William H Colledge
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View article: Hypothalamic control of puberty: from neuronal circuits to mechanisms for its metabolic regulation
Hypothalamic control of puberty: from neuronal circuits to mechanisms for its metabolic regulation Open
The hypothalamus is a singular brain region with essential roles in the control of a wide diversity of vegetative functions, from growth and energy balance to reproduction. These processes are governed by interconnected neuroendocrine path…
View article: Estrogen-Regulated Lateral Septal Kisspeptin Neurons Abundantly Project to GnRH Neurons and the Hypothalamic Supramammillary Nucleus
Estrogen-Regulated Lateral Septal Kisspeptin Neurons Abundantly Project to GnRH Neurons and the Hypothalamic Supramammillary Nucleus Open
While hypothalamic kisspeptin (KP) neurons play well-established roles in the estrogen-dependent regulation of reproduction, little is known about extrahypothalamic KP-producing (KP LS ) neurons of the lateral septum. As established previo…
View article: Neuronal plasticity at puberty in hypothalamic neurons controlling fertility in female mice
Neuronal plasticity at puberty in hypothalamic neurons controlling fertility in female mice Open
Puberty is a critical transition period to achieve fertility and reproductive capacity in all mammalian species. At puberty, the hypothalamic-pituitary-gonadal (HPG) is activated by neuroendocrine changes in the brain. Central to this are …
View article: Kisspeptin signaling in astrocytes modulates the reproductive axis
Kisspeptin signaling in astrocytes modulates the reproductive axis Open
Reproduction is safeguarded by multiple, often cooperative, regulatory networks. Kisspeptin signaling, via KISS1R, plays a fundamental role in reproductive control, primarily by regulation of hypothalamic GnRH neurons. We disclose herein a…
View article: <scp>GnRH</scp> pulse generator frequency is modulated by kisspeptin and <scp>GABA</scp> ‐glutamate interactions in the posterodorsal medial amygdala in female mice
<span>GnRH</span> pulse generator frequency is modulated by kisspeptin and <span>GABA</span> ‐glutamate interactions in the posterodorsal medial amygdala in female mice Open
Kisspeptin neurons in the arcuate nucleus of the hypothalamus generate gonadotrophin‐releasing hormone (GnRH) pulses, and act as critical initiators of functional gonadotrophin secretion and reproductive competency. However, kisspeptin in …
View article: Estrogen differentially regulates transcriptional landscapes of preoptic and arcuate kisspeptin neuron populations
Estrogen differentially regulates transcriptional landscapes of preoptic and arcuate kisspeptin neuron populations Open
Kisspeptin neurons residing in the rostral periventricular area of the third ventricle (KP RP3V ) and the arcuate nucleus (KP ARC ) mediate positive and negative estrogen feedback, respectively. Here, we aim to compare transcriptional resp…
View article: Transcriptome profiling of kisspeptin neurons from the mouse arcuate nucleus reveals new mechanisms in estrogenic control of fertility
Transcriptome profiling of kisspeptin neurons from the mouse arcuate nucleus reveals new mechanisms in estrogenic control of fertility Open
Kisspeptin neurons in the mediobasal hypothalamus (MBH) are critical targets of ovarian estrogen feedback regulating mammalian fertility. To reveal molecular mechanisms underlying this signaling, we thoroughly characterized the estrogen-re…
View article: GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice
GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice Open
Kisspeptin neurons in the arcuate nucleus of the hypothalamus generate GnRH pulses, and act as critical initiators of functional gonadotrophin secretion, and reproductive competency. However, kisspeptin in other brain regions, most notably…
View article: Sexually Dimorphic Neurosteroid Synthesis Regulates Neuronal Activity in the Murine Brain.
Sexually Dimorphic Neurosteroid Synthesis Regulates Neuronal Activity in the Murine Brain. Open
Sex steroid hormones act on hypothalamic kisspeptin neurons to regulate reproductive neural circuits in the brain. Kisspeptin neurons start to express estrogen receptors in utero, suggesting steroid hormone action on these cells early duri…
View article: Additional file 5 of The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent
Additional file 5 of The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent Open
Additional file 5:Supplemental Table 1. The characteristics and probe locations of the outliers from the volcano plots representing the Affymetrix results. (XLS 75 KB)
View article: Additional file of The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent
Additional file of The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent Open
Additional file of The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent
View article: Optogenetic stimulation of kisspeptin neurones within the posterodorsal medial amygdala increases luteinising hormone pulse frequency in female mice
Optogenetic stimulation of kisspeptin neurones within the posterodorsal medial amygdala increases luteinising hormone pulse frequency in female mice Open
Kisspeptin within the arcuate nucleus of the hypothalamus is a critical neuropeptide in the regulation of reproduction. Together with neurokinin B and dynorphin A, arcuate kisspeptin provides the oscillatory activity that drives the pulsat…
View article: Sexually dimorphic gene expression and neurite sensitivity to estradiol in fetal arcuate Kiss1 cells
Sexually dimorphic gene expression and neurite sensitivity to estradiol in fetal arcuate Kiss1 cells Open
Kiss1 neurons of the arcuate (ARC) nucleus form an interconnected network of cells that communicate via neurokinin B (encoded by Tac2 ) and its receptor (encoded by Tacr3 ) and play key roles in the control of the reproductive axis through…
View article: Faculty Opinions recommendation of Eavesdropping grey squirrels infer safety from bird chatter.
