open
Tumoroids, also known as cancer organoids, are patient-derived cancer cells grown as 3D, self-organized multicellular structures that maintain key characteristics (e.g., genotype, gene expression levels) of the tumor from which they origin…
View article: YAP localization mediates mechanical adaptation of human cancer cells during extravasation<i>in vivo</i>
YAP localization mediates mechanical adaptation of human cancer cells during extravasation<i>in vivo</i> Open
Biophysical profiling of primary tumors has revealed that individual tumor cells fall along a highly heterogeneous continuum of mechanical phenotypes. One idea is that a subset of tumor cells is “softer” to facilitate detachment and escape…
View article: Extracellular fluid viscosity enhances cell migration and cancer dissemination
Extracellular fluid viscosity enhances cell migration and cancer dissemination Open
View article: Tissue Architectural Cues Drive Organ Targeting of Tumor Cells in Zebrafish
Tissue Architectural Cues Drive Organ Targeting of Tumor Cells in Zebrafish Open
View article: High-frequency microrheology in 3D reveals mismatch between cytoskeletal and extracellular matrix mechanics
High-frequency microrheology in 3D reveals mismatch between cytoskeletal and extracellular matrix mechanics Open
Significance Mechanical homeostasis describes how cells sense physical cues from the microenvironment and concomitantly remodel both the cytoskeleton and the surrounding extracellular matrix (ECM). However, the nature of the dynamic coupli…
View article: Human macrophages survive and adopt activated genotypes in living zebrafish
Human macrophages survive and adopt activated genotypes in living zebrafish Open
View article: Tissue architectural cues drive organ targeting of human tumor cells in zebrafish
Tissue architectural cues drive organ targeting of human tumor cells in zebrafish Open
Sites of metastasis are non-random, with certain types of cancers showing organ preference during distal colonization. Using multiple brain- and bone marrow-seeking human and murine breast cancer subclones, we determined that tumor cells t…
View article: Human macrophages survive and adopt activated genotypes in living zebrafish
Human macrophages survive and adopt activated genotypes in living zebrafish Open
The inflammatory response, modulated both by tissue resident macrophages and recruited monocytes from peripheral blood, plays a critical role in human diseases such as cancer and neurodegenerative disorders. Here, we sought a model to inte…
View article: Cancer cell motility: lessons from migration in confined spaces
Cancer cell motility: lessons from migration in confined spaces Open
View article: Engineered Models of Confined Cell Migration
Engineered Models of Confined Cell Migration Open
Cells in the body are physically confined by neighboring cells, tissues, and the extracellular matrix. Although physical confinement modulates intracellular signaling and the underlying mechanisms of cell migration, it is difficult to stud…
View article: Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit
Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit Open
Obscurins are a family of giant cytoskeletal proteins, originally identified in striated muscles where they have structural and regulatory roles. We recently showed that obscurins are abundantly expressed in normal breast epithelial cells …
View article: Interplay of the physical microenvironment, contact guidance, and intracellular signaling in cell decision making
Interplay of the physical microenvironment, contact guidance, and intracellular signaling in cell decision making Open
The peritumoral physical microenvironment consists of complex topographies that influence cell migration. Cell decision making, upon encountering anisotropic, physiologically relevant physical cues, has yet to be elucidated. By integrating…
View article: Time-lapse lens-free imaging of cell migration in diverse physical microenvironments
Time-lapse lens-free imaging of cell migration in diverse physical microenvironments Open
Lens-free imaging using coherent illumination is established as an inexpensive and reliable alternative to conventional phase contrast microscopy for live-cell imaging applications.