Colin R. MacKenzie
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View article: Early-life gut microbiome and stress-axis perturbations dysregulate the development of systemic, mucosal, and brain immunity
Early-life gut microbiome and stress-axis perturbations dysregulate the development of systemic, mucosal, and brain immunity Open
View article: Impaired systemic antibody response against gut microbiota pathobionts in critical illness and susceptibility to nosocomial infections
Impaired systemic antibody response against gut microbiota pathobionts in critical illness and susceptibility to nosocomial infections Open
Critically ill patients in intensive care units (ICUs) experience high rates of nosocomial infections, commonly caused by translocation and dissemination of pathogenic microorganisms that colonize the intestinal tract (pathobionts). Multip…
View article: Correction: Scharf et al. Oxford Nanopore Technology-Based Identification of an Acanthamoeba castellanii Endosymbiosis in Microbial Keratitis. Microorganisms 2024, 12, 2292
Correction: Scharf et al. Oxford Nanopore Technology-Based Identification of an Acanthamoeba castellanii Endosymbiosis in Microbial Keratitis. Microorganisms 2024, 12, 2292 Open
There was an error in the original publication [...]
View article: Mechanical compression induces neuronal apoptosis, reduces synaptic activity, and promotes glial neuroinflammation in mice and humans
Mechanical compression induces neuronal apoptosis, reduces synaptic activity, and promotes glial neuroinflammation in mice and humans Open
Mass effect, characterized by the compression and deformation of neural tissue from space-occupying lesions, can lead to debilitating neurological symptoms and poses a significant clinical challenge. In the primary brain tumor glioblastoma…
View article: (004) “YOU NEVER KNOW WHAT IT LOOKS LIKE, UNTIL YOU LOOK AT IT”: PATIENT DEPICTIONS OF FEMALE GENITAL ANATOMY
(004) “YOU NEVER KNOW WHAT IT LOOKS LIKE, UNTIL YOU LOOK AT IT”: PATIENT DEPICTIONS OF FEMALE GENITAL ANATOMY Open
Introduction In recent years, there has been a growing interest in how patients employ health literacy, including basic anatomy knowledge, to navigate the health care system and communicate effectively with providers. Some empirical data s…
View article: Copernicus Sentinel-3 OLCI Level-1B Radiometry Product Validation Status After Six Years in Constellation by Three Independent Expert Groups
Copernicus Sentinel-3 OLCI Level-1B Radiometry Product Validation Status After Six Years in Constellation by Three Independent Expert Groups Open
As part of the Copernicus program of the European Union (EU), the European Space Agency (ESA) and the European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT) are currently operating the Sentinel-3 mission that co…
View article: Early-life gut microbiome and stress-axis perturbations dysregulate systemic, mucosal, and brain immunity
Early-life gut microbiome and stress-axis perturbations dysregulate systemic, mucosal, and brain immunity Open
Background Early-life disruptions to the gut microbiome and stress-axis significantly influence the development of immune, neuroendocrine, and other physiological systems. However, the precise microbial species and pathways mediating these…
View article: Oxford Nanopore Technology-Based Identification of an Acanthamoeba castellanii Endosymbiosis in Microbial Keratitis
Oxford Nanopore Technology-Based Identification of an Acanthamoeba castellanii Endosymbiosis in Microbial Keratitis Open
(1) Background: Microbial keratitis is a serious eye infection that carries a significant risk of vision loss. Acanthamoeba spp. are known to cause keratitis and their bacterial endosymbionts can increase virulence and/or treatment resista…
View article: Clinical Outcome Patterns of Use of Radium-223 in Patients with Metastatic Castration-Resistant Prostate Cancer
