Colin Hockings YOU? Author Swipe

Last 10y

ARAP2 regulates responses to interferon-gamma by restricting SOCS1 Open

Narelle Keating, Karen Doggett, Grace M. Bidgood, Lizeth G. Meza Guzman, Laura F. Dagley , et al. · 2025

SUMMARY Interferon-gamma (IFNγ) is critical for immunity against intra-macrophagic pathogens, signaling through the JAK-STAT pathway to induce a tyrosine-phosphorylation cascade that ensures a potent immune response. Excessive JAK-STAT sig…

Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport Open

Tasuku Konno, Pierre Parutto, Cécile C. Crapart, Valentina Davì, David M. Bailey , et al. · 2024

Cell functions rely on intracellular transport systems distributing bioactive molecules with high spatiotemporal accuracy. The endoplasmic reticulum (ER) tubular network constitutes a system for delivering luminal solutes, including Ca

Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands Open

Edmond M. Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda , et al. · 2023

Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells Open

Clara Lopes Novo, Emily V. Wong, Colin Hockings, Chetan Poudel, Eleanor Sheekey , et al. · 2022

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands Open

Edmond M. Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda , et al. · 2021

Endoplasmic Reticulum morphological regulation by RTN4/NOGO modulates neuronal regeneration by curbing luminal transport Open

Tasuku Konno, Pierre Parutto, David M. Bailey, Valentina Davì, Cécile C. Crapart , et al. · 2021

Cell and tissue functions rely on an elaborate intracellular transport system responsible for distributing bioactive molecules with high spatiotemporal accuracy. The tubular network of the Endoplasmic Reticulum (ER) constitutes a system fo…

Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells Open

Clara Lopes Novo, Emily V. Wong, Colin Hockings, Chetan Poudel, Eleanor Sheekey , et al. · 2020

Summary Heterochromatin maintains genome integrity and function, and is organised into distinct nuclear domains. Some of these domains are proposed to form by phase separation through the accumulation of HP1α. Mammalian heterochromatin con…

Illuminating chromatin compaction in live cells and fixed tissues using SiR-DNA fluorescence lifetime Open

Colin Hockings, Chetan Poudel, Kevin A. Feeney, Clara Lopes Novo, Mehdi S. Hamouda , et al. · 2020

The global compaction state of chromatin in a nucleus is an important component of cell identity that has been difficult to measure. We have developed a quantitative method to measure the chromatin compaction state in both live and fixed c…

A waveguide imaging platform for live-cell TIRF imaging of neurons over large fields of view Open

Ida S. Opstad, Florian Ströhl, Marcus Fantham, Colin Hockings, Oliver Vanderpoorten , et al. · 2019

Large fields of view (FOVs) in total internal reflection fluorescence microscopy (TIRFM) via waveguides have been shown to be highly beneficial for single molecule localisation microscopy on fixed cells [1, 2] and have also been demonstrat…

A Highly Porous Metal-Organic Framework System to Deliver Payloads for Gene Knockdown Open

Michelle H. Teplensky, Marcus Fantham, Chetan Poudel, Colin Hockings, Meng Lü , et al. · 2019

Intra-mitochondrial proteostasis is directly coupled to alpha-synuclein and Amyloid β 1-42 pathology Open

Janin Lautenschläger, Sara Wagner-Valladolid, Amberley D. Stephens, Ana Fernández‐Villegas, Colin Hockings , et al. · 2019

Mitochondria have long been implicated in Parkinson’s disease (PD), however, it is not clear how mitochondrial impairment and alpha-synuclein pathology are coupled. We report here that intra-mitochondrial protein homeostasis plays a major …

VDAC2 enables BAX to mediate apoptosis and limit tumor development Open

Hui San Chin, Xiang Li, Iris K. L. Tan, Robert L. Ninnis, Boris Reljić , et al. · 2018

Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins Open

Colin Hockings, Amber E. Alsop, Stephanie C. Fennell, Erinna F. Lee, W. Douglas Fairlie , et al. · 2018

BAX requires VDAC2 to mediate apoptosis and to limit tumor development Open

Hui San Chin, Mark F. van Delft, Robert L. Ninnis, Xiang Li, Iris K. L. Tan , et al. · 2018

Intrinsic apoptosis is critical for normal physiology including the prevention of tumor formation. BAX and BAK are essential for mediating this process and for the cytotoxic action of many anticancer drugs. BAX and BAK are thought to act i…

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax Open

Colin Hockings, Khatira Anwari, Robert L. Ninnis, Jason M. Brouwer, Martin O’Hely , et al. · 2015

The mitochondrial pathway of apoptosis is initiated by Bcl-2 homology region 3 (BH3)-only members of the Bcl-2 protein family. On upregulation or activation, certain BH3-only proteins can directly bind and activate Bak and Bax to induce co…