Explanipedia

Integrated health checks as a person-centred approach to systematic screening of household tuberculosis contacts: A realist-informed mixed-methods study Open

Claire Calderwood, Edson Marambire, Modester Ngwerume, Maureen Tshuma, Mikaela Coleman , et al. · 2025

Globally, tuberculosis incidence and mortality is driven by syndemic interactions of tuberculosis with other chronic conditions including HIV, diabetes and undernutrition in a deleterious social and structural context, often characterised …

Evaluation of Tuberculosis Preventive Treatment Uptake Among People Living with HIV in PEPFAR-Supported Facilities in Zimbabwe Open

Collins Timire, Tawanda Mapuranga, Ronald Ncube, Talent Maphosa, Sithabiso Dube , et al. · 2025

Tuberculosis preventive treatment (TPT) reduces the incidence of tuberculosis (TB) among people living with HIV (PLHIV), but its coverage remains suboptimal in most settings. We conducted a cross-sectional study to describe TPT uptake amon…

TB disability and multimorbidity at the onset of treatment in Kenya, Uganda, Zambia and Zimbabwe Open

Susan Adakun, Fred Banda, Arnold Bloom, M. Bochnowicz, Jeremiah Chakaya , et al. · 2025

BACKGROUNDWe evaluated the practicality of integrating assessments on the burden of multimorbidity (including disability) and the effectiveness of referral pathways at the start of TB treatment across Kenya, Uganda, Zambia and Zimbabwe.MET…

Whole Genome Sequencing for Detecting Drug-Resistant Mutations in Mycobacterium tuberculosis in Zimbabwe Open

Beauty Makamure, David M. Ward, Tsitsi Bandason, Martha Chipinduro, Collins Timire , et al. · 2025

Background: Drug-resistant tuberculosis (DR-TB) is a major public health issue in Zimbabwe. Whole-genome-sequencing (WGS) is recommended for studying drug-resistant mutations, lineages, prevalence, and transmission patterns. However, there…

Treatment Outcomes of Tuberculosis Among Artisanal and Small-Scale Miners in Zimbabwe: A Follow-Up Observational Study Using Secondary Data Open

Dingani Moyo, Fungai Kavenga, Ronald Ncube, Florence Moyo, Nathan Chiboyiwa , et al. · 2024

In Zimbabwe, artisanal and small-scale miners (ASMs) are a key vulnerable group with high risk for tuberculosis (TB), HIV, and silicosis. The main purpose of this study was to investigate treatment outcomes of TB among ASMs. We conducted a…

Epidemiological profiles and outcomes of healthcare workers hospitalized for COVID-19 in five Sub-Saharan African countries: a cohort study Open

Tamba Mina Millimouno, Fassou Mathias Grovogui, Karifa Kourouma, Shermarke Hassan, Ibrahima Kaba , et al. · 2024

Background The COVID-19 pandemic placed immense strain on global health systems and healthcare workers (HCWs). This study aimed to analyze the epidemiological profiles and outcomes of HCWs hospitalized for COVID-19 across five sub-Saharan …

Higher loss of livelihood and impoverishment in households affected by tuberculosis compared to non-tuberculosis affected households in Zimbabwe: A cross-sectional study Open

Collins Timire, Rein M G J Houben, Debora Pedrazzoli, Rashida A. Ferrand, Claire Calderwood , et al. · 2024

Tuberculosis (TB) disproportionally affects poor people, leading to income and non-income losses. Measures of socioeconomic impact of TB, e.g. impoverishment and patient costs are inadequate to capture non-income losses. We applied impover…

Disability, comorbidities and risk determinants at end of TB treatment in Kenya, Uganda, Zambia and Zimbabwe Open

Susan Adakun, Fred Banda, Arnold Bloom, M. Bochnowicz, Jeremiah Chakaya , et al. · 2024

BACKGROUNDWe examined the feasibility of assessing and referring adults successfully completing TB treatment for comorbidities, risk determinants and disability in health facilities in Kenya, Uganda, Zambia and Zimbabwe.METHODSThis was a c…

Correction: Sexual violence against migrants and asylum seekers. The experience of the MSF clinic on Lesvos Island, Greece Open

Rea A. Belanteri, Sven Gudmund Hinderaker, Ewan Wilkinson, Maria Episkopou, Collins Timire , et al. · 2024

[This corrects the article DOI: 10.1371/journal.pone.0239187.].

