Colleen E. Harty
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View article: Conditional antagonism in co-cultures of Pseudomonas aeruginosa and Candida albicans: An intersection of ethanol and phosphate signaling distilled from dual-seq transcriptomics
Conditional antagonism in co-cultures of Pseudomonas aeruginosa and Candida albicans: An intersection of ethanol and phosphate signaling distilled from dual-seq transcriptomics Open
Pseudomonas aeruginosa and Candida albicans are opportunistic pathogens whose interactions involve the secreted products ethanol and phenazines. Here, we describe the role of ethanol in mixed-species co-cultures by dual-seq analyses. P. ae…
View article: Pseudomonas aeruginosa Ethanol Oxidation by AdhA in Low-Oxygen Environments
Pseudomonas aeruginosa Ethanol Oxidation by AdhA in Low-Oxygen Environments Open
Ethanol is a common product of microbial fermentation, and the Pseudomonas aeruginosa response to and utilization of ethanol are relevant to our understanding of its role in microbial communities. Here, we report that the putative alcohol …
View article: <i>Pseudomonas aeruginosa</i>ethanol oxidation by AdhA in low oxygen environments
<i>Pseudomonas aeruginosa</i>ethanol oxidation by AdhA in low oxygen environments Open
Pseudomonas aeruginosa has a broad metabolic repertoire that facilitates its co-existence with different microbes. Many microbes secrete products that P. aeruginosa can then catabolize, including ethanol, a common fermentation product. Her…
View article: Ethanol Decreases Pseudomonas aeruginosa Flagellar Motility through the Regulation of Flagellar Stators
Ethanol Decreases Pseudomonas aeruginosa Flagellar Motility through the Regulation of Flagellar Stators Open
Ethanol is an important biologically active molecule produced by many bacteria and fungi. It has also been identified as a potential marker for disease state in cystic fibrosis. In line with previous data showing that ethanol promotes biof…
View article: Ethanol Stimulates Trehalose Production through a SpoT-DksA-AlgU-Dependent Pathway in Pseudomonas aeruginosa
Ethanol Stimulates Trehalose Production through a SpoT-DksA-AlgU-Dependent Pathway in Pseudomonas aeruginosa Open
Pseudomonas aeruginosa is often found with bacteria and fungi that produce fermentation products, including ethanol. At concentrations similar to those produced by environmental microbes, we found that ethanol stimulated expression of treh…
View article: Ethanol stimulates trehalose production through a SpoT-DksA-AlgU dependent pathway in<i>Pseudomonas aeruginosa</i>
Ethanol stimulates trehalose production through a SpoT-DksA-AlgU dependent pathway in<i>Pseudomonas aeruginosa</i> Open
Pseudomonas aeruginosa frequently resides among ethanol-producing microbes, making its response to these microbially-produced concentrations of ethanol relevant to understanding its biology. Our ranscriptome analysis found that the genes i…
View article: Ethanol decreases <i>Pseudomonas aeruginosa</i> flagellar motility through a cyclic-di-GMP- and stator-dependent pathway
Ethanol decreases <i>Pseudomonas aeruginosa</i> flagellar motility through a cyclic-di-GMP- and stator-dependent pathway Open
Pseudomonas aeruginosa frequently encounters microbes that produce bioactive metabolites including ethanol. At concentrations that do not affect growth, we found that ethanol reduces P. aeruginosa motility by 30% in a swim agar assay and t…
View article: Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways
Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways Open
Candida albicans is both a major fungal pathogen and a member of the commensal human microflora. The morphological switch from yeast to hyphal growth is associated with disease and many environmental factors are known to influence the yeas…