Colton J. F. Watson
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View article: GSK3 inhibition improves skeletal muscle function and whole-body metabolism in male mouse models of Duchenne muscular dystrophy
GSK3 inhibition improves skeletal muscle function and whole-body metabolism in male mouse models of Duchenne muscular dystrophy Open
View article: An Animal Model for Muscular Flap Donor Site Morbidity: Ablation of Soleus and Gastrocnemius in Mice Results in Antagonistic Tibialis Anterior Muscle Atrophy:
An Animal Model for Muscular Flap Donor Site Morbidity: Ablation of Soleus and Gastrocnemius in Mice Results in Antagonistic Tibialis Anterior Muscle Atrophy: Open
Background: The creation of an animal model to understanding muscle flap donor site morbidity after free tissue transfer is needed. There is a paucity in the literature identifying biomechanical and molecular mechanisms of skeletal muscle …
View article: Toward countering muscle and bone loss with spaceflight: GSK3 as a potential target
Toward countering muscle and bone loss with spaceflight: GSK3 as a potential target Open
View article: Kynurenine metabolism is altered in <i>mdx</i> mice: a potential muscle to brain connection
Kynurenine metabolism is altered in <i>mdx</i> mice: a potential muscle to brain connection Open
New Findings What is the central question in this study? Promoting muscle health with regular aerobic exercise can improve mental health through a kynurenine metabolic pathway: do conditions of muscle disease such as muscular dystrophy neg…
View article: Kynurenine metabolism is altered in <i>mdx</i> mice: a potential muscle to brain connection
Kynurenine metabolism is altered in <i>mdx</i> mice: a potential muscle to brain connection Open
Regular exercise can direct muscle kynurenine (KYN) metabolism toward the neuroprotective branch of the kynurenine pathway thereby limiting the accumulation of neurotoxic metabolites in the brain and contributing to mental resilience. Whil…
View article: Amplified detection of nucleic acids and proteins using an isothermal proximity CRISPR Cas12a assay
Amplified detection of nucleic acids and proteins using an isothermal proximity CRISPR Cas12a assay Open
Herein, we develop an isothermal proximity CRISPR Cas12a assay that harnesses the target-induced collateral cleavage activity of Cas12a for the quantitative profiling of gene expression and detection of proteins with high sensitivity and s…
View article: GSK3 inhibition with low dose lithium supplementation augments murine muscle fatigue resistance and specific force production
GSK3 inhibition with low dose lithium supplementation augments murine muscle fatigue resistance and specific force production Open
Calcineurin is a Ca2+ -dependent serine/threonine phosphatase that dephosphorylates nuclear factor of activated T cells (NFAT), allowing for NFAT entry into the nucleus. In skeletal muscle, calcineurin signaling and NFAT activat…
View article: Low‐dose lithium feeding increases the SERCA2a‐to‐phospholamban ratio, improving SERCA function in murine left ventricles
Low‐dose lithium feeding increases the SERCA2a‐to‐phospholamban ratio, improving SERCA function in murine left ventricles Open
New Findings What is the central question of this study? Inhibition of glycogen synthase kinase‐3 (GSK3) has been shown to improve cardiac SERCA2a function. Lithium can inhibit GSK3, but therapeutic doses used in treating bipolar disorder …
View article: Inhibition of allergen-mediated mast cell activation by TAK1 inhibitor 5Z-7-oxozeaenol
Inhibition of allergen-mediated mast cell activation by TAK1 inhibitor 5Z-7-oxozeaenol Open
Introduction & Aim: Allergic inflammatory disorders are at epidemic levels worldwide. Mast cells drive this inappropriate immune response via release of a variety of pro-inflammatory mediators in response to environmental cues detected by …