Explanipedia

Temporal and Spatial Scales of Human Resting-state Cortical Activity Across the Lifespan Open

J. J. Bero, Colin Humphries, Yang Li, Aviral Kumar, Heungyeol Lee , et al. · 2025

Sensorimotor and cognitive abilities undergo substantial changes throughout the human lifespan, but the corresponding changes in the functional properties of cortical networks remain poorly understood. This can be studied using temporal an…

Predicting memory decline from left temporal lobe epilepsy surgery using preoperative fMRI: a multicenter study Open

William L. Gross, Sara J. Swanson, Alexander I. Helfand, Sara B. Pillay, Colin Humphries , et al. · 2025

T1−/T2‐weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy Open

Colin Denis, Kevin Dabbs, Veena A. Nair, Jedidiah Mathis, Dace Almane , et al. · 2023

Short‐range functional connectivity in the limbic network is increased in patients with temporal lobe epilepsy (TLE), and recent studies have shown that cortical myelin content correlates with fMRI connectivity. We thus hypothesized that m…

Coordinated anatomical and functional variability in the human brain during adolescence Open

J. J. Bero, Yang Li, Aviral Kumar, Colin Humphries, Snehesh Nag , et al. · 2022

Adolescence represents a time of unparalleled brain development. In particular, developmental changes in morphometric and cytoarchitectural features are accompanied by maturation in the functional connectivity (FC). Here, we examined how t…

Late dominance of the right hemisphere during narrative comprehension Open

Vahab Youssofzadeh, Lisa L. Conant, Jeffrey Stout, Candida Ustine, Colin Humphries , et al. · 2022

PET and fMRI studies suggest that auditory narrative comprehension is supported by a bilateral multilobar cortical network. The superior temporal resolution of magnetoencephalography (MEG) makes it an attractive tool to investigate the dyn…

A Distributed Network for Multimodal Experiential Representation of Concepts Open

Jia‐Qing Tong, Jeffrey R. Binder, Colin Humphries, Stephen Mazurchuk, Lisa L. Conant , et al. · 2022

Neuroimaging, neuropsychological, and psychophysical evidence indicate that concept retrieval selectively engages specific sensory and motor brain systems involved in the acquisition of the retrieved concept. However, it remains unclear wh…

Prediction of Naming Outcome With fMRI Language Lateralization in Left Temporal Epilepsy Surgery Open

William L. Gross, Alexander I. Helfand, Sara J. Swanson, Lisa L. Conant, Colin Humphries , et al. · 2022

This study provides Class I evidence that fMRI language lateralization can help in predicting naming decline after left TLE surgery.

Decoding the information structure underlying the neural representation of concepts Open

Leonardo Fernandino, Jia‐Qing Tong, Lisa L. Conant, Colin Humphries, Jeffrey R. Binder · 2022

Significance The ability to identify individual objects or events as members of a kind (e.g., “knife,” “dog,” or “party”) is a fundamental aspect of human cognition. It allows us to quickly access a wealth of information pertaining to a ne…

A Distributed Network for Multimodal Experiential Representation of Concepts Open

Jia‐Qing Tong, Jeffrey R. Binder, Colin Humphries, Stephen Mazurchuk, Lisa L. Conant , et al. · 2021

Neuroimaging, neuropsychological, and psychophysical evidence indicates that concept retrieval selectively engages specific sensory and motor brain systems involved in the acquisition of the retrieved concept. However, it remains unclear w…

Deep Artificial Neural Networks Reveal a Distributed Cortical Network Encoding Propositional Sentence-Level Meaning Open

Andrew J. Anderson, Douwe Kiela, Jeffrey R. Binder, Leonardo Fernandino, Colin Humphries , et al. · 2021

Understanding how and where in the brain sentence-level meaning is constructed from words presents a major scientific challenge. Recent advances have begun to explain brain activation elicited by sentences using vector models of word meani…

Decoding the Information Structure Underlying the Neural Representation of Concepts Open

Leonardo Fernandino, Jia‐Qing Tong, Lisa L. Conant, Colin Humphries, Jeffrey R. Binder · 2021

The nature of the representational code underlying conceptual knowledge remains a major unsolved problem in cognitive neuroscience. We assessed the extent to which different representational systems contribute to the instantiation of lexic…

Temporal lobe regions essential for preserved picture naming after left temporal epilepsy surgery Open

Jeffrey R. Binder, Jia‐Qing Tong, Sara B. Pillay, Lisa L. Conant, Colin Humphries , et al. · 2020

Objective To define left temporal lobe regions where surgical resection produces a persistent postoperative decline in naming visual objects. Methods Pre‐ and postoperative brain magnetic resonance imaging data and picture naming (Boston N…

Mapping language from MEG beta power modulations during auditory and visual naming Open

Vahab Youssofzadeh, Jeffrey Stout, Candida Ustine, William L. Gross, Lisa L. Conant , et al. · 2020

Changes in description naming for common and proper nouns after left anterior temporal lobectomy Open

Sara J. Swanson, Lisa L. Conant, Colin Humphries, Megan LeDoux, Manoj Raghavan , et al. · 2020