Faculty Opinions recommendation of Eavesdropping grey squirrels infer safety from bird chatter. Open
When multiple species are vulnerable to a common set of predators, it is advantageous for individuals to recognize information about the environment provided by other species.Eastern gray squirrels (Sciurus carolinensis) and other small ma…
View article: Optogenetic stimulation of kisspeptin neurones within the posterodorsal medial amygdala increases LH pulse frequency in female mice
Optogenetic stimulation of kisspeptin neurones within the posterodorsal medial amygdala increases LH pulse frequency in female mice Open
Kisspeptin within the arcuate nucleus of the hypothalamus is a critical neuropeptide in the regulation of reproduction. Together with neurokinin and dynorphin A, arcuate kisspeptin provides the oscillatory activity that drives the pulsatil…
View article: Editorial: The Multiple Facets of Kisspeptin Activity in Biological Systems
Editorial: The Multiple Facets of Kisspeptin Activity in Biological Systems Open
EDITORIAL article Front. Endocrinol., 03 December 2018Sec. Experimental Endocrinology Volume 9 - 2018 | https://doi.org/10.3389/fendo.2018.00727
View article: Sex‐ and sub region‐dependent modulation of arcuate kisspeptin neurones by vasopressin and vasoactive intestinal peptide
Sex‐ and sub region‐dependent modulation of arcuate kisspeptin neurones by vasopressin and vasoactive intestinal peptide Open
A population of kisspeptin neurones located in the hypothalamic arcuate nucleus ( ARN ) very likely represent the gonadotrophin‐releasing hormone pulse generator responsible for driving pulsatile luteinising hormone secretion in mammals. A…
View article: The Role of Kiss1 Neurons As Integrators of Endocrine, Metabolic, and Environmental Factors in the Hypothalamic–Pituitary–Gonadal Axis
The Role of Kiss1 Neurons As Integrators of Endocrine, Metabolic, and Environmental Factors in the Hypothalamic–Pituitary–Gonadal Axis Open
Kisspeptin-GPR54 signaling in the hypothalamus is required for reproduction and fertility in mammals. Kiss1 neurons are key regulators of gonadotropin-releasing hormone (GnRH) release and modulation of the hypothalamic-pituitary-gonadal (H…
View article: Correction: Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo
Correction: Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo Open
[This corrects the article DOI: 10.1371/journal.pone.0176821.].
View article: Definition of the hypothalamic GnRH pulse generator in mice
Definition of the hypothalamic GnRH pulse generator in mice Open
Significance Neural networks located in the hypothalamus are responsible for generating ultradian patterns of hormone secretion that control a wide variety of functions. How these neural networks generate pulsatile hormone secretion remain…
View article: Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo
Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo Open
Kisspeptins regulate the mammalian reproductive axis by stimulating release of gonadotrophin releasing hormone (GnRH). Different length kisspeptins (KP) are found of 54, 14, 13 or 10 amino-acids which share a common C-terminal 10-amino aci…
View article: Transforming growth factor β receptor inhibition prevents ventricular fibrosis in a mouse model of progressive cardiac conduction disease
Transforming growth factor β receptor inhibition prevents ventricular fibrosis in a mouse model of progressive cardiac conduction disease Open
Myocardial fibrosis secondary to a loss of NaV1.5 is triggered by TGF-β signalling pathway. Those events are more likely secondary to the decreased NaV1.5 sarcolemmal expression rather than the decreased Na+ current per se. TGF-β receptor …
View article: Visualisation of <i>Kiss1</i> Neurone Distribution Using a Kiss1‐<scp>CRE</scp> Transgenic Mouse
Visualisation of <i>Kiss1</i> Neurone Distribution Using a Kiss1‐<span>CRE</span> Transgenic Mouse Open
Kisspeptin neuropeptides are encoded by the Kiss1 gene and play a critical role in the regulation of the mammalian reproductive axis. Kiss1 neurones are found in two locations in the rodent hypothalamus: one in the arcuate nucleus ( ARC ) …
View article: Evidence of kisspeptin receptor expression in GnRH neurons in the preoptic area and arcuate hypothalamic nuclei in cycling buffaloes
Evidence of kisspeptin receptor expression in GnRH neurons in the preoptic area and arcuate hypothalamic nuclei in cycling buffaloes Open
Our previous study reported the expression of kisspeptin in the preoptic area (POA) and arcuate nucleus (ARC) of the hypothalamus of cycling buffalo cows. In ruminants, POA and ARC are the main hypothalamic nuclei through which kisspeptin …
View article: <i>Mfsd14a</i> ( <i>Hiat1</i> ) gene disruption causes globozoospermia and infertility in male mice
<i>Mfsd14a</i> ( <i>Hiat1</i> ) gene disruption causes globozoospermia and infertility in male mice Open
The Mfsd14a gene, previously called Hiat1, encodes a transmembrane protein of unknown function with homology to the solute carrier protein family. To study the function of the MFSD14A protein, mutant mice (Mus musculus, strain 129S6Sv/Ev) …