Colleen Loo
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View article: Real-world clinical data on the long-term effectiveness and safety of generic racemic ketamine treatment
Real-world clinical data on the long-term effectiveness and safety of generic racemic ketamine treatment Open
Ketamine is a highly effective treatment for difficult-to-treat or treatment-resistant depression (TRD). The commercially developed intranasal spray containing S-ketamine has demonstrated short and long-term efficacy and safety in phase 3 …
View article: DNA methylation changes in a pharmaco-epigenomic EWAS in depression: comparing fixed and response-guided dosing paradigms for ketamine in the KADS trial
DNA methylation changes in a pharmaco-epigenomic EWAS in depression: comparing fixed and response-guided dosing paradigms for ketamine in the KADS trial Open
DNA methylation is a dynamic biomarker suited to investigate processes, e.g., treatment response. We investigate DNA methylation changes in different dosing paradigms for ketamine (s.c.) vs. midazolam (s.c.) in treatment resistant depresse…
View article: Cranial Sutures Alter Computational Models of Transcranial Electrical Stimulation
Cranial Sutures Alter Computational Models of Transcranial Electrical Stimulation Open
Background ROAST (Realistic vOlumetric-Approach-based Simulator for Transcranial electric stimulation) has been increasingly utilized to inform studies of transcranial electrical stimulation (tES). The precision of ROAST is dependent on an…
View article: Assessing Neuromodulation Effects of Theta Burst Stimulation to the Prefrontal Cortex Using Transcranial Magnetic Stimulation Electroencephalography (TMS‐EEG)
Assessing Neuromodulation Effects of Theta Burst Stimulation to the Prefrontal Cortex Using Transcranial Magnetic Stimulation Electroencephalography (TMS‐EEG) Open
Theta burst stimulation (TBS), a form of repetitive transcranial magnetic stimulation (TMS), is capable of non‐invasively modulating cortical excitability. TBS is gaining popularity as a therapeutic tool for psychiatric disorders such as d…
View article: A Computational Modeling Study of Focal Electrically Administered Seizure Therapy and Frontoparietal Electroconvulsive Therapy
A Computational Modeling Study of Focal Electrically Administered Seizure Therapy and Frontoparietal Electroconvulsive Therapy Open
Objectives Modification of the electrode placement with electroconvulsive therapy (ECT) impacts on patient outcomes, including cognitive effects. The investigation of alternative right unilateral placements (RUL) has the potential to furth…
View article: It is time to reassess reporting of electroconvulsive therapy data in New Zealand: A 17-year retrospective analysis of treatment data from Waikato
It is time to reassess reporting of electroconvulsive therapy data in New Zealand: A 17-year retrospective analysis of treatment data from Waikato Open
Objective: The New Zealand Government has provided brief annual reports on electroconvulsive therapy treatment since 2004. Despite this, only limited information is made available to clinicians to guide clinical improvement and refine guid…
View article: Effect of ketamine on anxiety: findings from the Ketamine for Adult Depression Study
Effect of ketamine on anxiety: findings from the Ketamine for Adult Depression Study Open
Background Anxiety disorders and treatment-resistant major depressive disorder (TRD) are often comorbid. Studies suggest ketamine has anxiolytic and antidepressant properties. Aims To investigate if subcutaneous racemic ketamine, delivered…
View article: The Effect of Cranial Sutures Should Be Considered in Transcranial Electrical Stimulation
The Effect of Cranial Sutures Should Be Considered in Transcranial Electrical Stimulation Open
Background Computational modeling is used to optimize transcranial electrical stimulation (tES) approaches, and the precision of these models is dependent on their anatomical accuracy. We are unaware of any computational modeling of tES th…
View article: Effects of repetitive transcranial magnetic stimulation combined with cognitive training for improving response inhibition: A proof-of-concept, single-blind randomised controlled study
Effects of repetitive transcranial magnetic stimulation combined with cognitive training for improving response inhibition: A proof-of-concept, single-blind randomised controlled study Open
This first proof of concept study did not find evidence that four sessions of active rTMS + CT could induce cognitive or neurophysiological effects on response inhibition in healthy participants. However, subgroup analyses suggests that rT…
View article: Relapse Following Electroconvulsive Therapy for Schizophrenia: A Systematic Review and Meta-analysis
Relapse Following Electroconvulsive Therapy for Schizophrenia: A Systematic Review and Meta-analysis Open
