W. Colin Duncan
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View article: An ovine model shows that subcutaneous adipose tissue fibrosis occurs early in polycystic ovary syndrome (PCOS)
An ovine model shows that subcutaneous adipose tissue fibrosis occurs early in polycystic ovary syndrome (PCOS) Open
Prenatally androgenised (PA) sheep are a clinically realistic model of polycystic ovary syndrome (PCOS). They have dysfunctional subcutaneous adipose tissue (SAT) with reduced adipogenesis in adolescence and enlarged adipocytes with increa…
View article: Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women
Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women Open
Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However se…
View article: A core outcome set for future male infertility research: development of an international consensus
A core outcome set for future male infertility research: development of an international consensus Open
STUDY QUESTION Can a core outcome set be developed through a global consensus to standardize outcome selection, collection, comparison, and reporting in future male infertility trials? SUMMARY ANSWER A minimum dataset, known as a ‘core out…
View article: Mapping of prostate cancer microvascular patterns using super-resolution ultrasound imaging
Mapping of prostate cancer microvascular patterns using super-resolution ultrasound imaging Open
Background Super-resolution ultrasound imaging (SRUI) is a rapidly expanding field with the potential to impact cancer management. Image processing algorithms applied to contrast-enhanced ultrasound (CEUS) video data can track the path of …
View article: Insights into the effects of sex and tissue location on the evolution of adipocyte dysfunction in an ovine model of polycystic ovary syndrome (PCOS)
Insights into the effects of sex and tissue location on the evolution of adipocyte dysfunction in an ovine model of polycystic ovary syndrome (PCOS) Open
Adipose tissue dysfunction is one of the features of Polycystic Ovary Syndrome (PCOS) with dysregulated adipogenesis, altered functional pathways and increased inflammation. It is increasingly clear that there are also male correlates of t…
View article: Recent advances in the understanding of tubal ectopic pregnancy
Recent advances in the understanding of tubal ectopic pregnancy Open
Ectopic pregnancy (EP) is described as the implantation of an embryo outside the normal uterine cavity. It most commonly occurs in the fallopian tube, hence termed a tubal ectopic pregnancy (tEP). It is a gynaecological emergency and remai…
View article: Development of an acute ovine model of polycystic ovaries to assess the effect of ovarian denervation
Development of an acute ovine model of polycystic ovaries to assess the effect of ovarian denervation Open
Introduction Polycystic ovary syndrome (PCOS) seems to be associated with increased ovarian sympathetic nerve activity and in rodent models of PCOS reducing the sympathetic drive to the ovary, through denervation or neuromodulation, improv…
View article: P-524 Fertility and subsequent pregnancy outcomes among women with tubal ectopic pregnancy treated with methotrexate
P-524 Fertility and subsequent pregnancy outcomes among women with tubal ectopic pregnancy treated with methotrexate Open
Study question What are the future fertility prospects and subsequent pregnancy outcomes among women with tubal ectopic pregnancy treated with methotrexate? Summary answer Pregnancy post-ectopic pregnancy occurred in 53% of women within 12…
View article: Gefitinib and methotrexate to resolve tubal ectopic pregnancy: the GEM3 RCT
Gefitinib and methotrexate to resolve tubal ectopic pregnancy: the GEM3 RCT Open
Background Tubal ectopic pregnancies can cause significant morbidity or even death. Current treatment is with methotrexate or surgery. However, methotrexate treatment can fail in approximately 30% of women. Gefitinib, an epidermal growth f…
View article: P-467 Early (day 1–4) post-treatment serum hCG level changes predict single-dose methotrexate treatment success in tubal ectopic pregnancy
P-467 Early (day 1–4) post-treatment serum hCG level changes predict single-dose methotrexate treatment success in tubal ectopic pregnancy Open
Study question How effective is the change between day 1 and 4 post-treatment serum hCG level at predicting single-dose methotrexate treatment success in tubal ectopic pregnancy (tEP)? Summary answer Any fall in day 1–4 serum hCG signifies…
View article: Early (Days 1–4) post-treatment serum hCG level changes predict single-dose methotrexate treatment success in tubal ectopic pregnancy
Early (Days 1–4) post-treatment serum hCG level changes predict single-dose methotrexate treatment success in tubal ectopic pregnancy Open
STUDY QUESTION What is the capacity of the change between Day 1 and Day 4 post-treatment serum human chorionic gonadotropin (hCG) levels for predicting single-dose methotrexate treatment success in tubal ectopic pregnancy? SUMMARY ANSWER A…
View article: Subsequent pregnancy outcomes among women with tubal ectopic pregnancy treated with methotrexate
Subsequent pregnancy outcomes among women with tubal ectopic pregnancy treated with methotrexate Open
Graphical abstract Lay summary An ectopic pregnancy occurs when an embryo implants outside of the uterus, usually in a fallopian tube. When detected early, treatment is often with a medication called methotrexate. When methotrexate does no…
View article: Targeted deletion of <i>Fgf9</i> in tendon disrupts mineralization of the developing enthesis
Targeted deletion of <i>Fgf9</i> in tendon disrupts mineralization of the developing enthesis Open
The enthesis is a transitional tissue between tendon and bone that matures postnatally. The development and maturation of the enthesis involve cellular processes likened to an arrested growth plate. In this study, we explored the role of f…
View article: Combination of gefitinib and methotrexate to treat tubal ectopic pregnancy (GEM3): a multicentre, randomised, double-blind, placebo-controlled trial
Combination of gefitinib and methotrexate to treat tubal ectopic pregnancy (GEM3): a multicentre, randomised, double-blind, placebo-controlled trial Open
National Institute of Health Research.
