Colin Green
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View article: ENHANCING PRODUCTIVITY AND SUSTAINABILITY IN MANUFACTURING THROUGH DYNAMIC CONTROL OF 5-AXIS CONICAL TAPER BARREL MACHINING OPERATIONS
ENHANCING PRODUCTIVITY AND SUSTAINABILITY IN MANUFACTURING THROUGH DYNAMIC CONTROL OF 5-AXIS CONICAL TAPER BARREL MACHINING OPERATIONS Open
The machining industry aims to boost productivity and sustainability through advanced machining strategies like conical taper barrel milling. These tools, with large contact radii, enhance surface quality, efficiency, and material removal …
View article: Beyond named methods: A typology of active learning based on classroom observation networks
Beyond named methods: A typology of active learning based on classroom observation networks Open
A growing number of introductory physics instructors are implementing active learning methods in their classrooms, and they are modifying the methods to fit their local instructional contexts. However, we lack a detailed framework for desc…
View article: Improving our understanding of physicists through natural language processing
Improving our understanding of physicists through natural language processing Open
Physics education research (PER) has long struggled with how to manage the desire to use qualitative, or text based, data with the proportionately higher cost of analyzing and collecting this type of data. We present several methods and us…
View article: Relative benefits of different active learning methods to conceptual physics learning
Relative benefits of different active learning methods to conceptual physics learning Open
Extensive research has demonstrated that active learning methods are more effective than traditional lecturing at improving student conceptual understanding and reducing failure rates in undergraduate physics courses. Researchers have deve…
View article: Requirement for Fc effector function is overcome by binding potency for broadly reactive anti-alphavirus antibodies
Requirement for Fc effector function is overcome by binding potency for broadly reactive anti-alphavirus antibodies Open
Alphaviruses are emerging public health threats. Broadly reactive anti-alphavirus monoclonal antibodies (mAbs) have been shown to be protective in mouse models of infection. However, the mechanism of Fc-dependent or Fc-independent heterolo…
View article: Literature review and meta-analysis of natalizumab therapy for the treatment of highly active relapsing remitting multiple sclerosis in the ‘suboptimal therapy’ patient population
Literature review and meta-analysis of natalizumab therapy for the treatment of highly active relapsing remitting multiple sclerosis in the ‘suboptimal therapy’ patient population Open
Literature reviewed indicates that natalizumab is more effective than other included treatments for SOT patients. Findings were consistent with studies in the broad HA RRMS population, suggesting that natalizumab may have similar efficacy …
View article: To the 70th Anniversary of Ukraine’s Membership in UNESCO. UNESCO Chair in Cryobiology: Milestones, Experience, Results, Perspectives
To the 70th Anniversary of Ukraine’s Membership in UNESCO. UNESCO Chair in Cryobiology: Milestones, Experience, Results, Perspectives Open
View article: Correlative light and X-ray tomography jointly unveil the critical role of connexin43 channels on inflammation-induced cellular ultrastructural alterations
Correlative light and X-ray tomography jointly unveil the critical role of connexin43 channels on inflammation-induced cellular ultrastructural alterations Open
Non-junctional connexin43 (Cx43) plasma membrane hemichannels have been implicated in several inflammatory diseases, particularly playing a role in ATP release that triggers activation of the inflammasome. Therapies targeting the blocking …
View article: Tonabersat Significantly Reduces Disease Progression in an Experimental Mouse Model of Multiple Sclerosis
Tonabersat Significantly Reduces Disease Progression in an Experimental Mouse Model of Multiple Sclerosis Open
Multiple sclerosis (MS) is a neurodegenerative disease marked by chronic neuroinflammation thought to be mediated by the inflammasome pathway. Connexin 43 (Cx43) hemichannels contribute to the activation of the inflammasome through the rel…
View article: Effectiveness and cost‐effectiveness of behavioural support for prolonged abstinence for smokers wishing to reduce but not quit: Randomised controlled trial of physical activity assisted reduction of smoking (TARS)
Effectiveness and cost‐effectiveness of behavioural support for prolonged abstinence for smokers wishing to reduce but not quit: Randomised controlled trial of physical activity assisted reduction of smoking (TARS) Open
