Colin W. Taylor
YOU?
Author Swipe
View article: Dual regulation of IP3 receptors by IP3 and PIP2 controls the transition from local to global Ca2+ signals
Dual regulation of IP3 receptors by IP3 and PIP2 controls the transition from local to global Ca2+ signals Open
The spatial organization of inositol 1,4,5-trisphosphate (IP3)-evoked Ca2+ signals underlies their versatility. Low stimulus intensities evoke Ca2+ puffs, localized Ca2+ signals arising from a fe…
View article: KRAP regulates mitochondrial Ca2+ uptake by licensing IP3 receptor activity and stabilizing ER–mitochondrial junctions
KRAP regulates mitochondrial Ca2+ uptake by licensing IP3 receptor activity and stabilizing ER–mitochondrial junctions Open
Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) are high-conductance channels that allow the regulated redistribution of Ca2+ from the endoplasmic reticulum (ER) to the cytosol and, at specialized membrane contact sites (MCSs), to oth…
View article: Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+
Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+ Open
Loss of endoplasmic reticular (ER) Ca 2+ activates store-operated Ca 2+ entry (SOCE) by causing the ER localized Ca 2+ sensor STIM to unfurl domains that activate Orai channels in the plasma membrane at membrane contact sites (MCS). Here, …
View article: Dissociation of inositol 1,4,5-trisphosphate from IP3 receptors contributes to termination of Ca2+ puffs
Dissociation of inositol 1,4,5-trisphosphate from IP3 receptors contributes to termination of Ca2+ puffs Open
Ca2+ puffs are brief, localized Ca2+ signals evoked by physiological stimuli that arise from the coordinated opening of a few clustered inositol 1,4,5-trisphosphate receptors (IP3Rs). However, the mechanisms that control the amplitude and …
View article: Author response: Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+
Author response: Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+ Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Loss of…
View article: Regulation of Store-Operated Ca <sup>2+</sup> Entry by IP <sub>3</sub> Receptors Independent of Their Ability to Release Ca <sup>2+</sup>
Regulation of Store-Operated Ca <sup>2+</sup> Entry by IP <sub>3</sub> Receptors Independent of Their Ability to Release Ca <sup>2+</sup> Open
Loss of endoplasmic reticular (ER) Ca 2+ activates store-operated Ca 2+ entry (SOCE) by causing the ER localized Ca 2+ sensor STIM to unfurl domains that activate Orai channels in the plasma membrane at membrane contact sites (MCS). Here w…
View article: iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2
iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2 Open
View article: Quantal Ca2+ release mediated by very few IP3 receptors that rapidly inactivate allows graded responses to IP3
Quantal Ca2+ release mediated by very few IP3 receptors that rapidly inactivate allows graded responses to IP3 Open
View article: P2X4 Receptors Mediate Ca2+ Release from Lysosomes in Response to Stimulation of P2X7 and H1 Histamine Receptors
P2X4 Receptors Mediate Ca2+ Release from Lysosomes in Response to Stimulation of P2X7 and H1 Histamine Receptors Open
The P2X4 purinergic receptor is targeted to endolysosomes, where it mediates an inward current dependent on luminal ATP and pH. Activation of P2X4 receptors was previously shown to trigger lysosome fusion, but the regulation of P2X4 recept…
View article: KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals
KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals Open
View article: The store-operated Ca <sup>2+</sup> entry complex comprises a small cluster of STIM1 associated with one Orai1 channel
The store-operated Ca <sup>2+</sup> entry complex comprises a small cluster of STIM1 associated with one Orai1 channel Open
Significance Store-operated Ca 2+ entry (SOCE) links Ca 2+ release from endoplasmic reticulum (ER) to Ca 2+ entry across the plasma membrane (PM). SOCE is unusual in requiring interaction between proteins in different membranes. STIM1, whe…
View article: Regulation of Store-Operated Ca <sup>2+</sup> Entry by IP <sub>3</sub> Receptors Independent of Their Ability to Release Ca <sup>2+</sup>
Regulation of Store-Operated Ca <sup>2+</sup> Entry by IP <sub>3</sub> Receptors Independent of Their Ability to Release Ca <sup>2+</sup> Open
View article: Ca2+ Release by IP3 Receptors Is Required to Orient the Mitotic Spindle
Ca2+ Release by IP3 Receptors Is Required to Orient the Mitotic Spindle Open
View article: Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of <scp>d</scp>-<i>myo</i>-Inositol 1,4,5-Trisphosphate Receptors
Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of <span>d</span>-<i>myo</i>-Inositol 1,4,5-Trisphosphate Receptors Open
d-myo-Inositol 1,4,5-trisphosphate receptors (IP3Rs) are Ca2+ channels activated by the intracellular messenger inositol 1,4,5-trisphosphate (IP3, 1). The glyconucleotide adenophostin A (AdA, …
View article: IP3 receptors and their intimate liaisons
IP3 receptors and their intimate liaisons Open
View article: Professor Sir Michael Berridge FRS (1938–2020)
Professor Sir Michael Berridge FRS (1938–2020) Open