Clinical Outcome Patterns of Use of Radium-223 in Patients with Metastatic Castration-Resistant Prostate Cancer Open
Introduction: Radium-223 dichloride (radium-223) is a bone-targeting radioisotope therapy that aids in the survival of patients with metastatic castration-resistant prostate cancer (mCRPC) to bones. This study aimed to describe the clinica…
View article: Case report—Depression with psychotic features as an atypical presentation of neurosyphilis
Case report—Depression with psychotic features as an atypical presentation of neurosyphilis Open
Key Clinical Message Recurrent depression with psychotic features is an atypical presentation of neurosyphilis. This case emphasizes the polymorphic clinical presentation of neurosyphilis and how it mimics affective disorders with psychoti…
View article: Infectious Complications in Patients with Myelodysplastic Syndromes: A Report from the Düsseldorf MDS Registry
Infectious Complications in Patients with Myelodysplastic Syndromes: A Report from the Düsseldorf MDS Registry Open
Despite notable advancements in infection prevention and treatment, individuals with hematologic malignancies still face the persistent threat of frequent and life-threatening complications. Those undergoing chemotherapy or other disease-m…
View article: Pneumonia outbreaks due to re-emergence of Mycoplasma pneumoniae
Pneumonia outbreaks due to re-emergence of Mycoplasma pneumoniae Open
View article: Mycoplasma pneumoniae: delayed re-emergence after COVID-19 pandemic restrictions
Mycoplasma pneumoniae: delayed re-emergence after COVID-19 pandemic restrictions Open
Mycoplasma pneumoniae is a common cause of respiratory tract infections with community-acquired pneumonia as the major disease-related burden. Compared with other pathogens, M pneumoniae is atypical in many ways: it is one of the smallest …
View article: Disseminated Cryptococcosis Is a Common Finding among Human Immunodeficiency Virus-Infected Patients with Suspected Sepsis and Is Associated with Higher Mortality Rates
Disseminated Cryptococcosis Is a Common Finding among Human Immunodeficiency Virus-Infected Patients with Suspected Sepsis and Is Associated with Higher Mortality Rates Open
Cryptococcosis is the leading cause of death among people with HIV in Sub-Saharan Africa. The lack of optimum diagnoses and medications significantly impair the management of the disease. We investigated the burden of cryptococcosis and re…
View article: Early oral switch in low-risk <i>Staphylococcus aureus</i> bloodstream infection
Early oral switch in low-risk <i>Staphylococcus aureus</i> bloodstream infection Open
Background Staphylococcus aureus bloodstream infection (SAB) is treated with at least 14 days of intravenously administered antimicrobials. We assessed the efficacy and safety of an early oral switch therapy in patients at low risk for SAB…
View article: Mycoplasma pneumoniae: gone forever?
Mycoplasma pneumoniae: gone forever? Open
View article: Case report - Depression with psychotic features as an atypical presentation of neurosyphilis
Case report - Depression with psychotic features as an atypical presentation of neurosyphilis Open
View article: Cryptococcal Infection Is the Leading Cause of Death among HIV-Infected Sepsis Patients in Central Ethiopia
Cryptococcal Infection Is the Leading Cause of Death among HIV-Infected Sepsis Patients in Central Ethiopia Open
Cryptococcosis is a leading cause of death among people with HIV in sub-Saharan Africa. Limited diagnostic and therapeutic options significantly impair treatment options in Africa. We investigated the burden of cryptococcosis and related m…
View article: Teicoplanin-Resistant Coagulase-Negative Staphylococci: Do the Current Susceptibility Testing Methods Reliably Detect This Elusive Phenotype?