Aims For smokers unmotivated to quit, we assessed the effectiveness and cost‐effectiveness of behavioural support to reduce smoking and increase physical activity on prolonged abstinence and related outcomes. Design A multi‐centred pragmat…
View article: Randomised controlled trial of tailored support to increase physical activity and reduce smoking in smokers not immediately ready to quit: protocol for the Trial of physical Activity-assisted Reduction of Smoking (TARS) Study
Randomised controlled trial of tailored support to increase physical activity and reduce smoking in smokers not immediately ready to quit: protocol for the Trial of physical Activity-assisted Reduction of Smoking (TARS) Study Open
Introduction Smoking reduction can lead to increased success in quitting. This study aims to determine if a client-focused motivational support package for smoking reduction (and quitting) and increasing (or otherwise using) physical activ…
View article: Connexin therapeutics: blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions
Connexin therapeutics: blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions Open
Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of diseases. Some of these compounds are now in clinical trials, but for many of them, the literature i…
View article: Current understanding of Age-related macular degeneration
Current understanding of Age-related macular degeneration Open
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population 50 years of age or older in the developed countries. This review discusses the traditional clinical and histopathological prese…
View article: Connexin43 Expression and Associated Chronic Inflammation Presages the Development of Cerebral Radiation Necrosis
Connexin43 Expression and Associated Chronic Inflammation Presages the Development of Cerebral Radiation Necrosis Open
Cerebral radiation necrosis (CRN) is a delayed complication of radiosurgery that can result in severe neurological deficits. The biological changes leading to necrotic damage may identify therapeutic targets for this complication. Connexin…
View article: Health state utility values (QALY weights) for Huntington’s disease: an analysis of data from the European Huntington’s Disease Network (EHDN)
Health state utility values (QALY weights) for Huntington’s disease: an analysis of data from the European Huntington’s Disease Network (EHDN) Open
View article: Connexin hemichannel block shuts down inflammation in an animal model of chronic diabetic retinopathy to improve structural and functional outcomes
Connexin hemichannel block shuts down inflammation in an animal model of chronic diabetic retinopathy to improve structural and functional outcomes Open
View article: Corneal Curvature: the Influence of Corneal Accommodation and Biomechanics on Corneal Shape
Corneal Curvature: the Influence of Corneal Accommodation and Biomechanics on Corneal Shape Open
An externally mounted beam splitter can be used to modify the visual target presented by clinical ocular imaging instruments. Corneal conformational changes during accommodation may be useful in the diagnosis of corneal ectasia.
View article: Managing Bridge Scour Risk Using Structural Health Monitoring
Managing Bridge Scour Risk Using Structural Health Monitoring Open
Scour is the leading cause of bridge failures worldwide.In the United States, 22 bridges fail every year, whereas in the UK scour contributed significantly to the 138 bridge collapses recorded in the last century.In Scotland, there are aro…
View article: Additional file 4: of Using the Fatigue Severity Scale to inform healthcare decision-making in multiple sclerosis: mapping to three quality-adjusted life-year measures (EQ-5D-3L, SF-6D, MSIS-8D)
Additional file 4: of Using the Fatigue Severity Scale to inform healthcare decision-making in multiple sclerosis: mapping to three quality-adjusted life-year measures (EQ-5D-3L, SF-6D, MSIS-8D) Open
All model results. (XLSX 52 kb)
View article: The effects and costs of home-based rehabilitation for heart failure with reduced ejection fraction: The REACH-HF multicentre randomized controlled trial
The effects and costs of home-based rehabilitation for heart failure with reduced ejection fraction: The REACH-HF multicentre randomized controlled trial Open
Background Cardiac rehabilitation improves health-related quality of life (HRQoL) and reduces hospitalizations in patients with heart failure, but international uptake of cardiac rehabilitation for heart failure remains low. Design and met…
View article: Prueba clínica controlada de estimulación subcutánea para dolor lumbar por cirugía fallida de columna: el estudio SubQStim.