View article: Both <scp>d</scp>- and <scp>l</scp>-Glucose Polyphosphates Mimic <scp>d</scp>-<i>myo</i>-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P<sub>3</sub> Receptor
Both <span>d</span>- and <span>l</span>-Glucose Polyphosphates Mimic <span>d</span>-<i>myo</i>-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P<sub>3</sub> Receptor Open
Chiral sugar derivatives are potential cyclitol surrogates of the Ca2+-mobilizing intracellular messenger d-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]. Six novel polyphosphorylated analogues derived from b…
View article: Decision letter: IP3 mediated global Ca2+ signals arise through two temporally and spatially distinct modes of Ca2+ release
Decision letter: IP3 mediated global Ca2+ signals arise through two temporally and spatially distinct modes of Ca2+ release Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The ‘building-block’ model of inositol tri…
View article: Reliable measurement of free Ca2+ concentrations in the ER lumen using Mag-Fluo-4
Reliable measurement of free Ca2+ concentrations in the ER lumen using Mag-Fluo-4 Open
View article: <scp>d</scp>-<i>chiro</i>-Inositol Ribophostin: A Highly Potent Agonist of <scp>d</scp>-<i>myo</i>-Inositol 1,4,5-Trisphosphate Receptors: Synthesis and Biological Activities
<span>d</span>-<i>chiro</i>-Inositol Ribophostin: A Highly Potent Agonist of <span>d</span>-<i>myo</i>-Inositol 1,4,5-Trisphosphate Receptors: Synthesis and Biological Activities Open
Analogues of the Ca2+-releasing intracellular messenger d-myo-inositol 1,4,5-trisphosphate [1, Ins(1,4,5)P3] are important synthetic targets. Replacement of the α-glucopyranosyl motif in the natural prod…
View article: Decision letter: ER-luminal [Ca2+] regulation of InsP3 receptor gating mediated by an ER-luminal peripheral Ca2+-binding protein
Decision letter: ER-luminal [Ca2+] regulation of InsP3 receptor gating mediated by an ER-luminal peripheral Ca2+-binding protein Open
View article: Golgi anti-apoptotic proteins are evolutionarily conserved ion channels that regulate cell death in plants
Golgi anti-apoptotic proteins are evolutionarily conserved ion channels that regulate cell death in plants Open
Programmed cell death regulates developmental and stress responses in eukaryotes. Golgi anti-apoptotic proteins (GAAPs) are evolutionarily conserved cell death regulators. Human and viral GAAPs inhibit apoptosis and modulate intracellular …
View article: Analyses of Ligand Binding to IP3 Receptors Using Fluorescence Polarization
Analyses of Ligand Binding to IP3 Receptors Using Fluorescence Polarization Open
View article: A genetically encoded toolkit of functionalized nanobodies against fluorescent proteins for visualizing and manipulating intracellular signalling
A genetically encoded toolkit of functionalized nanobodies against fluorescent proteins for visualizing and manipulating intracellular signalling Open
View article: Remodeling of ER–plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca <sup>2+</sup> influx in mitosis
Remodeling of ER–plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca <sup>2+</sup> influx in mitosis Open
Significance The mechanisms blocking Ca 2+ influx in mitosis are complex and involve a decrease in stable endoplasmic reticulum (ER)–plasma membrane (PM) contact sites and degradation of the ER Ca 2+ sensor stromal interaction molecule 1 (…
View article: Structure and Function of IP<sub>3</sub>Receptors
Structure and Function of IP<sub>3</sub>Receptors Open
Inositol 1,4,5-trisphosphate receptors (IP3Rs), by releasing Ca2+ from the endoplasmic reticulum (ER) of animal cells, allow Ca2+ to be redistributed from the ER to the cytosol or other organelles, and they…
View article: A genetically-encoded toolkit of functionalized nanobodies against fluorescent proteins for visualizing and manipulating intracellular signalling
A genetically-encoded toolkit of functionalized nanobodies against fluorescent proteins for visualizing and manipulating intracellular signalling Open
Background Intrabodies enable targeting of proteins in live cells, but it remains a huge task to generate specific intrabodies against the thousands of proteins in a proteome. We leverage the widespread availability of fluorescently labell…
View article: GPN does not release lysosomal Ca2+ but evokes Ca2+ release from the ER by increasing the cytosolic pH independently of cathepsin C
GPN does not release lysosomal Ca2+ but evokes Ca2+ release from the ER by increasing the cytosolic pH independently of cathepsin C Open
The dipeptide glycyl-l-phenylalanine 2-naphthylamide (GPN) is widely used to perturb lysosomes because its cleavage by the lysosomal enzyme cathepsin C is proposed to rupture lysosomal membranes. We show that GPN evokes a sustained increas…
View article: Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors
Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors Open
View article: A synthetic cyclitol-nucleoside conjugate polyphosphate is a highly potent second messenger mimic
A synthetic cyclitol-nucleoside conjugate polyphosphate is a highly potent second messenger mimic Open
A densely functionalised phosphorylatedchiro-inositol-nucleoside ether conjugate constructed from cyclic fragments is the most potent IP3receptor ligand discovered.