Brain aging in temporal lobe epilepsy: Chronological, structural, and functional Open

Gyujoon Hwang, Bruce P. Hermann, Veena A. Nair, Lisa L. Conant, Kevin Dabbs , et al. · 2020

An Integrated Neural Decoder of Linguistic and Experiential Meaning Open

Andrew Anderson, Jeffrey R. Binder, Leonardo Fernandino, Colin Humphries, Lisa L. Conant , et al. · 2019

The brain is thought to combine linguistic knowledge of words and nonlinguistic knowledge of their referents to encode sentence meaning. However, functional neuroimaging studies aiming at decoding language meaning from neural activity have…

Neuroanatomical correlates of personality traits in temporal lobe epilepsy: Findings from the Epilepsy Connectome Project Open

Charlene N. Rivera Bonet, Bruce P. Hermann, Cole J. Cook, Gyujoon Hwang, Kevin Dabbs , et al. · 2019

Cognitive slowing and its underlying neurobiology in temporal lobe epilepsy Open

Gyujoon Hwang, Kevin Dabbs, Lisa L. Conant, Veena A. Nair, Jed Mathis , et al. · 2019

Effective Connectivity Within the Default Mode Network in Left Temporal Lobe Epilepsy: Findings from the Epilepsy Connectome Project Open

Cole J. Cook, Gyujoon Hwang, Jedidiah Mathis, Veena A. Nair, Lisa L. Conant , et al. · 2018

The Epilepsy Connectome Project examines the differences in connectomes between temporal lobe epilepsy (TLE) patients and healthy controls. Using these data, the effective connectivity of the default mode network (DMN) in patients with lef…

Multiple Regions of a Cortical Network Commonly Encode the Meaning of Words in Multiple Grammatical Positions of Read Sentences Open

Andrew Anderson, Edmund C. Lalor, Feng Lin, Jeffrey R. Binder, Leonardo Fernandino , et al. · 2018

Deciphering how sentence meaning is represented in the brain remains a major challenge to science. Semantically related neural activity has recently been shown to arise concurrently in distributed brain regions as successive words in a sen…

The Neural Basis of Successful Word Reading in Aphasia Open

Sara B. Pillay, William L. Gross, William W. Graves, Colin Humphries, Diane Book , et al. · 2017

Understanding the neural basis of recovery from stroke is a major research goal. Many functional neuroimaging studies have identified changes in brain activity in people with aphasia, but it is unclear whether these changes truly support s…

Lesion localization of speech comprehension deficits in chronic aphasia Open

Sara B. Pillay, Jeffrey R. Binder, Colin Humphries, William L. Gross, Diane Book · 2017

Damage to the mid-to-posterior MTG is associated with an inability to integrate multiword utterances during comprehension of spoken language. Impairment of this integration process likely underlies the speech comprehension deficits charact…

Heteromodal Cortical Areas Encode Sensory-Motor Features of Word Meaning Open

Leonardo Fernandino, Colin Humphries, Lisa L. Conant, Mark S. Seidenberg, Jeffrey R. Binder · 2016

The capacity to process information in conceptual form is a fundamental aspect of human cognition, yet little is known about how this type of information is encoded in the brain. Although the role of sensory and motor cortical areas has be…

Predicting Neural Activity Patterns Associated with Sentences Using a Neurobiologically Motivated Model of Semantic Representation Open

Andrew Anderson, Jeffrey R. Binder, Leonardo Fernandino, Colin Humphries, Lisa L. Conant , et al. · 2016

We introduce an approach that predicts neural representations of word meanings contained in sentences then superposes these to predict neural representations of new sentences. A neurobiological semantic model based on sensory, motor, socia…

Surface errors without semantic impairment in acquired dyslexia: a voxel-based lesion–symptom mapping study Open

Jeffrey R. Binder, Sara B. Pillay, Colin Humphries, William L. Gross, William W. Graves , et al. · 2016

Patients with surface dyslexia have disproportionate difficulty pronouncing irregularly spelled words (e.g. pint), suggesting impaired use of lexical-semantic information to mediate phonological retrieval. Patients with this deficit also m…

Predicting brain activation patterns associated with individual lexical concepts based on five sensory-motor attributes Open

Leonardo Fernandino, Colin Humphries, Mark S. Seidenberg, William L. Gross, Lisa L. Conant , et al. · 2015

Concept Representation Reflects Multimodal Abstraction: A Framework for Embodied Semantics Open

Leonardo Fernandino, Jeffrey R. Binder, Rutvik H. Desai, Suzanne L. Pendl, Colin Humphries , et al. · 2015

Recent research indicates that sensory and motor cortical areas play a significant role in the neural representation of concepts. However, little is known about the overall architecture of this representational system, including the role p…

The implementation of the Objective Structured Practical Examination (OSPE) method: Students’ and examiners’ experiences Open

Benita Olivier, Vaneshveri Naidoo, Witness Mudzi, Heleen van Aswegen, Joanne Potterton , et al. · 2015

Background. Traditionally, physiotherapy practical skills have been assessed by a method that relies on the subjective interpretation of competency by the examiner and lacks the formative benefits of assessment. Objective. To describe and …

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