Beyond tuberculosis: a person-centred and rights-based approach to screening for household contacts Open

Claire Calderwood, Collins Timire, Constancia Mavodza, Fungai Kavenga, Mxolisi Ngwenya , et al. · 2024

Households affected by tuberculosis have syndemic vulnerability, reflecting a concentration of and interactions between multiple biomedical, psychosocial, and structural determinants of health. Traditional approaches to tuberculosis screen…

Higher loss of livelihood and impoverishment in households affected by tuberculosis compared to non-tuberculosis affected households in Zimbabwe: a cross-sectional study Open

Collins Timire, Rein M G J Houben, Debora Pedrazzoli, Rashida A. Ferrand, Claire Calderwood , et al. · 2023

Introduction Tuberculosis (TB) disproportionally affects poor people, leading to income and non-income losses. Measures of socioeconomic impact of TB, e.g. impoverishment and patient costs are inadequate to capture non-income losses. We ap…

Knowledge, Attitudes, and Practices of Artisanal and Small-Scale Miners regarding Tuberculosis, Human Immunodeficiency Virus, and Silicosis in Zimbabwe Open

Dingani Moyo, Fungai Kavenga, Ronald Ncube, Farai Peter Macheri, Tariro Christwish Mando , et al. · 2023

In Zimbabwe, artisanal and small-scale miners (ASMs) have a high prevalence of tuberculosis (TB), human immunodeficiency virus (HIV), and silicosis. Previous studies on ASMs utilised programme data, and it was not possible to understand re…

Quality of Data Recording and Antimicrobial Use in a Municipal Veterinary Clinic in Ghana Open

Cletus Kubasari, Wisdom Adeapena, Robinah Najjemba, George Kwesi Hedidor, Raymond Lovelace Adjei , et al. · 2023

The recording of antimicrobial use data is critical for the development of interventions for the containment of antimicrobial resistance. This cross-sectional study assessed whether dissemination activities and recommendations made after a…

Assessing Changes in Bacterial Load and Antibiotic Resistance in the Legon Sewage Treatment Plant between 2018 and 2023 in Accra, Ghana Open

Raymond Lovelace Adjei, Lady Asantewah Boamah Adomako, Appiah Korang-Labi, F. K. Avornyo, Collins Timire , et al. · 2023

Wastewater treatment plants are efficient in reducing bacterial loads but are also considered potential drivers of environmental antimicrobial resistance (AMR). In this study, we determined the effect of increased influent wastewater volum…

Time to Treatment and Risk Factors for Unsuccessful Treatment Outcomes among People Who Started Second-Line Treatment for Rifampicin-Resistant or Multi-Drug-Resistant Tuberculosis in the Kyrgyz Republic, 2021 Open

Bolot Kyrbashov, Aizat Kulzhabaeva, Abdullaat Kadyrov, Atyrkul Toktogonova, Collins Timire , et al. · 2023

The Kyrgyz Republic is a high-burden country for rifampicin resistant/multi-drug resistant tuberculosis (RR/MDR-TB). TB control efforts rely on early diagnosis and initiation of people on effective regimens. We studied the interval from di…

Coping with drug resistant tuberculosis alongside COVID-19 and other stressors in Zimbabwe: A qualitative study Open

Collins Timire, Katharina Kranzer, Debora Pedrazzoli, Fungai Kavenga, Samuel Kasozi , et al. · 2023

Households in low-resource settings are more vulnerable to events which adversely affect their livelihoods, including shocks e.g. death of family members, droughts and more recently COVID-19. Drug Resistant Tuberculosis (DR-TB) is another …

Use of a Sustainable Livelihood Framework–Based Measure to Estimate Socioeconomic Impact of Tuberculosis on Households Open

Collins Timire, Debora Pedrazzoli, Delia Boccia, Rein M G J Houben, Rashida A. Ferrand , et al. · 2023

Tuberculosis (TB) disproportionally affects impoverished members of society. The adverse socioeconomic impact of TB on households is mostly measured using money-centric approaches, which have been criticized as one-dimensional and risk eit…

Bloodstream infections and antibiotic resistance at a regional hospital, Colombia, 2019–2021 Open

Julio C. Saavedra, Deisy Fonseca, Arpine Abrahamyan, Pruthu Thekkur, Collins Timire , et al. · 2023

Objectives. To assess antibiotic susceptibility of World Health Organization (WHO) priority bacteria (Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Salmonella spp., Staphylococcus aureus, and Streptococcus pneumoniae) …

Coping with drug resistant tuberculosis alongside COVID-19 and other stressors in Zimbabwe: a qualitative study Open

Collins Timire, Katharina Kranzer, Debora Pedrazzoli, Fungai Kavenga, Samuel Kasozi , et al. · 2023

Background Households in low-resource settings are more vulnerable to events which adversely affect their livelihoods, including shocks such as the death of a family member, inflation, droughts and more recently COVID-19. Drug Resistant Tu…

Coverage and effectiveness of conditional cash transfer for people with drug resistant tuberculosis in Zimbabwe: A mixed methods study Open

Collins Timire, Charles Sandy, Rashida A. Ferrand, Regina Mubau, Peter Shiri , et al. · 2022

The End TB strategy recommends social protection to mitigate socio-economic impacts of tuberculosis. Zimbabwe started implementing a conditional cash transfer (CCT) programme for people on drug resistant tuberculosis (DR-TB) treatment in 2…