View article: The impact of COVID-19 on the assessment and management of ectopic pregnancies
The impact of COVID-19 on the assessment and management of ectopic pregnancies Open
Lay Summary During the COVID-19 pandemic, the public delayed seeking medical help, which may have affected the impact of having an ectopic pregnancy. An ectopic pregnancy is when pregnancy tissue grows outside its normal position in the wo…
View article: Targeted Deletion of <i>Fgf9</i> in Tendon Disrupts Mineralization of the Developing Enthesis
Targeted Deletion of <i>Fgf9</i> in Tendon Disrupts Mineralization of the Developing Enthesis Open
The enthesis is a transitional tissue between tendon and bone that matures postnatally. The development and maturation of the enthesis involve cellular processes likened to an arrested growth plate. In this study, we explored the role of f…
View article: Evolutionary survival strategies of the female giant panda: optimizing energy resources and expenditure prior to pregnancy by postponing corpus luteum reactivation
Evolutionary survival strategies of the female giant panda: optimizing energy resources and expenditure prior to pregnancy by postponing corpus luteum reactivation Open
The giant panda reproductive physiology shows important similarities with at least six of the eight existing bear species: the occurrence of diapause and/or pseudopregnancy is commonly described in bears. Nevertheless, significant differen…
View article: The novel use of urinary androgens to optimise detection of the fertile window in giant pandas
The novel use of urinary androgens to optimise detection of the fertile window in giant pandas Open
Graphical abstract Abstract Giant pandas are mono-estrus seasonal breeders, with the breeding season typically occurring in the spring. Successful fertilization is followed by an embryonic diapause, of variable length, with birth in the la…
View article: Hepatic Mitochondrial Dysfunction and Risk of Liver Disease in an Ovine Model of “PCOS Males”
Hepatic Mitochondrial Dysfunction and Risk of Liver Disease in an Ovine Model of “PCOS Males” Open
First-degree male relatives of polycystic ovary syndrome (PCOS) sufferers can develop metabolic abnormalities evidenced by elevated circulating cholesterol and triglycerides, suggestive of a male PCOS equivalent. Similarly, male sheep over…
View article: Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses
Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses Open
Maternal exposure to increased steroid hormones, including estrogens, androgens or glucocorticoids during pregnancy results in chronic conditions in offspring that manifest in adulthood. Little is known about effects of progesterone admini…
View article: Association of Past <i>Chlamydia trachomatis</i> Infection With Miscarriage
Association of Past <i>Chlamydia trachomatis</i> Infection With Miscarriage Open
This case-control study assesses the association between past Chlamydia trachomatis infection with first-trimester miscarriage by using an enzyme-linked immunosorbent assay to detect antibodies to the protein Pgp3.
View article: Targeting colony stimulating factor-1 receptor signalling to treat ectopic pregnancy
Targeting colony stimulating factor-1 receptor signalling to treat ectopic pregnancy Open
1–2% of pregnancies are ectopic, the majority implanting in the Fallopian tube. A single, systemic dose of methotrexate, a DNA-synthesis (S phase) inhibitor, has been used since 1991 for outpatient treatment of women with stable EP. Howeve…
View article: Progesterone to prevent miscarriage in women with early pregnancy bleeding: the PRISM RCT
Progesterone to prevent miscarriage in women with early pregnancy bleeding: the PRISM RCT Open
Background Progesterone is essential for a healthy pregnancy. Several small trials have suggested that progesterone therapy may rescue a pregnancy in women with early pregnancy bleeding, which is a symptom that is strongly associated with …
View article: Insights into Manipulating Postprandial Energy Expenditure to Manage Weight Gain in Polycystic Ovary Syndrome
Insights into Manipulating Postprandial Energy Expenditure to Manage Weight Gain in Polycystic Ovary Syndrome Open
Women with polycystic ovary syndrome (PCOS) are more likely to be obese and have difficulty in losing weight. They demonstrate an obesity-independent deficit in adaptive energy expenditure. We used a clinically realistic preclinical model …
View article: Fetal androgen exposure is a determinant of adult male metabolic health
Fetal androgen exposure is a determinant of adult male metabolic health Open
Androgen signalling is a critical driver of male development. Fetal steroid signalling can be dysregulated by a range of environmental insults and clinical conditions. We hypothesised that poor adult male health was partially attributable …