Colin M. Fitzsimmons
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View article: Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like expression in Schistosoma haematobium and Schistosoma mansoni infection
Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like expression in Schistosoma haematobium and Schistosoma mansoni infection Open
Schistosoma haematobium is the most prevalent of the human-infecting schistosome species, causing significant morbidity in endemically exposed populations. Despite this, it has been relatively understudied compared to its fellow species, S…
View article: Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like protein expression in<i>Schistosoma haematobium</i>and<i>Schistosoma mansoni</i>infection
Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like protein expression in<i>Schistosoma haematobium</i>and<i>Schistosoma mansoni</i>infection Open
Schistosoma haematobium is the most prevalent of the human-infecting schistosome species, causing significant morbidity in endemically exposed populations. Despite this, it has been relatively understudied compared to its fellow species, S…
View article: Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity
Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity Open
Allergic reactions can be considered as maladaptive IgE immune responses towards environmental antigens. Intriguingly, these mechanisms are observed to be very similar to those implicated in the acquisition of an important degree of immuni…
View article: Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment
Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment Open
BACKGROUND: The heptalaminate-covered, syncytial tegument is an important anatomical adaptation that enables schistosome parasites to maintain long-term, intravascular residence in definitive hosts. Investigation of the proteins present in…
View article: Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection
Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection Open
The IgE response has been associated with both allergic reactions and immunity to metazoan parasites. Recently, we hypothesized that all environmental allergens bear structural homology to IgE-binding antigens from metazoan parasites and t…