The Triple Burden of Tuberculosis, Human Immunodeficiency Virus and Silicosis among Artisanal and Small-Scale Miners in Zimbabwe Open

Dingani Moyo, Ronald Ncube, Fungai Kavenga, Lilian Chikwava, Tawanda Mapuranga , et al. · 2022

Artisanal and small-scale mining is characterized by an excessive exposure to silica-containing dust, overcrowding, poor living conditions and limited access to primary health services. This poses a risk to tuberculosis, HIV infection and …

Pattern of Antimicrobial Susceptibility and Antimicrobial Treatment of Neonates Admitted with Suspected Sepsis in a Teaching Hospital in Ghana, 2021 Open

Kwaku Anim Omenako, Anthony Enimil, Afia Frimpomaa Asare Marfo, Collins Timire, Palanivel Chinnakali , et al. · 2022

Neonatal sepsis is a life-threatening emergency, and empirical antimicrobial prescription is common. In this cross-sectional study of neonates admitted with suspected sepsis in a teaching hospital in Ghana from January–December 2021, we de…

Sepsis among Neonates in a Ghanaian Tertiary Military Hospital: Culture Results and Turnaround Times Open

Francis Tetteh, Raymond D. Fatchu, Kingsley Ackah, Trudy Janice Philips, Hemant Deepak Shewade , et al. · 2022

In this study, we described the bacterial profile, antibiotic resistance pattern, and laboratory result turnaround time (TAT) in neonates with suspected sepsis from a tertiary-level, military hospital in Accra, Ghana (2017–2020). This was …

Coverage and effectiveness of conditional cash transfer for people with drug resistant tuberculosis in Zimbabwe: a mixed methods study Open

Collins Timire, Charles Sandy, Rashida A. Ferrand, Regina Mubau, Peter Shiri , et al. · 2022

Background The End TB strategy recommends social protection to mitigate socio-economic impacts of tuberculosis. Zimbabwe started implementing a conditional cash transfer (CCT) programme for people on drug resistant tuberculosis (DR-TB) tre…

Performance of an Emergency Road Ambulance Service in Bhutan: Response Time, Utilization, and Outcomes Open

Tshokey Tshokey, Ugyen Tshering, Karma Lhazeen, Arpine Abrahamyan, Collins Timire , et al. · 2022

Background: An efficient ambulance service is a vital component of emergency medical services. We determined the emergency ambulance response and transport times and ambulance exit outcomes in Bhutan. Methods: A cross-sectional study invol…

An Update on the Surveillance of Livestock Diseases and Antimicrobial Use in Sierra Leone in 2021—An Operational Research Study Open

Fatmata Isatu Bangura, Amara Leno, Katrina Hann, Collins Timire, Divya Nair , et al. · 2022

In Sierra Leone, in 2020, a study by the Livestock and Veterinary Services Division (Ministry of Agriculture and Forestry) on the surveillance system of animal diseases and antimicrobial use found poor reporting. Of the expected weekly dis…

Pesticide Importation in Sierra Leone, 2010–2021: Implications for Food Production and Antimicrobial Resistance Open

Raymonda Johnson, Katrina Hann, Amara Leno, Collins Timire, Alpha J. A. Bangura , et al. · 2022

There are no previous studies reporting the type and quantity of pesticides for farming from Sierra Leone and the impact of Ebola or COVID-19 on importation. This study reviewed imported farming pesticides by the Sierra Leone, Ministry of …

Retention and performance of peer educators and sustainability of HIV prevention services for adolescents in the Zimbabwe Smart-LyncAges project: an ecological study Open

Simbarashe Mabaya, Ronald Ncube, Hannock Tweya, Collins Timire, Jeffrey K. Edwards , et al. · 2022

sustained uptake of services was possibly due to heightened awareness of service availability and demand generation in the first year of implementation. Peer-led interventions are effective for health information dissemination. Monetary in…

TB prevalence in Zimbabwe: a national cross-sectional survey, 2014 Open

Martha Chipinduro, Collins Timire, Joconiah Chirenda, Ronnie Matambo, Ellen Munemo , et al. · 2021

BACKGROUND: We conducted the first national TB prevalence survey to provide accurate estimates of bacteriologically confirmed pulmonary TB disease among adults aged ≥15 years in 2014. METHODS: A TB symptoms screen and chest X-ray (CXR) wer…

Effects of repeated blood donation on iron status of blood donors in Zimbabwe: A cross‐sectional study Open

Donald Vhanda, Frank Chinowaita, Sisodwa Zamani Nkomo, Collins Timire, Vinie Kouamou · 2021

Introduction Iron deficiency is a major complication of repeated blood donation. However, most of the blood screening methods employed by blood collection agents do not include iron status markers, leading to possible subclinical iron defi…

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