Colleen C. Nelson
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View article: Network based simultaneous embedding of cells and marker genes from scRNA-seq studies
Network based simultaneous embedding of cells and marker genes from scRNA-seq studies Open
The complexity of scRNA-sequencing datasets highlights the urgent need for enhanced clustering and visualization methods. Here, we propose Stardust, an iterative, force-directed graph layout algorithm that enables the simultaneous embeddin…
View article: Author response: Artificial intelligence driven tumor risk stratification from single-cell transcriptomics using phenotype algebra
Author response: Artificial intelligence driven tumor risk stratification from single-cell transcriptomics using phenotype algebra Open
View article: Artificial intelligence driven tumor risk stratification from single-cell transcriptomics using phenotype algebra
Artificial intelligence driven tumor risk stratification from single-cell transcriptomics using phenotype algebra Open
Single-cell RNA-sequencing (scRNA-seq) coupled with robust computational analysis facilitates the characterization of phenotypic heterogeneity within tumors. Current scRNA-seq analysis pipelines are capable of identifying a myriad of malig…
View article: SCellBOW: AI-Driven Tumor Risk Stratification from Single-Cell Transcriptomics Using Phenotype Algebra
SCellBOW: AI-Driven Tumor Risk Stratification from Single-Cell Transcriptomics Using Phenotype Algebra Open
Single-cell RNA-sequencing (scRNA-seq) coupled with robust computational analysis facilitates the characterization of phenotypic heterogeneity within tumors. Current scRNA-seq analysis pipelines are capable of identifying a myriad of malig…
View article: Author response: SCellBOW: AI-Driven Tumor Risk Stratification from Single-Cell Transcriptomics Using Phenotype Algebra
Author response: SCellBOW: AI-Driven Tumor Risk Stratification from Single-Cell Transcriptomics Using Phenotype Algebra Open
View article: Artificial intelligence driven tumor risk stratification from single-cell transcriptomics using phenotype algebra
Artificial intelligence driven tumor risk stratification from single-cell transcriptomics using phenotype algebra Open
Single-cell RNA-sequencing (scRNA-seq) coupled with robust computational analysis facilitates the characterization of phenotypic heterogeneity within tumors. Current scRNA-seq analysis pipelines are capable of identifying a myriad of malig…
View article: Pseudo-grading of tumor subpopulations from single-cell transcriptomic data using Phenotype Algebra
Pseudo-grading of tumor subpopulations from single-cell transcriptomic data using Phenotype Algebra Open
Single-cell RNA-sequencing (scRNA-seq) coupled with robust computational analysis facilitates the characterization of phenotypic heterogeneity within tumors. Current scRNA-seq analysis pipelines are capable of identifying a myriad of malig…
View article: Author response: Pseudo-grading of tumor subpopulations from single-cell transcriptomic data using Phenotype Algebra
Author response: Pseudo-grading of tumor subpopulations from single-cell transcriptomic data using Phenotype Algebra Open
View article: Targeting valine catabolism to inhibit metabolic reprogramming in prostate cancer
Targeting valine catabolism to inhibit metabolic reprogramming in prostate cancer Open
View article: Valine Catabolism Drives Bioenergetic and Lipogenic Fuel Plasticity in Prostate Cancer
Valine Catabolism Drives Bioenergetic and Lipogenic Fuel Plasticity in Prostate Cancer Open
Metabolic reprogramming is a hallmark of cancer and fundamental for disease progression. The remodelling of oxidative phosphorylation and enhanced lipogenesis are key characteristics of prostate cancer (PCa). Recently, succinate-dependent …
View article: Patient-reported outcomes before treatment for localized prostate cancer: are there differences among countries? Data from the True North Global Registry
Patient-reported outcomes before treatment for localized prostate cancer: are there differences among countries? Data from the True North Global Registry Open
Introduction Similar Patient-Reported Outcomes (PROs) at diagnosis for localized prostate cancer among countries may indicate that different treatments are recommended to the same profile of patients, regardless the context characteristics…
View article: Unravelling the Role of Iroquois Homeobox 4 and its Interplay with Androgen Receptor in Prostate Cancer
