Colin W. Wright
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View article: Computational Insight into the Intercalating Properties of Cryptolepine
Computational Insight into the Intercalating Properties of Cryptolepine Open
DNA is held together by hydrogen bonding between nucleobases (adenine-thymine, guanine-cytosine) and van der Waals interactions between adjacent base pairs' π orbitals. Intercalating molecules with quasiplanar structures utilize van der Wa…
View article: Therapeutic Resolution of Pulmonary Arterial Hypertension (PAH) Using Natural Products
Therapeutic Resolution of Pulmonary Arterial Hypertension (PAH) Using Natural Products Open
Pulmonary arterial hypertension (PAH) is a progressive and rare condition characterised by the occlusion of pulmonary arterioles, with clinical manifestations resulting from the cross-sectional area reduction of the small pulmonary arterie…
View article: Machine learning enhances prediction of plants as potential sources of antimalarials
Machine learning enhances prediction of plants as potential sources of antimalarials Open
Plants are a rich source of bioactive compounds and a number of plant-derived antiplasmodial compounds have been developed into pharmaceutical drugs for the prevention and treatment of malaria, a major public health challenge. However, ide…
View article: Additional file 3 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Additional file 3 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer Open
Additional file 3: Table S2. Somatic mutations in urinary bladder canine UC.
View article: Additional file 5 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Additional file 5 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer Open
Additional file 5: Table S4. Somatic mutations in urinary bladder bovine UC.
View article: Additional file 1 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Additional file 1 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer Open
Additional file 1: Table S1. Clinical details of the patients in the study.
View article: Additional file 22 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Additional file 22 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer Open
Additional file 22: Table S10. Germline variants in urinary bladder feline UC.
View article: Additional file 21 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Additional file 21 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer Open
Additional file 21: Table S9. Germline variants in urinary bladder canine UC.
View article: Additional file 4 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Additional file 4 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer Open
Additional file 4: Table S3. Somatic mutations in urinary bladder feline UC.
View article: Additional file 23 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Additional file 23 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer Open
Additional file 23: Table S11. Germline variants in urinary bladder bovine UC.
View article: Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer
Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer Open
The prospect of eradicating malaria continues to be challenging in the face of increasing parasite resistance to antimalarial drugs so that novel antimalarials active against asexual, sexual, and liver-stage malaria parasites are urgently …
View article: CCDC 2155900: Experimental Crystal Structure Determination
CCDC 2155900: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2155899: Experimental Crystal Structure Determination
CCDC 2155899: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: An Efficient Method for the Isolation of Toxins from Pteridium aquilinum and Evaluation of Ptaquiloside Against Cancer and Non-cancer Cells
An Efficient Method for the Isolation of Toxins from Pteridium aquilinum and Evaluation of Ptaquiloside Against Cancer and Non-cancer Cells Open
The common fern, bracken (Pteridium aquilinum), is well known for its toxic effects on livestock due principally to the carcinogenic constituent ptaquiloside ( 1), although other toxins are present including the cyanogenic glycoside, pruna…
View article: Evaluation of <i>Alangium lamarckii</i> Bark for Antiplasmodial and Cytotoxic Constituents and Isolation of a Novel Tubulosine Analogue
Evaluation of <i>Alangium lamarckii</i> Bark for Antiplasmodial and Cytotoxic Constituents and Isolation of a Novel Tubulosine Analogue Open
Alangium lamarkii is traditionally used in India for the treatment of malaria. Partial activity guided-fractionation of the basic chloroform fraction of the methanolic extract of the bark led to the isolation of a novel tubulosine analogue…
View article: Issue Information
Issue Information Open
No abstract is available for this article.
View article: 202 Therapeutic resolution of pulmonary arterial hypertension (pah) by novel small molecule natural products
202 Therapeutic resolution of pulmonary arterial hypertension (pah) by novel small molecule natural products Open
Heterozygous germline mutations in the gene encoding type II bone morphogenetic protein receptor (BMPRII) underlie the majority (~80%) of the familial form of pulmonary arterial hypertension (HPAH). 1 PAH is a devastating cardiovascular di…
View article: Codata Data Citation Workshop, South Africa: Presentations
Codata Data Citation Workshop, South Africa: Presentations Open
Presentations from the workshop on Data Citation held on 10 December 2015 at the CSIR, Pretoria, South Africa. This workshop was convened by as part of an international series of workshops organised by the CODATA Task Group on Data Citatio…