Colin Hawco
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View article: Temporal dynamics in neuroimaging as correlates of therapeutic response to psilocybin in major depressive disorder: A systematic review and critical appraisal
Temporal dynamics in neuroimaging as correlates of therapeutic response to psilocybin in major depressive disorder: A systematic review and critical appraisal Open
Although these findings suggest psilocybin is associated with dynamic and temporally distinct neuroplastic changes linked to clinical improvement, several limitations must be acknowledged. Many studies reused overlapping datasets with high…
View article: Transdiagnostic Profiles of BOLD Signal Variability in Autism and Schizophrenia Spectrum Disorders: Associations with Cognition and Functioning
Transdiagnostic Profiles of BOLD Signal Variability in Autism and Schizophrenia Spectrum Disorders: Associations with Cognition and Functioning Open
Background Autism spectrum disorder (autism) and schizophrenia spectrum disorders (schizophrenia) exhibit overlapping social and neurocognitive impairment and considerable neurobiological heterogeneity. Blood-oxygen-level-dependent (BOLD) …
View article: A longitudinal study of changes in depressive symptoms and risk factors for congestive heart failure
A longitudinal study of changes in depressive symptoms and risk factors for congestive heart failure Open
Background Depression is prevalent among patients with congestive heart failure (CHF) and is associated with increased mortality and healthcare use. However, most research on this association has focused on high-income countries, leaving a…
View article: Comparative Analysis of Social Cognitive and Neurocognitive Performance Across Autism and Schizophrenia Spectrum Disorders
Comparative Analysis of Social Cognitive and Neurocognitive Performance Across Autism and Schizophrenia Spectrum Disorders Open
Background and Hypothesis Social cognitive and neurocognitive performance is impacted in autism and schizophrenia spectrum disorders (SSDs). Here, we compared social cognitive and neurocognitive performance across a large transdiagnostic s…
View article: Bayesian Optimization Of NeuroStimulation (BOONStim)
Bayesian Optimization Of NeuroStimulation (BOONStim) Open
View article: metasnf: Meta Clustering with Similarity Network Fusion
metasnf: Meta Clustering with Similarity Network Fusion Open
View article: metasnf: Meta Clustering with Similarity Network Fusion in R
metasnf: Meta Clustering with Similarity Network Fusion in R Open
metasnf is an R package that enables users to apply meta clustering, a method for efficiently searching a broad space of cluster solutions by clustering the solutions themselves, to clustering workflows based on similarity network fusion (…
View article: A longitudinal study of depressive symptom trajectories and risk factors in congestive heart failure
A longitudinal study of depressive symptom trajectories and risk factors in congestive heart failure Open
Background Depression is prevalent among patients with congestive heart failure (CHF) and is associated with increased mortality and healthcare utilization. However, most research has focused on high-income countries, leaving a gap in know…
View article: Task-based functional neural correlates of social cognition across autism and schizophrenia spectrum disorders
Task-based functional neural correlates of social cognition across autism and schizophrenia spectrum disorders Open
Background Autism and schizophrenia spectrum disorders (SSDs) both feature atypical social cognition. Despite evidence for comparable group-level performance in lower-level emotion processing and higher-level mentalizing, limited research …
View article: A systematic review of structural and functional magnetic resonance imaging studies on the neurobiology of depressive symptoms in schizophrenia spectrum disorders
A systematic review of structural and functional magnetic resonance imaging studies on the neurobiology of depressive symptoms in schizophrenia spectrum disorders Open
Depressive symptoms in Schizophrenia Spectrum Disorders (SSDs) negatively impact suicidality, prognosis, and quality of life. Despite this, efficacious treatments are limited, largely because the neural mechanisms underlying depressive sym…
View article: Transdiagnostic Neurobiology of Social Cognition and Individual Variability as Measured by Fractional Amplitude of Low-Frequency Fluctuation in Schizophrenia and Autism Spectrum Disorders
Transdiagnostic Neurobiology of Social Cognition and Individual Variability as Measured by Fractional Amplitude of Low-Frequency Fluctuation in Schizophrenia and Autism Spectrum Disorders Open
Fractional amplitude of low-frequency fluctuation (fALFF) is a validated measure of resting-state spontaneous brain activity. Previous fALFF findings in autism and schizophrenia spectrum disorders (ASDs and SSDs) have been highly heterogen…
View article: Functional phenotypes in schizophrenia spectrum disorders: defining the constructs and identifying biopsychosocial correlates using data-driven methods
Functional phenotypes in schizophrenia spectrum disorders: defining the constructs and identifying biopsychosocial correlates using data-driven methods Open
View article: Effects of repetitive transcranial magnetic stimulation on individual variability of resting-state functional connectivity in major depressive disorder
Effects of repetitive transcranial magnetic stimulation on individual variability of resting-state functional connectivity in major depressive disorder Open
Background: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder (MDD), but substantial heterogeneity in outcomes remains. We examined a potential mechanism of action of rTMS to normal…
View article: Altered Neural Activation in First Episode Psychosis Patients With Comorbid Conduct Disorder: A Pilot Investigation
Altered Neural Activation in First Episode Psychosis Patients With Comorbid Conduct Disorder: A Pilot Investigation Open
View article: Bayesian Optimization of Neurostimulation (BOONStim)
Bayesian Optimization of Neurostimulation (BOONStim) Open
Background Transcranial magnetic stimulation (TMS) treatment response is influenced by individual variability in brain structure and function. Sophisticated, user-friendly approaches, incorporating both established functional magnetic reso…
View article: Heterogeneity in functional connectivity: Dimensional predictors of individual variability during rest and task fMRI in psychosis
Heterogeneity in functional connectivity: Dimensional predictors of individual variability during rest and task fMRI in psychosis Open
View article: Genetic architecture of the structural connectome
Genetic architecture of the structural connectome Open