Unravelling the Role of Iroquois Homeobox 4 and its Interplay with Androgen Receptor in Prostate Cancer Open
View article: Introduction of Androgen Receptor Targeting shRNA Inhibits Tumor Growth in Patient-Derived Prostate Cancer Xenografts
Introduction of Androgen Receptor Targeting shRNA Inhibits Tumor Growth in Patient-Derived Prostate Cancer Xenografts Open
Patient-derived xenograft (PDX) models have been established as important preclinical cancer models, overcoming some of the limitations associated with the use of cancer cell lines. The utility of prostate cancer PDX models has been limite…
View article: Supplementary Information from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells
Supplementary Information from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells Open
Supplementary Figures S1â^'S9 and figures legends Supplementary Tables S1â^'S6 Supplementary Videos S1â^'S5 and legends
View article: Supplementary Figures 1-3 from Clusterin Is a Critical Downstream Mediator of Stress-Induced YB-1 Transactivation in Prostate Cancer
Supplementary Figures 1-3 from Clusterin Is a Critical Downstream Mediator of Stress-Induced YB-1 Transactivation in Prostate Cancer Open
PDF file - 160K
View article: Supplementary Video S3. Interphase microtubule dynamics in HeLa-EB1-GFP treated with DMSO. from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells
Supplementary Video S3. Interphase microtubule dynamics in HeLa-EB1-GFP treated with DMSO. from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells Open
EB1-GFP was imaged by spinning disk microscopy (1 image/s for 1 min). EB1 comets were clearly discernible and followed regular trajectories. Scale bar=10 µm.
View article: Supplementary Data from Clusterin Facilitates COMMD1 and I-κB Degradation to Enhance NF-κB Activity in Prostate Cancer Cells
Supplementary Data from Clusterin Facilitates COMMD1 and I-κB Degradation to Enhance NF-κB Activity in Prostate Cancer Cells Open
Supplementary Data from Clusterin Facilitates COMMD1 and I-κB Degradation to Enhance NF-κB Activity in Prostate Cancer Cells
View article: Supplementary Figures 1-3 from Clusterin Is a Critical Downstream Mediator of Stress-Induced YB-1 Transactivation in Prostate Cancer
Supplementary Figures 1-3 from Clusterin Is a Critical Downstream Mediator of Stress-Induced YB-1 Transactivation in Prostate Cancer Open
PDF file - 160K
View article: Supplementary Video S2.Time-lapse microscopy of HeLa-H2B-GFP cells treated with 6-AA (2.5, 5 and 10 nM). from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells
Supplementary Video S2.Time-lapse microscopy of HeLa-H2B-GFP cells treated with 6-AA (2.5, 5 and 10 nM). from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells Open
HeLa-H2B-GFP cells were imaged using an Olympus IX81 (1 image/5 min for 24 h). Top panels: brightfield, bottom panels: GFP channel. 6-AA increased in a concentration-dependent manner mitotic duration, leading to cell death or asymmetric di…
View article: Supplemental Files from Lipid Uptake Is an Androgen-Enhanced Lipid Supply Pathway Associated with Prostate Cancer Disease Progression and Bone Metastasis
Supplemental Files from Lipid Uptake Is an Androgen-Enhanced Lipid Supply Pathway Associated with Prostate Cancer Disease Progression and Bone Metastasis Open
Figure S1: LNCaP, VCaP and DuCaP cells were grown in charcoal-dextran stripped serum (CSS) for 48 h and treated with increasing concentrations of R1881 or DHT in the presence or absence of Enzalutamide (10 µM) or vehicle (Ctrl) for 48 h. F…
View article: Data from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells
Data from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells Open
The lack of a cure for metastatic castrate-resistant prostate cancer (mCRPC) highlights the urgent need for more efficient drugs to fight this disease. Here, we report the mechanism of action of the natural product 6α-acetoxyanopterine (6-…
View article: Supplementary Video S5. Interphase microtubule dynamics in HeLa-EB1-GFP treated with vinblastine (20 nM). from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells
Supplementary Video S5. Interphase microtubule dynamics in HeLa-EB1-GFP treated with vinblastine (20 nM). from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells Open
EB1-GFP was imaged by spinning disk microscopy (2 images/s for 2 min). EB1 comets appeared faint and followed irregular and short trajectories. Scale bar=10 µm.