Teicoplanin-Resistant Coagulase-Negative Staphylococci: Do the Current Susceptibility Testing Methods Reliably Detect This Elusive Phenotype? Open
Coagulase-negative staphylococci (CoNS), members of the skin commensal microbiota, are increasingly associated with local or systemic infections due to a shift in patient populations in recent decades. Subsequently, more CoNS strains have …
View article: Impact of implementation of polymerase chain reaction on diagnosis, treatment, and clinical course of Acanthamoeba keratitis
Impact of implementation of polymerase chain reaction on diagnosis, treatment, and clinical course of Acanthamoeba keratitis Open
Purpose Acanthamoeba keratitis (AK) is a painful and possibly sight-threatening ocular infection. While the correct diagnosis and specific treatment in the early stages significantly improve the prognosis, the disease is often misdiagnosed…
View article: Cytokine Hyperresponsiveness in Children With ETV6::RUNX1-positive Acute Lymphoblastic Leukemia After Challenge With Common Pathogens
Cytokine Hyperresponsiveness in Children With ETV6::RUNX1-positive Acute Lymphoblastic Leukemia After Challenge With Common Pathogens Open
Contains fulltext : 290882.pdf (Publisher’s version ) (Open Access)
View article: P644: Can computational tools generate greater than ACMG supporting evidence? A circularity-free analysis using ATM, CHEK2, and breast cancer case-control data
P644: Can computational tools generate greater than ACMG supporting evidence? A circularity-free analysis using ATM, CHEK2, and breast cancer case-control data Open
View article: Diagnostik und Therapie organischer intraorbitaler Fremdkörper
Diagnostik und Therapie organischer intraorbitaler Fremdkörper Open
Zusammenfassung Hintergrund Orbitaverletzungen mit organischen Fremdkörpern sind eine klinische Herausforderung, da sie eine Vielzahl von Komplikationen verursachen können und manchmal zu irreversiblen Visuseinschränkungen führen. Material…
View article: TPACK Towards ICT Integration: Does Creativity Have a Moderating Effect?
TPACK Towards ICT Integration: Does Creativity Have a Moderating Effect? Open
The purpose of this study was to examine an effect of technological pedagogical and content knowledge (TPACK) on information and communication technology (ICT) integration in Indonesia with moderated by creativity. The data for this …
View article: Mycoplasma pneumoniae beyond the COVID-19 pandemic: where is it?
Mycoplasma pneumoniae beyond the COVID-19 pandemic: where is it? Open
Mycoplasma pneumoniae is a major bacterial cause of respiratory tract infection.1Waites KB Talkington DF Mycoplasma pneumoniae and its role as a human pathogen.Clin Microbiol Rev. 2004; 17: 697-728Crossref PubMed Scopus (926) Google Schola…
View article: Spectrum and resistance in bacterial infections of the ocular surface in a German tertiary referral center 2009–2019
Spectrum and resistance in bacterial infections of the ocular surface in a German tertiary referral center 2009–2019 Open
Purpose Aim of this study was to evaluate the frequencies, trends, and antibiotic resistance of bacteria collected from ocular surface or contact lens material in a German tertiary referral center from 2009 to 2019. Methods Microbiological…
View article: P321: PERTURBATIONS IN STIMULUS-INDUCED CYTOKINE RESPONSES IN CHILDREN WITH BCP-ALL
P321: PERTURBATIONS IN STIMULUS-INDUCED CYTOKINE RESPONSES IN CHILDREN WITH BCP-ALL Open
Background: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common subtype of childhood leukemia with a peak during early childhood when children are exposed to viral infections. About 5% of all newborns carry a preleuk…
View article: Characterization of the cagA-gene in Helicobacter pylori in Mongolia and detection of two EPIYA-A enriched CagA types
Characterization of the cagA-gene in Helicobacter pylori in Mongolia and detection of two EPIYA-A enriched CagA types Open
Helicobacter pylori infection is strongly associated with gastritis, gastroduodenal ulcer disease and gastric carcinoma. The virulence of H. pylori strains increases with the presence of the pathogenicity island PAI, which encodes a Type 4…
View article: Prevalence and characterization of antimicrobial resistance among gram-negative bacteria isolated from febrile hospitalized patients in central Ethiopia
Prevalence and characterization of antimicrobial resistance among gram-negative bacteria isolated from febrile hospitalized patients in central Ethiopia Open
View article: Detection of invasive Trichosporon asahii in patient blood by a fungal PCR array
Detection of invasive Trichosporon asahii in patient blood by a fungal PCR array Open
Rare invasive fungal infections are increasingly emerging in hosts with predisposing factors such as immunodeficiency. Their timely diagnosis remains difficult, as their clinical picture may initially mimic infections with more common fung…