Background Evidence regarding schizophrenia relapse following acute electroconvulsive therapy (ECT) is sparse compared with that for depression, and we have no clear consensus on relapse proportions. We aimed to provide longitudinal inform…
View article: The effects of treatment, clinical and demographic factors on recovery of orientation after ECT: A care network study
The effects of treatment, clinical and demographic factors on recovery of orientation after ECT: A care network study Open
This large-scale retrospective, real-world study showed that recovery of orientation after ECT was most affected by ECT type, though age, gender, and baseline level cognitive impairment also affected outcomes. These findings can inform the…
View article: Clinical Outcomes of Electroconvulsive Therapy (ECT) for Depression in Older Old People Relative to Other Age Groups Across the Adult Life Span: A CARE Network Study
Clinical Outcomes of Electroconvulsive Therapy (ECT) for Depression in Older Old People Relative to Other Age Groups Across the Adult Life Span: A CARE Network Study Open
Intervention Electroconvulsive therapy (ECT) is a commonly used treatment for severe psychiatric illness in older adults, including in the ‘older old’ population aged 80 years and above. However, there can sometimes be a reluctance to trea…
View article: Factors associated with electroconvulsive therapy treatment for adults with serious psychiatric conditions in Australia
Factors associated with electroconvulsive therapy treatment for adults with serious psychiatric conditions in Australia Open
Objective: To identify factors associated with receiving electroconvulsive therapy (ECT) for serious psychiatric conditions. Methods: Retrospective observational study using hospital administrative data linked with death registrations and …
View article: Extended-release ketamine tablets for treatment-resistant depression: a randomized placebo-controlled phase 2 trial
Extended-release ketamine tablets for treatment-resistant depression: a randomized placebo-controlled phase 2 trial Open
Ketamine has rapid-onset antidepressant activity in patients with treatment-resistant major depression (TRD). The safety and tolerability of racemic ketamine may be improved if given orally, as an extended-release tablet (R-107), compared …
View article: Prolonged intermittent theta burst stimulation targeting the left prefrontal cortex and cerebellum does not affect executive functions in healthy individuals
Prolonged intermittent theta burst stimulation targeting the left prefrontal cortex and cerebellum does not affect executive functions in healthy individuals Open
Repetitive transcranial magnetic stimulation (rTMS) for alleviating negative symptoms and cognitive dysfunction in schizophrenia commonly targets the left dorsolateral prefrontal cortex (LDLPFC). However, the therapeutic effectiveness of r…
View article: Royal Australian and New Zealand College of Psychiatrists professional practice guidelines for the administration of repetitive transcranial magnetic stimulation
Royal Australian and New Zealand College of Psychiatrists professional practice guidelines for the administration of repetitive transcranial magnetic stimulation Open
Objectives: To provide guidance for the optimal administration of repetitive transcranial magnetic stimulation, based on scientific evidence and supplemented by expert clinical consensus. Methods: Articles and information were sourced from…
View article: Individualised Transcranial Magnetic Stimulation Targeting of the Left Dorsolateral Prefrontal Cortex for Enhancing Cognition: A Randomised Controlled Trial
Individualised Transcranial Magnetic Stimulation Targeting of the Left Dorsolateral Prefrontal Cortex for Enhancing Cognition: A Randomised Controlled Trial Open
Repetitive transcranial magnetic stimulation (rTMS) has been demonstrated to produce cognitive enhancing effects across different neuropsychiatric disorders; however, so far, these effects have been limited. This trial investigated the eff…
View article: Cognitive outcomes from the randomised, active-controlled Ketamine for Adult Depression Study (KADS)
Cognitive outcomes from the randomised, active-controlled Ketamine for Adult Depression Study (KADS) Open
The findings support the cognitive safety of repeated fixed and escalating doses at least in the short-term in people with treatment resistant MDD.
View article: Prolonged Intermittent Theta Burst Stimulation Targeting the Left Prefrontal Cortex and Cerebellum Does Not Affect Executive Functions in Healthy Individuals
Prolonged Intermittent Theta Burst Stimulation Targeting the Left Prefrontal Cortex and Cerebellum Does Not Affect Executive Functions in Healthy Individuals Open
Repetitive transcranial magnetic stimulation (rTMS) for alleviating negative symptoms and cognitive dysfunction in schizophrenia commonly targets the left dorsolateral prefrontal cortex (LDLPFC). However, the therapeutic effectiveness of r…