View article: Supplementary Data from Lipid Uptake Is an Androgen-Enhanced Lipid Supply Pathway Associated with Prostate Cancer Disease Progression and Bone Metastasis
Supplementary Data from Lipid Uptake Is an Androgen-Enhanced Lipid Supply Pathway Associated with Prostate Cancer Disease Progression and Bone Metastasis Open
Supplementary Figures
View article: Supplementary Data from Clusterin Facilitates COMMD1 and I-κB Degradation to Enhance NF-κB Activity in Prostate Cancer Cells
Supplementary Data from Clusterin Facilitates COMMD1 and I-κB Degradation to Enhance NF-κB Activity in Prostate Cancer Cells Open
Supplementary Data from Clusterin Facilitates COMMD1 and I-κB Degradation to Enhance NF-κB Activity in Prostate Cancer Cells
View article: Data from Lipid Uptake Is an Androgen-Enhanced Lipid Supply Pathway Associated with Prostate Cancer Disease Progression and Bone Metastasis
Data from Lipid Uptake Is an Androgen-Enhanced Lipid Supply Pathway Associated with Prostate Cancer Disease Progression and Bone Metastasis Open
De novo lipogenesis is a well-described androgen receptor (AR)–regulated metabolic pathway that supports prostate cancer tumor growth by providing fuel, membrane material, and steroid hormone precursor. In contrast, our current unde…
View article: Supplementary Information from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells
Supplementary Information from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells Open
Supplementary Figures S1â^'S9 and figures legends Supplementary Tables S1â^'S6 Supplementary Videos S1â^'S5 and legends
View article: Supplementary Video S2.Time-lapse microscopy of HeLa-H2B-GFP cells treated with 6-AA (2.5, 5 and 10 nM). from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells
Supplementary Video S2.Time-lapse microscopy of HeLa-H2B-GFP cells treated with 6-AA (2.5, 5 and 10 nM). from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells Open
HeLa-H2B-GFP cells were imaged using an Olympus IX81 (1 image/5 min for 24 h). Top panels: brightfield, bottom panels: GFP channel. 6-AA increased in a concentration-dependent manner mitotic duration, leading to cell death or asymmetric di…
View article: Data from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells
Data from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells Open
The lack of a cure for metastatic castrate-resistant prostate cancer (mCRPC) highlights the urgent need for more efficient drugs to fight this disease. Here, we report the mechanism of action of the natural product 6α-acetoxyanopterine (6-…
View article: Supplementary Data from Lipid Uptake Is an Androgen-Enhanced Lipid Supply Pathway Associated with Prostate Cancer Disease Progression and Bone Metastasis
Supplementary Data from Lipid Uptake Is an Androgen-Enhanced Lipid Supply Pathway Associated with Prostate Cancer Disease Progression and Bone Metastasis Open
Supplementary Figures
View article: Supplementary Video S1.Time-lapse microscopy of HeLa-H2B-GFP cells treated with DMSO, vinblastine (20 nM) or 6-AA (0.62 nM). from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells
Supplementary Video S1.Time-lapse microscopy of HeLa-H2B-GFP cells treated with DMSO, vinblastine (20 nM) or 6-AA (0.62 nM). from 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells Open
HeLa-H2B-GFP cells were imaged using an Olympus IX81 (1 image/5 min for 24 h). Top panels: brightfield, bottom panels: H2B-GFP. DMSO-treated cells normally progressed through mitosis, which was delayed with vinblastine (20 nM) and low dose…