Prueba clínica controlada de estimulación subcutánea para dolor lumbar por cirugía fallida de columna: el estudio SubQStim. Open
Objetivos: Comparar la eficacia de la estimulación neural periférica utilizando la técnica de implante subcutánea Estimulación nerviosa subcutánea (codificada SQS) más el manejo médico óptimo (codificado SQS + OMM arm) vs manejo médico ópt…
View article: Intravitreal pro-inflammatory cytokines in non-obese diabetic mice: Modelling signs of diabetic retinopathy
Intravitreal pro-inflammatory cytokines in non-obese diabetic mice: Modelling signs of diabetic retinopathy Open
Diabetic retinopathy is a vascular disease of the retina characterised by hyperglycaemic and inflammatory processes. Most animal models of diabetic retinopathy are hyperglycaemia-only models that do not account for the significant role tha…
View article: Involvement of Connexin Hemichannels in the Inflammatory Response of Chronic Diseases
Involvement of Connexin Hemichannels in the Inflammatory Response of Chronic Diseases Open
Over the last decade it has become evident that under normal conditions connexin hemichannels are either not expressed (e.g., skeletal muscle) or are expressed in very low numbers with low open probability in various mammalian tissues (e.g…
View article: Sustained Connexin43 Mimetic Peptide Release From Loaded Nanoparticles Reduces Retinal and Choroidal Photodamage
Sustained Connexin43 Mimetic Peptide Release From Loaded Nanoparticles Reduces Retinal and Choroidal Photodamage Open
The slow release of Cx43MP incorporated into NPs is more effective at treating retinal injury than a single dose of native Cx43MP in solution by reducing inflammation and maintaining both retinal structure and function. This NP preparation…
View article: The therapeutic potential of XG19 in a mouse model of choroidal neovascularization
The therapeutic potential of XG19 in a mouse model of choroidal neovascularization Open
View article: Intravitreal pro-inflammatory cytokines induce signs of diabetic retinopathy in non-obese diabetic mice
Intravitreal pro-inflammatory cytokines induce signs of diabetic retinopathy in non-obese diabetic mice Open
View article: A Randomized Controlled Trial of Subcutaneous Nerve Stimulation for Back Pain Due to Failed Back Surgery Syndrome: The SubQStim Study
A Randomized Controlled Trial of Subcutaneous Nerve Stimulation for Back Pain Due to Failed Back Surgery Syndrome: The SubQStim Study Open
View article: A randomised controlled trial of a facilitated home-based rehabilitation intervention in patients with heart failure with preserved ejection fraction and their caregivers: the REACH-HFpEF Pilot Study
A randomised controlled trial of a facilitated home-based rehabilitation intervention in patients with heart failure with preserved ejection fraction and their caregivers: the REACH-HFpEF Pilot Study Open
Introduction Home-based cardiac rehabilitation may overcome suboptimal rates of participation. The overarching aim of this study was to assess the feasibility and acceptability of the novel Rehabilitation EnAblement in CHronic Hear Failure…
View article: Issue Information
Issue Information Open
Aims and Scope: For more than 50 years, clinical pharmacologists, clinical and pharmaceutical researchers, drug development specialists, physicians, nurses, and other medical professionals have relied on The Journal of Clinical Pharmacolog…
View article: Glia and hemichannels: key mediators of perinatal encephalopathy
Glia and hemichannels: key mediators of perinatal encephalopathy Open
Perinatal encephalopathy remains a major cause of disability, such as cerebral palsy. Therapeutic hypothermia is now well established to partially reduce risk of disability in late preterm/term infants. However, new and complementary thera…