Conan Chua
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View article: IL-2 produced by HBV-specific T cells as a biomarker of viral control and predictor of response to PD-1 therapy across clinical phases of chronic hepatitis B
IL-2 produced by HBV-specific T cells as a biomarker of viral control and predictor of response to PD-1 therapy across clinical phases of chronic hepatitis B Open
Background: There are no immunological biomarkers that predict control of chronic hepatitis B (CHB). The lack of immune biomarkers raises concerns for therapies targeting PD-1/PD-L1 because they have the potential for immune-related advers…
View article: Macrophages heterogeneity and significance during human fetal pancreatic development
Macrophages heterogeneity and significance during human fetal pancreatic development Open
SUMMARY Organogenesis is a complex process that relies on a dynamic interplay between extrinsic factors originating from the microenvironment and intrinsic factors specific to the tissue. For the endocrine cells of the islet of Langerhans,…
View article: Congenic hematopoietic stem cell transplantation promotes survival of heart allografts in murine models of acute and chronic rejection
Congenic hematopoietic stem cell transplantation promotes survival of heart allografts in murine models of acute and chronic rejection Open
The ability to induce tolerance would be a major advance in the field of solid organ transplantation. Here, we investigated whether autologous (congenic) hematopoietic stem cell transplantation (HSCT) could promote tolerance to heart allog…
View article: Liver-specific Inflammatory Signatures Predict Clinically Significant Liver Damage
Liver-specific Inflammatory Signatures Predict Clinically Significant Liver Damage Open
Background and Aims Inflammation drives progression of chronic liver disease. However, the triggers of inflammation remain undefined during chronic hepatitis B (CHB) because hepatic flares are spontaneous and difficult to capture. We used …
View article: Optimized ex vivo stimulation identifies multi-functional HBV-specific T cells in a majority of chronic hepatitis B patients
Optimized ex vivo stimulation identifies multi-functional HBV-specific T cells in a majority of chronic hepatitis B patients Open
High antigen burden during chronic hepatitis B (CHB) results in a low frequency HBV-specific T cell response with restricted functionality. However, this observation is based on limited data because low T cell frequencies have hindered eff…
View article: Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies Open
Autoantibodies, which are antibodies against self-antigens, are present in many disease states and can serve as markers for disease activity. The levels of autoantibodies to specific antigens are typically detected with the enzyme-linked i…