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AI-assisted design of ligands for lipocalin-2 Open
Introduction Lipocalin-2 (LCN2) is an acute-phase glycoprotein whose upregulation is associated with blood–brain-barrier breakdown and neuroinflammation, making it a potential diagnostic and therapeutic target. Methods We developed an end-…
AI assisted Design of Ligands for Lipocalin-2 Open
Lipocalin-2 (LCN2) is an acute-phase glycoprotein whose upregulation is linked to blood– brain-barrier breakdown and neuroinflammation, making it an attractive diagnostic and therapeutic target. We developed an end-to-end, AI-guided workfl…
TMX5/TXNDC15, a natural trapping mutant of the PDI family is a client of the proteostatic factor ERp44 Open
The ER is the organelle of nucleated cells that produces lipids, sugars, and proteins. More than 20 ER-resident members of the protein disulfide isomerase (PDI) family regulate formation, isomerization, and disassembly of covalent bonds in…
TMX5/TXNDC15, a natural trapping mutant of the PDI family is a client of the proteostatic factor ERp44 Open
The endoplasmic reticulum (ER) is the organelle of nucleated cells that produces lipids, sugars and proteins. More than 20 ER-resident members of the Protein Disulfide Isomerase (PDI) family regulate formation, isomerization and disassembl…
View article: Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages
Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages Open
The emergence of Omicron lineages and descendent subvariants continues to present a severe threat to the effectiveness of vaccines and therapeutic antibodies. We have previously suggested that an insufficient mucosal immunoglobulin A (IgA)…
Myc controls NK cell development, IL-15-driven expansion, and translational machinery Open
MYC is a pleiotropic transcription factor involved in cancer, cell proliferation, and metabolism. Its regulation and function in NK cells, which are innate cytotoxic lymphocytes important to control viral infections and cancer, remain poor…
View article: Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages
Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages Open
The emergence of Omicron lineages and descendent subvariants continues to present a severe threat to the effectiveness of vaccines and therapeutic antibodies. We have previously suggested that an insufficient mucosal IgA response induced b…
View article: Heterologous inactivated virus/mRNA vaccination response to BF.7, BQ.1.1, and XBB.1
Heterologous inactivated virus/mRNA vaccination response to BF.7, BQ.1.1, and XBB.1 Open
The emergence of highly immune-escape Omicron variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), such as BQ and XBB, has led to concerns about the efficacy of vaccines. Using lentivirus-based pseudovirus neutrali…
View article: Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein Open
Emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants diminishes the efficacy of vaccines and antiviral monoclonal antibodies. Continued development of immunotherapies and vaccine immunogens resilient to viral …
Myc controls IL-15-driven expansion and translational machinery of NK cells Open
Summary Myc is a pleiotropic transcription factor involved in cancer, cell proliferation, and metabolism. Its regulation and function in Natural Killer (NK) cells, which are innate cytotoxic lymphocytes important to control viral infection…
View article: Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2
Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2 Open
Emergence of SARS-CoV-2 variants diminishes the efficacy of vaccines and antiviral monoclonal antibodies. Continued development of immunotherapies and vaccine immunogens resilient to viral evolution is therefore necessary. Using coldspot-g…
<span>CEMIP</span> (<span>HYBID</span>, <span>KIAA1199</span>): structure, function and expression in health and disease Open
CEMIP (cell migration‐inducing protein), also known as KIAA1199 or HYBID, is a protein involved in the depolymerisation of hyaluronic acid (HA), a major glycosaminoglycan component of the extracellular matrix. CEMIP was originally describe…
Thioredoxin-Related Transmembrane Proteins: TMX1 and Little Brothers TMX2, TMX3, TMX4 and TMX5 Open
The endoplasmic reticulum (ER) is site of synthesis and maturation of membrane and secretory proteins in eukaryotic cells. The ER contains more than 20 members of the Protein Disulfide Isomerase (PDI) family. These enzymes regulate formati…
Eat it right: ER-phagy and recovER-phagy Open
The endoplasmic reticulum (ER) is the site of protein, lipid, phospholipid, steroid and oligosaccharide synthesis and modification, calcium ion storage, and detoxification of endogenous and exogenous products. Its volume (and activity) mus…