Myelinated axons form long-range connections that enable rapid communication between distant brain regions, but how genetics governs the strength and organization of these connections remains unclear. We perform genome-wide association stu…
View article: Functional magnetic resonance imaging in schizophrenia: current evidence, methodological advances, limitations and future directions
Functional magnetic resonance imaging in schizophrenia: current evidence, methodological advances, limitations and future directions Open
Functional neuroimaging emerged with great promise and has provided fundamental insights into the neurobiology of schizophrenia. However, it has faced challenges and criticisms, most notably a lack of clinical translation. This paper provi…
View article: Higher general intelligence is associated with stable, efficient, and typical dynamic functional brain connectivity patterns
Higher general intelligence is associated with stable, efficient, and typical dynamic functional brain connectivity patterns Open
General intelligence, referred to as g, is hypothesized to emerge from the capacity to dynamically and adaptively reorganize macroscale brain connectivity. Temporal reconfiguration can be assessed using dynamic functional connectivity (dFC…
View article: Comparing the stability and reproducibility of brain-behavior relationships found using canonical correlation analysis and partial least squares within the ABCD sample
Comparing the stability and reproducibility of brain-behavior relationships found using canonical correlation analysis and partial least squares within the ABCD sample Open
Canonical correlation analysis (CCA) and partial least squares correlation (PLS) detect linear associations between two data matrices by computing latent variables (LVs) having maximal correlation (CCA) or covariance (PLS). This study comp…
View article: Spatial-extent inference for testing variance components in reliability and heritability studies
Spatial-extent inference for testing variance components in reliability and heritability studies Open
Clusterwise inference is a popular approach in neuroimaging to increase sensitivity, but most existing methods are currently restricted to the General Linear Model (GLM) for testing mean parameters. Statistical methods for testing variance…
View article: Protocol for a systematic review and meta-analysis of coordinate-based network mapping of brain structure in bipolar disorder across the lifespan
Protocol for a systematic review and meta-analysis of coordinate-based network mapping of brain structure in bipolar disorder across the lifespan Open
Background Studies about brain structure in bipolar disorder have reported conflicting findings. These findings may be explained by the high degree of heterogeneity within bipolar disorder, especially if structural differences are mapped t…
View article: Heterogeneity in Functional Connectivity: Dimensional Predictors of Individual Variability during Rest and Task fMRI in Psychosis
Heterogeneity in Functional Connectivity: Dimensional Predictors of Individual Variability during Rest and Task fMRI in Psychosis Open
Background Individuals with schizophrenia spectrum disorders (SSD) often demonstrate cognitive impairments, associated with poor functional outcomes. While neurobiological heterogeneity has posed challenges when examining social cognition …
View article: Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): Study protocol
Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): Study protocol Open
Schizophrenia spectrum disorders (SSDs) are associated with significant functional impairments, disability, and low rates of personal recovery, along with tremendous economic costs linked primarily to lost productivity and premature mortal…
View article: A Neurocognitive Pathway to Social Cognitive Deficits in Schizophrenia: Inferring the Temporal Progression of Hippocampal Volume and Verbal Memory
A Neurocognitive Pathway to Social Cognitive Deficits in Schizophrenia: Inferring the Temporal Progression of Hippocampal Volume and Verbal Memory Open
Social cognitive deficits are key predictors of negative symptoms and poor functional outcome in schizophrenia. We propose a neurocognitive disease progression model of social cognitive deficits in psychosis, developing from hippocampal vo…
View article: A Neurocognitive Pathway to Social Cognitive Deficits in Schizophrenia: Inferring the Temporal Progression of Hippocampal Volume and Verbal Memory
A Neurocognitive Pathway to Social Cognitive Deficits in Schizophrenia: Inferring the Temporal Progression of Hippocampal Volume and Verbal Memory Open
Social cognitive deficits are key predictors of negative symptoms and poor functional outcome in schizophrenia. We propose a neurocognitive disease progression model of social cognitive deficits in psychosis, developing from hippocampal vo…
View article: Robust hierarchically organized whole‐brain patterns of dysconnectivity in schizophrenia spectrum disorders observed after personalized intrinsic network topography
Robust hierarchically organized whole‐brain patterns of dysconnectivity in schizophrenia spectrum disorders observed after personalized intrinsic network topography Open
Background Spatial patterns of brain functional connectivity can vary substantially at the individual level. Applying cortical surface‐based approaches with individualized rather than group templates may accelerate the discovery of biologi…
View article: Higher general intelligence is linked to stable, efficient, and typical dynamic functional brain connectivity patterns
Higher general intelligence is linked to stable, efficient, and typical dynamic functional brain connectivity patterns Open
General intelligence, referred to as g, is hypothesized to emerge from the capacity to dynamically and adaptively reorganize macroscale brain connectivity. Temporal reconfiguration can be assessed using dynamic functional connectivity (dFC…
View article: Subgenual cingulate connectivity as a treatment predictor during low-frequency right dorsolateral prefrontal rTMS: A concurrent TMS-fMRI study
Subgenual cingulate connectivity as a treatment predictor during low-frequency right dorsolateral prefrontal rTMS: A concurrent TMS-fMRI study Open
This was the first study to examine left sgACC anti-correlation with the right DLPFC during an LFR rTMS protocol. In contrast to studies that targeted the left DLPFC, we did not find that higher anti-correlation was associated with clinica…
View article: Isolating sensory artifacts in the suprathreshold TMS-EEG signal over DLPFC
Isolating sensory artifacts in the suprathreshold TMS-EEG signal over DLPFC Open
Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is an effective way to evaluate neurophysiological processes at the level of the cortex. To further characterize the TMS-evoked potential (TEP) generated with …